Preparation method of tissue suitable type composite material dental implant

A dental implant and composite material technology, applied in the field of biomedical composite material preparation, to achieve high biological activity, firm tissue integration, and short implant healing period

Inactive Publication Date: 2014-03-05
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, at present, people mostly focus on the reshaping or modification of the contact part between the implant and the bone tissue, but there are few research reports on the contact part between the implant and the soft tissue such as the gingiva.

Method used

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  • Preparation method of tissue suitable type composite material dental implant
  • Preparation method of tissue suitable type composite material dental implant
  • Preparation method of tissue suitable type composite material dental implant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A method for preparing a tissue-compatible composite dental implant, comprising the following steps:

[0027] (1) Perform micro-arc oxidation treatment on the surface of titanium or titanium alloy implants in contact with bone tissue, and perform micro-arc oxidation in a calcium-phosphorus electrolyte with a mass ratio of calcium and phosphorus of Ca / P=5. Time T=15min, electrode voltage U=450V, electrode frequency f=600Hz, a layer of calcium and phosphorus-containing porous composite ceramic membrane with biological activity is formed;

[0028] (2) The surface part of the implant in contact with the soft tissue was etched in a mixed etching agent composed of hydrofluoric acid and hydrochloric acid. The volume ratio of 47% HF to 38% HCl was 50:50. The etching treatment temperature is 55° C., and the etching treatment time is 5 minutes.

[0029] (3) Immerse the dental implant after micro-arc oxidation and surface etching treatment in a composite simulated body fluid cont...

Embodiment 2

[0034] A method for preparing a tissue-compatible composite dental implant, comprising the following steps:

[0035] (1) Perform micro-arc oxidation treatment on the surface part of the titanium or titanium alloy implant in contact with bone tissue, and perform micro-arc oxidation in a calcium-phosphorus electrolyte with a mass ratio of calcium and phosphorus of Ca / P=3. Time T=10min, electrode voltage U=500V, electrode frequency f=700Hz, a layer of calcium and phosphorus-containing porous composite ceramic membrane with biological activity is formed;

[0036] (2) The surface part of the implant in contact with the soft tissue was etched in a mixed etching agent composed of hydrofluoric acid and hydrochloric acid. The volume ratio of 47% HF to 38% HCl was 50:50. The etching treatment temperature is 55° C., and the etching treatment time is 8 minutes.

[0037] (3) Immerse the dental implant after micro-arc oxidation and surface etching treatment in a composite simulated body fl...

Embodiment 3

[0039] A method for preparing a tissue-compatible composite dental implant, comprising the following steps:

[0040] (1) Perform micro-arc oxidation treatment on the surface part of the titanium or titanium alloy implant in contact with bone tissue, and perform micro-arc oxidation in a calcium-phosphorus electrolyte with a mass ratio of calcium to phosphorus Ca / P=6. Time T=20min, electrode voltage U=400V, electrode frequency f=650Hz, a layer of calcium and phosphorus-containing porous composite ceramic membrane with biological activity is formed;

[0041] (2) The surface part of the implant in contact with the soft tissue was etched in a mixed etching agent composed of hydrofluoric acid and hydrochloric acid. The volume ratio of 47% HF to 38% HCl was 50:50. The etching treatment temperature is 55° C., and the etching treatment time is 10 minutes.

[0042] (3) Immerse the dental implant after micro-arc oxidation and surface etching treatment in a composite simulated body fluid...

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Abstract

The invention relates to a preparation method of a tissue suitable type composite material dental implant. The preparation method comprises the steps of performing micro-arc oxidation treatment on a surface part, in contact with a bone tissue, of a titanium or titanium alloy implant to generate a layer of porous composite ceramic membrane which contains calcium phosphate and has biological activity; performing surface etching treatment on a surface part, in contact with a soft tissue, of the implant in a mixed acid etching agent consisting of hydrofluoric acid and hydrochloric acid; soaking the dental implant subjected to the micro-arc oxidation and surface etching treatment into composite simulated body fluid containing minocycline hydrochloride and bone morphogenetic protein to ensure that an anti-inflammatory drug namely minocycline hydrochloride and the bone morphogenetic protein are simultaneously loaded in surface holes of the implant. The bonding strength between the ceramic membrane on the surface of the implant and a titanium or titanium alloy matrix is improved to 20-30MPa from 10-20Mpa; the bone interface maturation period is shortened to be within 3 months from 3-6 months of the current titanium dental implant; the biological properties of the composite material dental implant accord with relevant regulations of ISO (International Standardization Organization), Chinese Pharmacopoeia and United States Pharmacopoeia.

Description

technical field [0001] The invention relates to a preparation technology of a dental implant, which belongs to the preparation technology of biomedical composite materials. Background technique [0002] Titanium and titanium alloys are currently the implant materials with the longest history and the widest range of applications. Titanium and titanium alloys have good biocompatibility, but have no biological activity, and it is difficult to form a chemical bond with bone directly in the early stage of implantation, and the healing time is longer. In order to improve its biological activity, plasma spraying, ion sputtering, electrophoresis, microwave sintering and other technologies are currently used to prepare hydroxyapatite and bioactive glass coatings on its surface, or to prepare titanium dioxide or sodium titanate by chemical activation treatment. Gel bioactive films, but these coatings or films have obvious interfaces with titanium and titanium alloy substrates, and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/56A61L27/54A61L27/06C25D11/26C23F1/26
Inventor 朱瑞富王志刚王宏元吕宇鹏王晓亭
Owner SHANDONG UNIV
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