Minocycline hydrochloride nano calcium carbonate preparation and preparation method thereof

Abstract

The invention relates to a minocycline hydrochloride nano calcium carbonate preparation and a preparation method thereof. The preparation method comprises the following steps: adding minocycline hydrochloride into calcium chloride aqueous solution, wherein the molar ratio of the calcium chloride to the minocycline hydrochloride is 5:1-1:1; after mixture is uniform by ultrasonic dispersion, addingthe calcium chloride aqueous solution containing medicine into an organic phase, wherein the volume ratio of the calcium chloride aqueous solution to the organic phase is 1:50-1:200; carrying out ultrasonic uniformity to form emulsion A; adding ammonium carbonate aqueous solution which has the same volume with the calcium chloride aqueous solution containing medicine in step 2 into the organic phase, and carrying out ultrasonic uniformity to form emulsion B; under the magneton stirring condition, slowly adding the emulsion B into the emulsion A; after adding, stirring for 0.5-2h; adding mixedsolution into ethanol for demulsification; then, carrying out centrifugal washing; and finally, naturally drying a sample. The preparation method has the advantages of simple and quick preparation process, short preparation period and high yield. The particle diameter of the prepared minocycline hydrochloride nano calcium carbonate is controllable within 40-150 nanometers and is even, and the medicine carrying ratio is 20-40%.

Description

technical field [0001] The invention relates to a minocycline hydrochloride nano-calcium carbonate preparation and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Minocycline hydrochloride is also known as minocycline hydrochloride; minocycline. The English name is minocycline hydrochloride hydrate. Common minocycline hydrochloride capsules are yellow crystalline powder, suitable for staphylococcus, streptococcus, pneumococcus, Neisseria gonorrhoeae, Shigella, Escherichia coli, Klebsiella, Proteus, Pseudomonas aeruginosa Infections caused by pathogens sensitive to minocycline hydrochloride such as Bacillus, Treponema pallidum and Chlamydia. For example: 1. Septicemia, bacteremia. 2. Superficial suppurative infection 3. Deep suppurative disease 4. Acute and chronic bronchitis, asthmatic bronchitis and other diseases and infections. If these diseases are not treated in time and treated, they will cause great harm to...

AI Technical Summary

Problems solved by technology

[0004] However, nanocycline hydrochloride has brought great side effects during its use, and its excretion in urine is much lower than that of other tetracyclines, and the excretion is slow, most of which are excreted by the kidneys and bile

Therefore, patients with liver and kidney insufficiency, esophageal passage barriers, the elderly, patients with oral malabsorption or inability to eat, and patients with deteriorating general conditions (because of vitamin K deficiency) may have potential safety hazards during use.

Images