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Nano cobaltous oxide-doped minocycline hydrochloride molecular imprinting electrochemical sensor with high sensitivity and preparation method thereof

A technology of minocycline hydrochloride and nano-cobalt oxide, applied in the direction of material electrochemical variables, etc., can solve the problems of low sensitivity, poor cross-linking rigidity, improper matching of functional monomers, template molecules and cross-linking agents, etc.

Inactive Publication Date: 2014-07-16
GUANGXI UNIV FOR NATITIES
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  • Abstract
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Problems solved by technology

The current method is not sensitive due to the inappropriate matching of selected functional monomers with template molecules and cross-linking agents, and the rigidity of cross-linking is also poor.

Method used

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  • Nano cobaltous oxide-doped minocycline hydrochloride molecular imprinting electrochemical sensor with high sensitivity and preparation method thereof

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Embodiment 1

[0014] 1. Treatment of glassy carbon electrodes

[0015] Polish the glassy carbon electrode on a polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder successively, then put it into nitric acid with a volume ratio of 1:1 and sonicate for 6 minutes, then put it into absolute ethanol for 6 minutes, and finally Ultrasonic cleaning with pure water.

[0016] 2. Preparation of molecularly imprinted electrochemical sensor for paracetamol

[0017] To 10.0mL solvent ethanol, add 0.25mmol template molecule minocycline hydrochloride, 2.0mmol20(s)-O-3β-acetyloxy-5-androstene-17β-acylcamptothecin functional unit Body, 3.8mmol cross-linking agent maleic rosin ethylene glycol acrylate, 0.6mmol initiator azobisisobutyronitrile and 0.0180g of nano-cobalt oxide, each adding a chemical reagent ultrasonically dissolved for 5 minutes;

[0018] Take 8 μL of the mixture in step and apply it on the surface of a clean and smooth glassy carbon electrode. After standing for 6 hours, place ...

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Abstract

The invention discloses a nano cobaltous oxide-doped minocycline hydrochloride molecular imprinting electrochemical sensor with high sensitivity and a preparation method of the nano cobaltous oxide-doped minocycline hydrochloride molecular imprinting electrochemical sensor. The minocycline hydrochloride is taken as a template molecule, 20(s)-O-3beta-acetoxyl-5-androstene-17beta-acyl camptothecin is taken as a functional monomer, azodiisobutyronitrile is taken as an initiator, nano cobaltous oxide is taken as a dopant, and maleic rosin ethylene glycol acrylate synthesized from rosin as a raw material is taken as a cross-linking agent, so as to prepare the nano cobaltous oxide-doped minocycline hydrochloride molecular imprinting electrochemical sensor with high sensitivity. The analysis method is simple and practical, and the defects that the traditional analysis method is complicated, expensive in equipment, and low in sensitivity are overcome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a highly sensitive nanometer cobalt oxide-doped minocycline hydrochloride molecularly imprinted electrochemical sensor and a preparation method thereof. Background technique [0002] Minocycline hydrochloride, mainly for the treatment of Staphylococcus, Streptococcus, Pneumococcus, Neisseria gonorrhoeae, Shigella, Escherichia coli, Klebsiella, Proteus, Pseudomonas aeruginosa, Treponema pallidum and Chlamydia disease. However, long-term use of such drugs can cause drug addiction and renal and hepatic insufficiency, and overdose by pregnant women can cause deformities. Therefore, it is listed as a controlled drug by most countries in the world. [0003] Methods for the determination of minocycline hydrochloride include high performance liquid chromatography, chromatography-mass spectrometry, and the like. However, due to the need for expensive instruments and equ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30
Inventor 余会成韦贻春李浩雷福厚谭学才陈其锋
Owner GUANGXI UNIV FOR NATITIES
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