Minocycline hydrochloride nano calcium carbonate preparation and preparation method thereof

A technology of minocycline hydrochloride and nano-calcium carbonate, applied in the field of medicine, can solve the problems of slow excretion, potential safety hazards, side effects of nano-cycline hydrochloride, etc., and achieves the effects of high drug loading rate, improved stability, and reduced toxic and side effects

Active Publication Date: 2012-07-04
天津渤化讯创科技有限公司
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, nanocycline hydrochloride has brought great side effects during its use, and its excretion in urine is much lower than that of other tetracyclines, and the excretion is slow, most of which are excreted by the kidneys and bile
Therefore, patients with liver and kidney insufficiency, esophageal passage barriers, the elderly, patients with oral malabsorption or inability to eat, and patients with deteriorating general conditions (because of vitamin K deficiency) may have potential safety hazards during use.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Minocycline hydrochloride nano calcium carbonate preparation and preparation method thereof
  • Minocycline hydrochloride nano calcium carbonate preparation and preparation method thereof
  • Minocycline hydrochloride nano calcium carbonate preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1) Prepare calcium chloride and ammonium carbonate aqueous solutions of 10 millimoles per liter respectively for subsequent use.

[0025] 2) Take 0.1 ml of calcium chloride and add the corresponding epiminocycline hydrochloride (the molar ratio of calcium chloride to epiminocycline hydrochloride is 5:1), after ultrasonic dispersion is uniform, the calcium chloride aqueous solution containing the drug Add it to 10 ml of organic phase, and ultrasonically homogenize to form A emulsion, which is set aside.

[0026] 3) Take the same volume of ammonium carbonate aqueous solution as the calcium chloride aqueous solution containing the drug in step 2, add it to 5 ml of organic phase, and ultrasonically homogenize to form B emulsion for later use.

[0027] 4) Under the condition of magnetic stirring, slowly add emulsion B into emulsion A, and stir for 2 hours after adding.

[0028] 5) Add the mixed solution in step 4 to ethanol to break the emulsion, then centrifuge and wash, a...

Embodiment 2

[0031] 1) Prepare calcium chloride and ammonium carbonate aqueous solutions of 100 millimoles per liter respectively for subsequent use.

[0032] 2) Take 0.2 ml of calcium chloride and add the corresponding epiminocycline hydrochloride (the molar ratio of calcium chloride to epiminocycline hydrochloride is 4:1), after ultrasonic dispersion is uniform, the calcium chloride aqueous solution containing the drug Add it to 15 ml of organic phase, and ultrasonically homogenize to form A emulsion, which is set aside.

[0033] 3) Take the same volume of ammonium carbonate aqueous solution as the calcium chloride aqueous solution containing the drug in step 2, add it to 15 ml of organic phase, and ultrasonically homogenize to form B emulsion, which is set aside.

[0034] 4) Under the condition of magnetic stirring, slowly add emulsion B into emulsion A, and stir for 1.5 hours after adding.

[0035] 5) Add the mixed solution in step 4 to ethanol to break the emulsion, then centrifuge a...

Embodiment 3

[0037] 1) Prepare 300 millimoles per liter of calcium chloride and ammonium carbonate aqueous solution respectively for subsequent use.

[0038] 2) Take 0.3 ml of calcium chloride and add the corresponding epiminocycline hydrochloride (the molar ratio of calcium chloride to epiminocycline hydrochloride is 3:1), after ultrasonic dispersion is uniform, the calcium chloride aqueous solution containing the drug Add it to 20 ml of organic phase, and ultrasonically homogenize to form A emulsion, which is set aside.

[0039] 3) Take the ammonium carbonate aqueous solution of the same volume as the calcium chloride aqueous solution containing the drug in step 2, add it to 20 ml of organic phase, and ultrasonically homogenize to form B emulsion for later use.

[0040] 4) Under the condition of magnetic stirring, slowly add B emulsion into A emulsion, and stir for 1 hour after adding.

[0041] 5) Add the mixed solution in step 4 to ethanol to break the emulsion, then centrifuge and was...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a minocycline hydrochloride nano calcium carbonate preparation and a preparation method thereof. The preparation method comprises the following steps: adding minocycline hydrochloride into calcium chloride aqueous solution, wherein the molar ratio of the calcium chloride to the minocycline hydrochloride is 5:1-1:1; after mixture is uniform by ultrasonic dispersion, addingthe calcium chloride aqueous solution containing medicine into an organic phase, wherein the volume ratio of the calcium chloride aqueous solution to the organic phase is 1:50-1:200; carrying out ultrasonic uniformity to form emulsion A; adding ammonium carbonate aqueous solution which has the same volume with the calcium chloride aqueous solution containing medicine in step 2 into the organic phase, and carrying out ultrasonic uniformity to form emulsion B; under the magneton stirring condition, slowly adding the emulsion B into the emulsion A; after adding, stirring for 0.5-2h; adding mixedsolution into ethanol for demulsification; then, carrying out centrifugal washing; and finally, naturally drying a sample. The preparation method has the advantages of simple and quick preparation process, short preparation period and high yield. The particle diameter of the prepared minocycline hydrochloride nano calcium carbonate is controllable within 40-150 nanometers and is even, and the medicine carrying ratio is 20-40%.

Description

technical field [0001] The invention relates to a minocycline hydrochloride nano-calcium carbonate preparation and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Minocycline hydrochloride is also known as minocycline hydrochloride; minocycline. The English name is minocycline hydrochloride hydrate. Common minocycline hydrochloride capsules are yellow crystalline powder, suitable for staphylococcus, streptococcus, pneumococcus, Neisseria gonorrhoeae, Shigella, Escherichia coli, Klebsiella, Proteus, Pseudomonas aeruginosa Infections caused by pathogens sensitive to minocycline hydrochloride such as Bacillus, Treponema pallidum and Chlamydia. For example: 1. Septicemia, bacteremia. 2. Superficial suppurative infection 3. Deep suppurative disease 4. Acute and chronic bronchitis, asthmatic bronchitis and other diseases and infections. If these diseases are not treated in time and treated, they will cause great harm to...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/65A61K47/04A61K33/10A61P31/04A61P3/14
CPCY02A50/30
Inventor 常津王小敏王汉杰王生
Owner 天津渤化讯创科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap