51 results about "Shuang-huang-lian" patented technology

The invention provides a method for preparing an injection, comprising that extracting respectively the scutellaria root, honeysuckle flower and capsule of weeping forsythia, then preparing the injection. The invention also provides a component check method of the injection, for improving the quality control level, assure the treatment effect, and support the product detection.

The invention relates to a microsphere used for injecting Shuanghuanglian which is used for treating poultry viral diseases and a preparation method thereof; the microsphere consists of 2-60% of Chinese medicinal material extracts which are taken as active ingredients and 39-95% of biodegradable medicinal high-molecular excipients which have microsphere weight and have molecular weight ranging from 4,000 to 9,000,000 by weight proportion; wherein, the weight percentage of medicinal materials is as follows: 13-40% of Chinese goldthread, 15-45% of honeysuckle, 25-61% of forsythia and 11-40% of milk veteh. The medicines are prepared into microspheres by emulsifying dispersion method. The beneficial effects of the invention is that: (1) developing a new medicine preparation for preventing and treating poultry viral diseases and increasing disease resistance of the body; (2) reasonable prescription and strong antiviral ability; (3) advanced technique, stable preparation and long storage time; (4) broad medicine sources and no toxicity and side effect, little drug resistance generated and meeting the international sanitary inspection requirements. Especially, the microsphere has significant effect on the treatment of poultry infectious bursal disease, untypical Newcastle disease, infective bronchitis, etc.

The invention relates to a Shuanghuanglian soluble powder preparation technique. The Shuanghuanglian soluble powder is prepared by the following medicines with parts by weight: 800 to 1000 parts of honeysuckle, 800 to 1000 parts of radices scutellariae and 1600 to 2000 parts of fructus forsythiae; the preparation technique is characterized by comprising the steps of decocting the honeysuckle with water for two times (one hour for the first time and 45 minutes for the second time), collecting decoction, decocting the radices scutellariae with water for three times, collecting decoction, filtering, concentrating filter liquid, drying under reduced pressure, standby, grinding the fructus forsythiae, adding water and decocting for three times, depositing, filtering, and spray drying concentrated liquid which is then ground into fine powder with the extraction of the honeysuckle and the fructus forsythiae, adding proper grape sugar and obtaining the Shuanghuanglian soluble powder. The Shuanghuanglian soluble powder is characterized by high active component content, slight toxicity and side effect, no drug residues, capability of being used in the mixed feeding and drinking of large-scale culture, convenient storage and transportation, and meets the requirements of new veterinary drug preparations. The Shuanghuanglian soluble powder is applicable to curing livestock infectious diseases with determined curative effect.

An eye drops "Shuanghuanglian" contains the aseptic powder of honeysuckle powder, coptis root and forsythia fruit and the solvent which is an isotonic solution of sodium chloride and hydroxyphenyl ethylester. Its advantages are high curative effect to virus infection of eye, and high safety.

The invention discloses a Shuanghuanglian dispersible tablet prepared from honeysuckle flower, capsule of weeping forsythia, baikal skullcap root glycosides and medicinal auxiliary materials including crumbling agent, bulking agent and lubricating agent. The invention also discloses the process for preparing the tablet through pelletization with fluidized bed.

The invention relates to a nano Shuanghuanglian injection used for poultry and a preparation method thereof; the nano Shuanghuanglian injection consists of 3-55% of Chinese medicinal material extracts which are taken as active ingredients and 41-90% of biodegradable medicinal high-molecular excipients which have microsphere weight and have molecular weight ranging from 4,000 to 9,000,000 by weight proportion; wherein, the weight percentage of medicinal materials is as follows: 10-42% of Chinese goldthread, 10-50% of honeysuckle, 10-40 % of forsythia and 10-38% of radix scutellariae. The medicines are prepared into microspheres by spray drying process. The invention has the benefical effects of (1) developing a new medicine for preventing and treating poultry viral diseases for clinical application; (2) reasonable prescription and strong antiviral ability; (3) advanced technique, stable preparation and long storage time; (4) broad medicine sources and no toxicity and side effect. Especially, the nano Shuanghuanglian injection has significant effect on the treatment of poultry infectious bursal disease, untypical Newcastle disease, infective bronchitis, etc.

The invention discloses a concentrated Shuanghuanglian oral liquid preparation. A formula of the concentrated Shuanghuanglian oral liquid comprises, in parts by mass: 350-400 parts of honeysuckle flowers, 350-400 parts of radix scutellariae, 700-800 parts of fructus forsythiae, 300-400 parts of sucrose and 100-180 parts of essence.

The invention relates to a traditional Chinese veterinary medicine compound preparation Shuanghuanglian for injection as well as a preparation technology and an application thereof. The compound preparation comprises the components in parts by weight as follows: 1300-1700 parts of honeysuckle, 1300-3700 parts of radix scutellariae and 2500-7500 parts of fructus forsythiae. Slow-release accessories comprise 150 parts of hydroxymethyl propyl cellulose and 100 parts of sodium carboxymethyl cellulose. The compound preparation contains the slow-release accessories, so that the injection time of large animals can be reduced, and the stress response of the large animals can be reduced. The traditional Chinese veterinary medicine compound preparation for injection has antiviral, antibacterial, anti-inflammatory, antipyretic, analgesic, immunity-improving effects and the like. Veterinarian clinic proves that the compound preparation can be used for treating epidemic diarrhea; transmissible gastroenteritis; necrotic enteritis; septicemia caused by various epidemic diseases; cough, dyspnea, skin cyanosis, arthrocele which are caused by chromic respiratory diseases such as streptococcosis, haemophflussuis, contagious porcine pleuropneumonia, swine plague and the like; and porcine reproductive and respiratory syndrome and cow mastitis.

The invention discloses a veterinary Shuanghuanglian oral liquid preparation processed by using probiotics. Secondary strains of functional microbes are inoculated to fermentation liquid of a Shuanghuanglian formula, and deep high-density fermentation of liquid is performed at normal temperature under normal pressure by using the life action of the functional microbes to sufficiently and effectively dissolve and convert active ingredients in the Shuanghuanglian formula, thus obtaining the Shuanghuanglian oral liquid biological preparation. The invention also provides a preparation method of the veterinary Shuanghuanglian oral liquid preparation at the same time. The Shuanghuanglian formula is screened as a Chinese medicinal formula, and the antibacterial, antivirus and heat clearing active ingredients included in the Shuanghuanglian formula are furthest extracted by using the functional microbes including lactobacillus acidophilus and candida utilis, so that the curative effect is enhanced. Meanwhile, the lactobacillus acidophilus and the candida utilis can play a role in maintaining and regulating the balance of gastrointestinal microbiota of animals.

The invention relates to a compound Shuanghuanglian granular preparation for a pet and a preparation method of the preparation. The compound Shuanghuanglian granular preparation for the pet is prepared from traditional Chinese medicine composition including flos lonicerae, radix scutellariae, fructus forsythia, radix aucklandiae, fructus aurantii, cortex magnoliae officinalis, radix et rhizoma rhei and the like as well as a pet palatable corrective and an auxiliary, has the efficacy of clearing away heat and toxic materials, eliminating dampness with aromatics, invigorating stomach and relieving stasis and particularly has a good clinical control effect on feline distemper.

The invention discloses a method for refining a Shuanghuanglian preparation by using a membrane separation technology. The method comprises the following steps: A. preparing water extract: weighing honeysuckle flower, radix scutellariae and fructus forsythiae according to a prescription, and carrying out water extraction on the weighed materials for later use; B. refining by a ceramic membrane: adding the water extract into a ceramic membrane device for continuously filtering, and collecting filtrate, wherein the pore sizes of a filtration membrane of the ceramic membrane device are 400-500nm;C. directly using the filtrate obtained in the step B as liquid medicine to leave factory, or taking the filtrate as a raw material to prepare extract, tablet, powder, granules, injection and suppository. The treatment method provided by the invention enables the efficacy of the original Shuanghuanglian water extract to be effectively improved; in particular, the 450nm film determined by means ofseries of research and development has the best comparative advantages and practical effects in terms of parameters such as extract yield, chlorogenic acid content, baicalin content, forsythin content, membrane flux and interception performance.

The invention relates to application of a Shuanghuanglian preparation in virus infection resistance. Specifically, the invention provides an application of a chlorogenic acid compound or a pharmaceutically acceptable salt or an extract of the chlorogenic acid compound. Experiments show that the Shuanghuanglian preparation (oral liquid) and the active ingredient chlorogenic acid thereof have obvious antiviral effects on severe acute respiratory syndrome coronavirus (SARS-CoV), influenza virus (influenza virus), Middle East Respiratory Syndrome (MERS) and 2019-nCoV (new coronavirus), and prove that the Chinese patent medicine Shuanghuanglian preparation (oral liquid) can be used for treating virus infectious diseases.

The invention relates to the field of veterinary medicines, and discloses a veterinary Shuanghuanglian preparation and a preparation method for the same. The raw material medicine of the veterinary Shuanghuanglian preparation disclosed by the invention is composed of the components in parts by weight: 1 part by weight of honeysuckle, 1 part by weight of scutellaria baicalensis, 2 parts by weight of fructus forsythiae, and 2 parts by weight of astragalus mongholicus. According to the invention, astragalus mongholicus is added based on the traditional Shuanghuanglian prescription, so that the veterinary Shuanghuanglian preparation prepared in this way is higher in pharmaceutical effect. Simultaneously, the preparation method for the veterinary Shuanghuanglian preparation adopts a method combining microwave with extrusion, thus the extraction rate of the active ingredients of each constituent is remarkably increased.

The invention discloses a chicken feed for improving disease resistance and survival rate, a preparation method and a feeding method thereof. The chicken feed comprises the following raw materials: corn, soybean meal, rice bran, peanut bran, bone meal, calcium, phosphorus, magnesium and Chinese herbal medicines. The Chinese herbal medicines comprise lucid ganoderma, red dates, astragalus membranaceus, lonicera japonica, lophatherum gracile, radix isatidis, codonopsis pilosula, hedyotis hedyotidea, sculellaria barbata, alpinia japonica, medlar, gardenia jasminoides ellis, mussaenda pubescens, senecio scandens, momordica grosvenori, folium isatidis, orange peel, Shuanghuanglian, radix bupleuri, sweet wormwood, platycodon grandiflorum, liquorice and plantain herb; the raw materials are smashed into powder, and the feed is prepared through stirring, mixing and sealed fermentation; and the prepared feed is fed twice in the morning and evening. The chicken feed can effectively improve the disease resistance and survival rate of the hang chickens, enhance the immunity of chicken bodies, improve the taste of meat, and is free of toxic and harmful substance residues, environment-friendly and healthy.

The invention discloses a Shuanghuanglian pill and process of preparation, wherein the pill includes the aqueous extracts and plasticizers of the following raw materials (by weight portions): weeping forsythia 2 parts, root of large-flowered skullcap 1 part, honeysuckle flower 1 part, and plasticizer 0.13-1.1 part.

The invention discloses a method for detecting quality of Shuanghuanglian of veterinary Shuanghuanglian oral liquid based on a spectrum-activity relationship. The method comprises the following steps: (1) establishing an HPLC fingerprint spectrum of the veterinary Shuanghuanglian oral liquid; (2) extracting characteristic chromatographic peaks; (3) determining the anti-inflammatory effect of the veterinary Shuanghuanglian oral liquid; and (4) establishing spectrum-activity correlation analysis by adopting a grey correlation analysis method so as to evaluate the anti-inflammatory activity of the characteristic peak. The method has the advantages of simplicity, high objectivity and the like, and is beneficial to quality control of the veterinary Shuanghuanglian oral liquid.

The invention belongs to the technical field of medicine preparation, and particularly relates to a method for preparing veterinary Shuanghuanglian oral liquid, which comprises the following steps: mixing a honeysuckle extracting solution, a fructus forsythiae extracting solution and a radix scutellariae extracting solution according to a weight ratio of 1: 1.5: 1, and then feeding into a preparation device for processing and producing. The preparation device comprises a mixing cylinder, wherein an inner cylinder is arranged inside the mixing cylinder, a base is arranged below the mixing cylinder, the outer wall of the mixing cylinder is fixedly connected with an externally-attached sleeve, the outer wall of the externally-attached sleeve is fixedly connected with three equidistant wheel rings, the inner wall of the base is provided with three equidistant sliding grooves, and the three wheel rings on the externally-attached sleeve are movably connected with the three sliding grooves in the base respectively. According to the present invention, the added raw material liquid is rotationally mixed by using the rotating mixing cylinder, such that the overall mixing effect of the raw material liquid is improved, and the problems of insufficient mixing and pungent smell emission caused by stirring and mixing of the raw material liquid in the existing pharmaceutical process are solved.

The invention provides a composition for treating hepatitis B and a preparation method of the composition. The composition comprises the following components: Ebselen, organic germanium Ge-132, lamivudine, Chinese magnoliavine fruits, isatis roots, forsythia suspensa, rhubarb, wild chrysanthemum flowers and Shuang huang lian, wherein the weight part ratio of the ebselen to the organic germanium Ge-132 to the lamivudine to the Chinese magnoliavine fruits to the isatis roots to the forsythia suspensa to the rhubarb to the wild chrysanthemum flowers to the Shuang huang lian is 1: (4-8): 2: 0.5: 0.5: 0.5: 0.5: 0.5: 0.5. A preparation device for preparing the composition comprises a reaction kettle, a stirring machine, a concentrating machine, a vacuum drying machine and a tabletting machine. According to the composition provided by the invention, based on treatment of the Lamivudine, the Ebselen, the organic germanium Ge-132, the Chinese magnoliavine fruits, the isatis roots, the forsythiasuspensa, the rhubarb, the wild chrysanthemum flowers and the Shuang huang lian are used, the composition has an obvious effect on resisting hepatitis B viruses, has a great breakthrough in specificcurative effects such as treatment effect and rebound prevention, and has the advantages of quick and good comprehensive curative effect and smaller rebound proportion.

The invention provides a traditional Chinese medicine composition which is prepared from the following components in parts by weight: 40-50 parts of wormwood, 10-15 parts of raw liquorice, 1-4 parts of fructus forsythiae, 2-4 parts of Shuanghuanglian, 1-2 parts of medicated leaven, 1-2 parts of poria cocos, 15-28 parts of wormwood root, 1-2 parts of raw bighead atractylodes rhizome, 0.8-1 part ofdivaricate saposhnikovia root, 5-8 parts of honeysuckle, 0.5-1 part of pogostemon cablin, 1-2 parts of gynostemma pentaphylla, 0.5-1 part of catharanthus roseus, 2-4 parts of aloe, 0.2-0.3 part of ginseng, 0.8-1 part of safflower, 0.8-1 part of caulis spatholobi, 0.2-0.4 part of cordyceps sinensis and 5-8 parts of oyster powder. The invention also provides a poultry feed which comprises the traditional Chinese medicine composition and a grain coarse grain feed, and the grain coarse grain feed comprises the following raw material components in parts by weight: 30-40 parts of corn flour, 30-40 parts of soybean flour, 20-25 parts of sweet potato powder, 2-5 parts of edible salt and 20-25 parts of soybean oil. The poultry feed can be prepared by adopting a crushing method or a decocting method, and the nutritional ingredients and the efficacy value of the feed are reserved.