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Chinese medicine Shuanghuanglian ointment and its quality control method

A quality control method and ointment technology, which is applied in ointment delivery, pharmaceutical formulations, testing pharmaceutical preparations, etc., can solve problems such as easy irritation, high production cost, and slow absorption of active ingredients

Inactive Publication Date: 2006-11-08
于结妹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Traditional suppositories are inconvenient to use, and the active ingredients are absorbed slowly. Because they are used for a long time, they are prone to irritation, and the production cost is also high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0022] Experimental example 1 Screening experiment of ointment base

[0023] Shuanghuanglian ointment is used to treat colds caused by exogenous wind-heat, symptoms include fever, cough, sore throat; upper respiratory tract infection, pneumonia and other diseases. Among the bases of ointments, the water-soluble base is soluble in water, and generally releases drugs quickly, is non-greasy, easy to spread, non-irritating to skin and mucous membranes, easy to clean, and does not stick to clothes. To sum up, the water-soluble base is selected as the base of Shuanghuanglian ointment. Among the water-soluble matrices, polyethylene glycols are the most common, as well as glycerin gelatin, starch glycerin, cellulose derivatives, carbopol, etc. Formulation screening and stability experiments were carried out on several water-soluble matrices. Ointments are divided into solution type ointments and suspension type ointments due to the different dispersion states of drugs in the matrix....

experiment example 2

[0031] Experimental Example 2 Compatibility Test of Main Drug and Matrix

[0032] After the polyethylene glycol base and the main drug were made into an ointment according to the usual concentration, it was placed in an airtight container and stored under different experimental conditions for one month. The physical properties and baicalin content were used as indicators to observe whether the base was damaged. Whether the drug content changes and whether the ointment is stable. The experimental conditions are as follows (1) oven (40±1°C) (2) room temperature (25±3°C) (3) refrigerator (0±2°C). The experimental results are shown in Table 2.

[0033] Experimental conditions

[0034] Conclusion: The content of the main drug has not changed, and there is no incompatibility with the matrix, and the ointment made is very stable.

experiment example 3

[0035] Experimental Example 3 The selection of the crushing degree of the main drug

[0036] Because Shuanghuanglian ointment is a suspension ointment, the insoluble solid drug should be ground into a fine powder by an appropriate method to ensure that the particle size meets the requirements. Therefore, after the solid drug was pulverized, sieves with different apertures were selected to obtain fine powders of different particle sizes, and after being made into ointment, the ointment was examined by physical properties such as particle size and appearance, and the results are shown in Table 3.

[0037] Experimental conditions

[0038] Conclusion: The ointment prepared from the ultrafine powder obtained by passing the main ingredient through a 200-mesh sieve is fine and uniform, and the particle size meets the regulations.

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PUM

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Abstract

The present invention relates to Chinese medicine Shuanghuanglian ointment and its quality control method. The preparation process of Chinese medicine Shuanghuanglian ointment includes the following steps: decocting, filtering and alcohol extracting skullcap root, honeysuckle and forsythia separately to obtain water solution; mixing the water solution, regulating pH to 5.0-9.0, decompression concentrating, low temperature drying and crushing to obtain medicine powder; dissolving polyethylene glycol-400, polyethylene glycol-6000 and ethyl hydroxyl benzoate in water bath at 40-80 deg.c, adding the medicine powder gradually while stirring and lowering the temperature to room temperature to form ointment; and packing in tube. The Chinese medicine Shuanghuanglian ointment has determined curative effect.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine ointment and a quality control method thereof, in particular to a traditional Chinese medicine Shuanghuanglian ointment and a quality control method thereof for treating diseases such as cold, upper respiratory tract infection and pneumonia caused by exogenous wind-heat. Background technique: [0002] Traditional suppositories are inconvenient to use, and the active ingredients are absorbed slowly. Because they are used for a long time, they are prone to irritation, and the production cost is also high. Ointment overcomes the above-mentioned shortcomings and deficiencies of suppository, and is conducive to the contact of medicine with the affected part. It only needs to be smeared during use, and the active ingredients are dissolved rapidly and distributed evenly. The use of a suitable matrix is ​​conducive to the release and absorption of active ingredients, and more fully exerts the curative ef...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61K9/06A61P11/00A61P31/00G01N30/02G01N30/90G01N33/15
Inventor 于结妹
Owner 于结妹
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