Application of minocycline hydrochloride to preparation of medicine for treating autoimmune uveitis and treatment method of autoimmune uveitis
A minocycline hydrochloride, autoimmune technology, used in drug combinations, active ingredients of tetracycline, allergic diseases, etc. The effect of reducing immune cell infiltration
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Embodiment 1
[0025] Treatment effect of minocycline hydrochloride (MINO) treatment group on autoimmune uveitis (EAU)
[0026] Lewis rats (180-200g) were randomly divided into three groups after injection of 0.1mL IRBP / Freund's adjuvant into the rear foot pad: (1) EAU group; (2) 25 mg / kg MINO group; (3) 50 mg / kg MINO group. Normal Lewis rats served as the control group (Control). On the day of immunization (d0), MINO solution (25 mg / kg and 50 mg / kg) was intraperitoneally injected daily for 14 consecutive days (d14). On the second day after immunization (d2), the inflammatory response of the anterior chamber was observed and scored with a slit lamp. On the 14th day, the rats were sacrificed, the eyeball tissues were taken, and histopathological sections were made to observe the microstructural changes of the retina and score (see attached figure 1 shown).
Embodiment 2
[0028] Minocycline hydrochloride (MINO) treatment group inhibited microglial activation
[0029] On the 14th day, the rats were sacrificed to take eyeball tissues, frozen sections, immunofluorescence staining for IBA-1 and CD68, and observing the activation of microglial cells (see attached figure 2 shown).
Embodiment 3
[0031] Minocycline hydrochloride (MINO) treatment group inhibited the secretion of inflammatory factors in microglial cells
[0032] On the 14th day, the rats were sacrificed to take eyeball tissues, frozen sections, immunofluorescent staining of IBA-1 and IL-1β, and the activation of microglial cells were observed (see appendix image 3 shown).
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