Memantine hydrochloride slow-release pill and preparation method thereof

A technology of memantine hydrochloride and sustained-release pills, which is applied in sugar-coated pills, pharmaceutical formulas, and devices that make drugs into special physical or ingestible forms, and can solve problems such as being easily affected by humid environments Burst release, improved stability, guaranteed curative effect

Active Publication Date: 2014-09-03
ZHEJIANG JINGXIN PHARMA
View PDF10 Cites 20 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this patent solves the risk of sudden release of sustained-release tablets, the capsule is easily affected by the humid environment during long-term storage. Since memantine hydrochloride is a very water-soluble substance, there is a drug-containing layer to slow-release The risk of layer migration, and thus the risk of sudden release
[0005] Patent CN103417491 protects the preparation of memantine hydrochloride sustained-release pellets, mainly protecting the process of the blank pellet core and the memantine hydrochloride drug sustained-release composite layer wrapped in the outer layer, but this process has the same risk of burst release as patent CN103181914

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Memantine hydrochloride slow-release pill and preparation method thereof
  • Memantine hydrochloride slow-release pill and preparation method thereof
  • Memantine hydrochloride slow-release pill and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: In order to study the impact of the isolation layer on the dissolution of the sustained-release capsule under high humidity conditions, two kinds of pellets were prepared, namely, drug-containing pellet A without isolation layer (or isolation coating layer) and drug-containing pellet B with isolation layer , and then poured into the capsules to form corresponding slow-release capsules A and slow-release capsules B, and put them into a closed container with a relative humidity of 92.5% to investigate the dissolution results in 5 and 10 days.

[0042] One, the preparation of sustained-release capsule A

[0043] (1) Preparation of drug-containing pellets of memantine hydrochloride:

[0044]

[0045] 1.1 Weigh hypromellose E3 into a container filled with purified water at 80°C to 90°C, stir to disperse, then add cold purified water, and stir while adding, to obtain I;

[0046] 1.2 Put polyethylene glycol 6000 and memantine hydrochloride in a container, add...

Embodiment 2

[0083] Embodiment 2: the preparation method of memantine hydrochloride sustained-release capsules:

[0084] (1): Preparation of main drug layer pellets containing memantine hydrochloride (i.e. drug-containing pellets):

[0085]

[0086] 1.1 Weigh hydroxypropyl cellulose and add it to a container filled with purified water at 80°C to 90°C, stir to disperse, then add cold purified water, and stir while adding to obtain I.

[0087] 1.2 Put polyethylene glycol and memantine hydrochloride in a container, add purified water to dissolve, and obtain II.

[0088] 1.3 Then add (I) into (II), stir evenly, then add talcum powder while stirring, stir to disperse the talc powder evenly, pass through an 80-mesh sieve, keep stirring gently with the agitator, and obtain the drug-containing coating solution for later use.

[0089] 1.4 Put the blank pellet core into the material cylinder of the fluidized bed by manual feeding, start heating, and when the temperature of the material is kept a...

Embodiment 3

[0104] Embodiment 3: the preparation method of memantine hydrochloride sustained-release capsules

[0105] (1) Preparation of main drug layer pellets:

[0106]

[0107] 1.1 Weigh hydroxypropyl cellulose and add it to a container filled with purified water at 80°C to 90°C, stir to disperse, then add cold purified water, and stir while adding to obtain I.

[0108] 1.2 Put polyethylene glycol and memantine hydrochloride in a container, add purified water to dissolve, and obtain II.

[0109] 1.3 Then add (I) into (II), stir evenly, then add talcum powder while stirring, and stir to disperse the talcum powder evenly. Pass through an 80-mesh sieve and keep stirring gently with the agitator to obtain a drug-containing coating solution for later use.

[0110] 1.4 Put the blank pellet core into the material cylinder of the fluidized bed by manual feeding, start heating, and when the temperature of the material is kept above 35°C, turn on the atomization pressure (1.6BAR), adjust t...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a memantine hydrochloride slow-release pill and a preparation method thereof. Packing inside a capsule is a memantine hydrochloride slow-release pill; the memantine hydrochloride slow-release pill sequentially comprises a hollow pill core, a main medicine layer containing memantine hydrochloride, an isolated coating layer and a slow-release coating layer from inside to outside. The memantine hydrochloride slow-release pill is good in stability and free of an initial burst release phenomenon, the condition that the medicine is lastingly, evenly and slowly released is ensured, and the curative effect of the product is improved.

Description

technical field [0001] The invention relates to a memantine hydrochloride slow-release pill and a preparation method thereof, belonging to the technical field of pharmacy. Background technique [0002] With the aging of the world population and the improvement of people's living standards, the average life expectancy is also extended. In 2002, the elderly over the age of 60 accounted for 20% of the world's total population. By 2050, the number of elderly people It is expected to reach 21% of the world's total population. With the aging of the world's population, senile dementia has become the primary problem of human health, and the incidence rate is increasing year by year with the progress of population aging. At present, the number of sick people in the world has exceeded 18 million, and the number of sick people in my country is about 6 million, which is the country with the largest number of sick people in the world. Memantine HCl is used in the treatment of moderate ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K9/22A61K31/13A61J3/06A61P25/28
Inventor 潘裕生胡叶青张利锋俞悦喻颖利徐子金
Owner ZHEJIANG JINGXIN PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap