53 results about "Shuang-huang-lian" patented technology

The invention provides a method for preparing an injection, comprising that extracting respectively the scutellaria root, honeysuckle flower and capsule of weeping forsythia, then preparing the injection. The invention also provides a component check method of the injection, for improving the quality control level, assure the treatment effect, and support the product detection.

Disclosed is a pharmaceutical composition for treating and preventing respiratory tract viral infection, which is prepared from wild chrysanthemum flower 1-5 parts, bupleurum root 1-10 parts, capsule of weeping forsythia 1-10 parts, baikal skullcap root 5-10 parts, honeysuckle flower 5-10 parts and bitter apricot kernel 4-8 parts.

The invention belongs to the field of traditional Chinese medicine preparation, relating to a Shuanghuanglian in situ gel preparation and a preparation method thereof. The in situ gel preparation is prepared from water as solvent, Shuanghuanglian extract, in situ gel matrix accepted in the field and other necessary auxiliary materials in pharmacy and clarifies the preparation method. The invention is freely flowing liquid at room temperature, forms semi-solid gel after applying drug to rectum of patients and has the advantages of exact effect, stable performance, simple preparation, convenient drug administration, strong patient compliance, no toxic and side effect, no adverse reaction, high bioavailability and the like. The Shuanghuanglian in situ gel preparation has the efficacy of relieving the exterior syndrome with drugs pungent in flavor and cool in property, clearing away heat and toxic material and dispersing lung qi and wind heat and is used for treating fever caused by exogenous wind heat, cough, pharyngalgia, virus and bacterial infection upper respiratory tract infection, pulmonitis, tonsillitis, pharyngitis and the like.

The invention belongs to the technical field of veterinary medicines, particularly relates to an application of Shuanghuanglian oral liquor in preparation of a medicine for treating and preventing poultry virosis, and in particular relates to an application of Shuanghuanglian oral liquor in preparation of a medicine for treating and preventing newcastle disease or infectious bronchitis. As the experiments show, the Shuanghuanglian oral liquor has an excellent effect on immunological enhancement respect to newcastle disease and infectious bronchitis bivalent inactivated vaccines (LaSota-M41 strains), can be used for obviously improving the antibody level as well as the immune protective effects of the newcastle disease and infectious bronchitis bivalent inactivated vaccines (LaSota-M41 strains), and also can be used for improving the infectious bronchitis virus serum antibody titer, and as a result, the anti-excitability ability of the poultry organisms is improved.

The present invention relates to Chinese medicine Shuanghuanglian ointment and its quality control method. The preparation process of Chinese medicine Shuanghuanglian ointment includes the following steps: decocting, filtering and alcohol extracting skullcap root, honeysuckle and forsythia separately to obtain water solution; mixing the water solution, regulating pH to 5.0-9.0, decompression concentrating, low temperature drying and crushing to obtain medicine powder; dissolving polyethylene glycol-400, polyethylene glycol-6000 and ethyl hydroxyl benzoate in water bath at 40-80 deg.c, adding the medicine powder gradually while stirring and lowering the temperature to room temperature to form ointment; and packing in tube. The Chinese medicine Shuanghuanglian ointment has determined curative effect.

The invention relates to a microsphere used for injecting Shuanghuanglian which is used for treating poultry viral diseases and a preparation method thereof; the microsphere consists of 2-60% of Chinese medicinal material extracts which are taken as active ingredients and 39-95% of biodegradable medicinal high-molecular excipients which have microsphere weight and have molecular weight ranging from 4,000 to 9,000,000 by weight proportion; wherein, the weight percentage of medicinal materials is as follows: 13-40% of Chinese goldthread, 15-45% of honeysuckle, 25-61% of forsythia and 11-40% of milk veteh. The medicines are prepared into microspheres by emulsifying dispersion method. The beneficial effects of the invention is that: (1) developing a new medicine preparation for preventing and treating poultry viral diseases and increasing disease resistance of the body; (2) reasonable prescription and strong antiviral ability; (3) advanced technique, stable preparation and long storage time; (4) broad medicine sources and no toxicity and side effect, little drug resistance generated and meeting the international sanitary inspection requirements. Especially, the microsphere has significant effect on the treatment of poultry infectious bursal disease, untypical Newcastle disease, infective bronchitis, etc.

The invention relates to a Shuanghuanglian soluble powder preparation technique. The Shuanghuanglian soluble powder is prepared by the following medicines with parts by weight: 800 to 1000 parts of honeysuckle, 800 to 1000 parts of radices scutellariae and 1600 to 2000 parts of fructus forsythiae; the preparation technique is characterized by comprising the steps of decocting the honeysuckle with water for two times (one hour for the first time and 45 minutes for the second time), collecting decoction, decocting the radices scutellariae with water for three times, collecting decoction, filtering, concentrating filter liquid, drying under reduced pressure, standby, grinding the fructus forsythiae, adding water and decocting for three times, depositing, filtering, and spray drying concentrated liquid which is then ground into fine powder with the extraction of the honeysuckle and the fructus forsythiae, adding proper grape sugar and obtaining the Shuanghuanglian soluble powder. The Shuanghuanglian soluble powder is characterized by high active component content, slight toxicity and side effect, no drug residues, capability of being used in the mixed feeding and drinking of large-scale culture, convenient storage and transportation, and meets the requirements of new veterinary drug preparations. The Shuanghuanglian soluble powder is applicable to curing livestock infectious diseases with determined curative effect.

An eye drops "Shuanghuanglian" contains the aseptic powder of honeysuckle powder, coptis root and forsythia fruit and the solvent which is an isotonic solution of sodium chloride and hydroxyphenyl ethylester. Its advantages are high curative effect to virus infection of eye, and high safety.

The invention discloses a Shuanghuanglian dispersible tablet prepared from honeysuckle flower, capsule of weeping forsythia, baikal skullcap root glycosides and medicinal auxiliary materials including crumbling agent, bulking agent and lubricating agent. The invention also discloses the process for preparing the tablet through pelletization with fluidized bed.

The invention relates to a nano Shuanghuanglian injection used for poultry and a preparation method thereof; the nano Shuanghuanglian injection consists of 3-55% of Chinese medicinal material extracts which are taken as active ingredients and 41-90% of biodegradable medicinal high-molecular excipients which have microsphere weight and have molecular weight ranging from 4,000 to 9,000,000 by weight proportion; wherein, the weight percentage of medicinal materials is as follows: 10-42% of Chinese goldthread, 10-50% of honeysuckle, 10-40 % of forsythia and 10-38% of radix scutellariae. The medicines are prepared into microspheres by spray drying process. The invention has the benefical effects of (1) developing a new medicine for preventing and treating poultry viral diseases for clinical application; (2) reasonable prescription and strong antiviral ability; (3) advanced technique, stable preparation and long storage time; (4) broad medicine sources and no toxicity and side effect. Especially, the nano Shuanghuanglian injection has significant effect on the treatment of poultry infectious bursal disease, untypical Newcastle disease, infective bronchitis, etc.

The invention discloses a medicine for treating lung cancer, breast cancer and lymph cancer and a preparation method thereof. The medicine is composed of traditional Chinese medicines and western medicines, and components of the medicine mainly contain drugs such as fibrous ginseng root, astragalus membranaceus, Juncaceae, ginseng, bighead atractylodes rhizome, gynostemma pentaphyllum, dried tangerine peel, radix codonopsis, poria, Rhizoma Pinelliae, costusroot, Amomum villosum, rhubarb, boat-fruited sterculia seed, Semiaquilegia, Radix Actinidiae chinensis, solanum nigrum, solanum lyratum, Glabrous sarcandra Glabrous Herb, crotalaria sessiliflora, trichosanthes kirilowii Maxim, musk, bezoar, toad, borneol, centipede, rhizoma picrorhizae, a pulse-activating injection, an acanthopanax senticosus injection, a Shuanghuanglian injection, a bupleurum injection and the like. By combination of traditional Chinese medicine and western medicine and according to the practical medical treatment principle of treating cancer caused by three accumulated poisons (heat toxin, damp toxin and drug toxin), treatment effect is remarkable, cost is low, normal cells of human body will not be hurt, human immune function is reinforced, metabolism is promoted, and healing confidence of patients is enhanced.

The invention relates to a traditional Chinese veterinary medicine compound preparation Shuanghuanglian for injection as well as a preparation technology and an application thereof. The compound preparation comprises the components in parts by weight as follows: 1300-1700 parts of honeysuckle, 1300-3700 parts of radix scutellariae and 2500-7500 parts of fructus forsythiae. Slow-release accessories comprise 150 parts of hydroxymethyl propyl cellulose and 100 parts of sodium carboxymethyl cellulose. The compound preparation contains the slow-release accessories, so that the injection time of large animals can be reduced, and the stress response of the large animals can be reduced. The traditional Chinese veterinary medicine compound preparation for injection has antiviral, antibacterial, anti-inflammatory, antipyretic, analgesic, immunity-improving effects and the like. Veterinarian clinic proves that the compound preparation can be used for treating epidemic diarrhea; transmissible gastroenteritis; necrotic enteritis; septicemia caused by various epidemic diseases; cough, dyspnea, skin cyanosis, arthrocele which are caused by chromic respiratory diseases such as streptococcosis, haemophflussuis, contagious porcine pleuropneumonia, swine plague and the like; and porcine reproductive and respiratory syndrome and cow mastitis.

The invention discloses a veterinary Shuanghuanglian oral liquid preparation processed by using probiotics. Secondary strains of functional microbes are inoculated to fermentation liquid of a Shuanghuanglian formula, and deep high-density fermentation of liquid is performed at normal temperature under normal pressure by using the life action of the functional microbes to sufficiently and effectively dissolve and convert active ingredients in the Shuanghuanglian formula, thus obtaining the Shuanghuanglian oral liquid biological preparation. The invention also provides a preparation method of the veterinary Shuanghuanglian oral liquid preparation at the same time. The Shuanghuanglian formula is screened as a Chinese medicinal formula, and the antibacterial, antivirus and heat clearing active ingredients included in the Shuanghuanglian formula are furthest extracted by using the functional microbes including lactobacillus acidophilus and candida utilis, so that the curative effect is enhanced. Meanwhile, the lactobacillus acidophilus and the candida utilis can play a role in maintaining and regulating the balance of gastrointestinal microbiota of animals.

The invention provides a method for determining the content of chemical components in a traditional Chinese medicine compound preparation, belongs to the technical field of Chinese patent medicine content determination, and aims to detect the components with greatly different contents in traditional Chinese medicines, accurately determine the contents of high-content components and low-content components in the same traditional Chinese medicine sample and judge the mass change of the traditional Chinese medicines. The traditional Chinese medicine is Shuanghuanglian injection. In order to solve the problem of simultaneous determination of components with great content differences in a traditional Chinese medicine complex system, a multiple dilution method is constructed, a test solution with a low dilution ratio is prepared to detect low-content components (21 components such as neochlorogenic acid), and a test solution with a high dilution ratio is prepared to detect high-content components (baicalin). Rapid detection of components with great content differences in the sample is realized through different dilution methods. The dilution ratio and dilution times of the test solution can be determined according to the content difference degree of the detection components in the to-be-detected sample. The method effectively solves the problem of detection of the components with the content difference.

The invention relates to a compound Shuanghuanglian granular preparation for a pet and a preparation method of the preparation. The compound Shuanghuanglian granular preparation for the pet is prepared from traditional Chinese medicine composition including flos lonicerae, radix scutellariae, fructus forsythia, radix aucklandiae, fructus aurantii, cortex magnoliae officinalis, radix et rhizoma rhei and the like as well as a pet palatable corrective and an auxiliary, has the efficacy of clearing away heat and toxic materials, eliminating dampness with aromatics, invigorating stomach and relieving stasis and particularly has a good clinical control effect on feline distemper.

The invention discloses a Shuanghuanglian oral liquid for preventing and treating infectious laryngotracheitis and belongs to the technical field of poultry medicine. The Shuanghuanglian oral liquid is prepared from 100-400 parts by weight of honeysuckle, 100-400 parts by weight of radix scutellariae, 500-1000g of fructus forsythiae, 100-200 parts by weight of folium polygoni tinctorii, 100-200 parts by weight of blackberry lily, 0.1-1 part by weight of sodium selenite and 10-100 parts by weight of vitamin E. A preparation method of the Shuanghuanglian oral liquid utilizes sodium humate as a solvent and an ultra-high pressure crushing technology. The Shuanghuanglian oral liquid can be used for preventing and treating viral diseases such as infectious laryngotracheitis in poultry, replacesthe anti-viral chemical medicine, has remarkable curative effects and fully produces the best pharmacological effects of the classic Shuanghuanglian prescription.

The invention discloses an orally disintegrating tablet of 'Shuanghuanglian' and its preparation characterized in that the tablet comprises the significant portions extracted from traditional Chinese medicinal honeysuckle flower, baikal skullcap root, capsule of weeping forsythia and other medical use findings, the invention is also characterized that composite disintegrating tablet containing tetrahydroxy butane is employed, wherein the composite disintegrating tablet is obtained by combining tetrahydroxy butane with low substituted Hydroxypropylmethyl cellulose or sodium carboxymethylstarch or crossbond sodium carboxymethylstarch or insoluble cross bond polyvinylpyrrolidone by a finite proportion, the tetrahydroxy butane has the action of taste rectifying agent, thus reducing the consumption of medicinal findings in the preparation. Pharmacological experiment has shown that the disintegrating tablet has the advantages of quick disintegration, fast effect, and better pharmacological actions.

The invention discloses a method for refining a Shuanghuanglian preparation by using a membrane separation technology. The method comprises the following steps: A. preparing water extract: weighing honeysuckle flower, radix scutellariae and fructus forsythiae according to a prescription, and carrying out water extraction on the weighed materials for later use; B. refining by a ceramic membrane: adding the water extract into a ceramic membrane device for continuously filtering, and collecting filtrate, wherein the pore sizes of a filtration membrane of the ceramic membrane device are 400-500nm;C. directly using the filtrate obtained in the step B as liquid medicine to leave factory, or taking the filtrate as a raw material to prepare extract, tablet, powder, granules, injection and suppository. The treatment method provided by the invention enables the efficacy of the original Shuanghuanglian water extract to be effectively improved; in particular, the 450nm film determined by means ofseries of research and development has the best comparative advantages and practical effects in terms of parameters such as extract yield, chlorogenic acid content, baicalin content, forsythin content, membrane flux and interception performance.

The invention relates to application of a Shuanghuanglian preparation in virus infection resistance. Specifically, the invention provides an application of a chlorogenic acid compound or a pharmaceutically acceptable salt or an extract of the chlorogenic acid compound. Experiments show that the Shuanghuanglian preparation (oral liquid) and the active ingredient chlorogenic acid thereof have obvious antiviral effects on severe acute respiratory syndrome coronavirus (SARS-CoV), influenza virus (influenza virus), Middle East Respiratory Syndrome (MERS) and 2019-nCoV (new coronavirus), and prove that the Chinese patent medicine Shuanghuanglian preparation (oral liquid) can be used for treating virus infectious diseases.

The invention relates to the field of veterinary medicines, and discloses a veterinary Shuanghuanglian preparation and a preparation method for the same. The raw material medicine of the veterinary Shuanghuanglian preparation disclosed by the invention is composed of the components in parts by weight: 1 part by weight of honeysuckle, 1 part by weight of scutellaria baicalensis, 2 parts by weight of fructus forsythiae, and 2 parts by weight of astragalus mongholicus. According to the invention, astragalus mongholicus is added based on the traditional Shuanghuanglian prescription, so that the veterinary Shuanghuanglian preparation prepared in this way is higher in pharmaceutical effect. Simultaneously, the preparation method for the veterinary Shuanghuanglian preparation adopts a method combining microwave with extrusion, thus the extraction rate of the active ingredients of each constituent is remarkably increased.

The invention discloses an external traditional Chinese medicine for preventing and treating COVID-19 and a preparation method of the external traditional Chinese medicine. The external traditional Chinese medicine comprises 25-30g of celandine, 25-30g of Melothria heterophylla, 25-30g of galium aparine, 25-30g of flos cleistocalycis, 25-30g of Nauclea officinalis, 25-30g of Drymoglossum subcordatum Fee, 25-30 g of adiantum capillus-veneris, 25-30 g of Adiantum flabellulatum, 25-30 g of Chinese wolfberry, 25-30 g of fructus forsythiae, 25-30 g of herba andrographitis, 25-30 g of Indian damnacanthus herb, 25-30 g of glechoma longituba, 25-30 g of radix scutellariae, 25-30 g of pyrrosia lingua, 25-30 g of honeysuckle, 25-30 g of rheum officinale, 25-30 g of Shuanghuanglian, 25-30 g of flos chrysanthemi indici, 25-30 g of herba lobeliae chinensis, 25-30 g of gypsum, 25-30 g of Aster ageratoides and 25-30 g of trollflower. The invention further discloses a preparation method of the external traditional Chinese medicine for preventing and treating COVID-19. The external traditional Chinese medicine for preventing and treating COVID-19 is a pure traditional Chinese medicine preparation and is an external medicine, a patient can use the external traditional Chinese medicine at home by himself / herself, an external shower mode is adopted, and the method is simple, convenient, free of toxic and side effects and suitable for application and popularization.

The invention discloses a chicken feed for improving disease resistance and survival rate, a preparation method and a feeding method thereof. The chicken feed comprises the following raw materials: corn, soybean meal, rice bran, peanut bran, bone meal, calcium, phosphorus, magnesium and Chinese herbal medicines. The Chinese herbal medicines comprise lucid ganoderma, red dates, astragalus membranaceus, lonicera japonica, lophatherum gracile, radix isatidis, codonopsis pilosula, hedyotis hedyotidea, sculellaria barbata, alpinia japonica, medlar, gardenia jasminoides ellis, mussaenda pubescens, senecio scandens, momordica grosvenori, folium isatidis, orange peel, Shuanghuanglian, radix bupleuri, sweet wormwood, platycodon grandiflorum, liquorice and plantain herb; the raw materials are smashed into powder, and the feed is prepared through stirring, mixing and sealed fermentation; and the prepared feed is fed twice in the morning and evening. The chicken feed can effectively improve the disease resistance and survival rate of the hang chickens, enhance the immunity of chicken bodies, improve the taste of meat, and is free of toxic and harmful substance residues, environment-friendly and healthy.

The invention discloses a Shuanghuanglian pill and process of preparation, wherein the pill includes the aqueous extracts and plasticizers of the following raw materials (by weight portions): weeping forsythia 2 parts, root of large-flowered skullcap 1 part, honeysuckle flower 1 part, and plasticizer 0.13-1.1 part.

The invention provides a method for preparing an injection, comprising that extracting respectively the scutellaria root, honeysuckle flower and capsule of weeping forsythia, then preparing the injection. The invention also provides a component check method of the injection, for improving the quality control level, assure the treatment effect, and support the product detection.

The invention discloses a preparation method of Shuanghuanglian powder injection for injection, which relates to a preparation method of traditional Chinese medicine freeze-dried injection. The existing freeze-drying method has the defects that the drug quality is not easy to control and the yield is not high, and the prepared drug has poor clinical curative effect and many adverse reactions. According to the preparation method of the present invention, the ratio of 1 part of honeysuckle, 2 parts of forsythia and 1 part of scutellaria baicalensis is used to prepare materials, and then the three kinds of raw materials are respectively extracted and then mixed for preparation to obtain Shuanghuanglian powder injection for injection. The Shuanghuanglian powder injection prepared by the freeze-drying method of the present invention is dried at a low temperature, so the active ingredients of the medicine are not easy to be destroyed, the clinical curative effect is good, and the medicine particles maintain the original state and are easy to dissolve; the injection produced by the method of the present invention Shuanghuanglian powder injection has good clinical curative effect and few adverse reactions, which is conducive to popularization and application.

The invention discloses a method for detecting quality of Shuanghuanglian of veterinary Shuanghuanglian oral liquid based on a spectrum-activity relationship. The method comprises the following steps: (1) establishing an HPLC fingerprint spectrum of the veterinary Shuanghuanglian oral liquid; (2) extracting characteristic chromatographic peaks; (3) determining the anti-inflammatory effect of the veterinary Shuanghuanglian oral liquid; and (4) establishing spectrum-activity correlation analysis by adopting a grey correlation analysis method so as to evaluate the anti-inflammatory activity of the characteristic peak. The method has the advantages of simplicity, high objectivity and the like, and is beneficial to quality control of the veterinary Shuanghuanglian oral liquid.

The invention discloses a method for detecting sulfadimidine in veterinary Shuanghuanglian oral liquid, belongs to the technical field of detection methods, and solves the problems of inaccurate detection result of a sample and overhigh detection limit of a detection method due to turbidity of the sample in an existing detection method. The detection method comprises the following steps: S1, adding deionized water and acetonitrile into a to-be-detected sample to obtain an extracting solution; S2, adding sodium chloride into the extracting solution, uniformly mixing, oscillating, and centrifuging to obtain a supernatant 1; S3, subjecting the supernatant 1 to nitrogen blowing to obtain residue; S4, adding a mixed solution of a phosphate buffer solution and methanol into the residues, and uniformly mixing the liquid to obtain a redissolved solution; and S5, centrifuging the redissolved solution, filtering the liquid through a micro-filtration membrane to obtain a supernatant 2, filteringthe supernatant 2, and carrying out liquid chromatography tandem mass spectrometer detection. The detection method has the advantages of being low in detection limit and accurate in detection.

The invention relates to a preparation method of a Chinese patent medicine, in particular to a preparation method of a Chinese patent medicine for intensively preventing 2019-nCoV infection, which sequentially comprises the following steps: a, extracting essential oil of five traditional Chinese medicines, namely Shuanghuanglian, indigo naturalis, radix bupleuri, aster tataricus and liquorice, byadopting a low-concentration 50% hydrous ethanol pressurized steam distillation extraction method; b, performing ultrasonic extraction on extracted medicine residues, folium isatidis, radix isatidis,cyrtomium fortunei, radix paeoniae rubra, scaphium scaphigerum and cortex moutan in a water solvent to obtain a water extract; c, wrapping the extracted essential oil with edible flour to obtain an essential oil edible flour inclusion compound; and d, adding starch into the water extract obtained in the step b and the essential oil edible flour inclusion compound obtained in the step c, granulating, pressing into a Chinese patent medicine, and coating with a film to obtain the product. Effective components in a medicinal material structure can be rapidly separated out, the chemical molecular structure of the effective components cannot be damaged, and the extraction efficiency is sufficient. The technology provided by the step c can efficiently retain the retention efficiency of volatile antiviral components in the medicinal materials in the preparation.

The invention belongs to the technical field of medicine preparation, and particularly relates to a method for preparing veterinary Shuanghuanglian oral liquid, which comprises the following steps: mixing a honeysuckle extracting solution, a fructus forsythiae extracting solution and a radix scutellariae extracting solution according to a weight ratio of 1: 1.5: 1, and then feeding into a preparation device for processing and producing. The preparation device comprises a mixing cylinder, wherein an inner cylinder is arranged inside the mixing cylinder, a base is arranged below the mixing cylinder, the outer wall of the mixing cylinder is fixedly connected with an externally-attached sleeve, the outer wall of the externally-attached sleeve is fixedly connected with three equidistant wheel rings, the inner wall of the base is provided with three equidistant sliding grooves, and the three wheel rings on the externally-attached sleeve are movably connected with the three sliding grooves in the base respectively. According to the present invention, the added raw material liquid is rotationally mixed by using the rotating mixing cylinder, such that the overall mixing effect of the raw material liquid is improved, and the problems of insufficient mixing and pungent smell emission caused by stirring and mixing of the raw material liquid in the existing pharmaceutical process are solved.