Pharmaceutical composition for treating and preventing respiratory tract viral infection, its preparation process and application

A technology of virus infection and composition, applied in the field of pharmaceutical composition and its industrial preparation, can solve problems such as no experimental data support, and achieve the effects of unique medicinal effect, reduction of lung index value, and reduction of lung lesions

Inactive Publication Date: 2006-02-15
石洪波
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The third page of the CN 96110520.8 specification only mentions "better than anti-influenza virus", but no specific experimental data support

Method used

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  • Pharmaceutical composition for treating and preventing respiratory tract viral infection, its preparation process and application
  • Pharmaceutical composition for treating and preventing respiratory tract viral infection, its preparation process and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Prescription: Bupleurum 481g, Forsythia 481g, Scutellaria baicalensis (wine roasted) 240.5g, wild chrysanthemum 240.5g, honeysuckle 240.5g, bitter almond (fried) 192.4g, soluble starch 454g, starch 91g, appropriate amount of β-cyclodextrin. Make 1000g granules (10g / bag); Dosage: 3 times a day, 1-2 bags each time, clearing away heat and detoxification, and treating wind-heat and cold mainly.

[0044] 1. Take honeysuckle, wild chrysanthemum, forsythia, skullcap, Bupleurum and bitter almond decoction pieces.

[0045] 2. Extract volatile oil: Put the pulverized forsythia, Bupleurum and wild chrysanthemum in the HA220-40-48 supercritical extraction device according to the proportion of the prescription, and use CO 2 For supercritical extraction of volatile oil, the best extraction conditions are extraction pressure 25MPa, extraction temperature 40°C, separation tank I pressure 6MPa, analysis temperature 40°C, separation tank II pressure 5MPa, analysis temperature 40°C, and e...

Embodiment 2

[0053] Prescription: Wild Chrysanthemum 5g, Bupleurum 10g, Forsythia 10g.

[0054] Weigh Bupleurum (40 mesh), Forsythia (20 mesh) and wild chrysanthemum (20 mesh) in the prescription ratio and place them in a supercritical extraction device, adjust the extraction pressure to 20MPa and the extraction temperature to 40°C, and extract after the instrument is stable After 2.5 hours, the extract was received at the discharge port, the weight of the extract was weighed, and compared with the theoretical content calculated under the optimal extraction conditions, the yield was 95.58%.

[0055] Weigh 2g of β-CD (β-cyclodextrin), put it in a mortar, then measure 8ml (4 times the amount) of distilled water into the mortar, mix well and grind it into a paste; at the same time, accurately measure 0.5ml of volatile oil ( Dissolve it with absolute ethanol to 2ml, mix well), add it into the β-CD paste with a dropper, and grind while dripping. Grind evenly, dry part of the water in an oven a...

Embodiment 3

[0058] Prescription: Wild Chrysanthemum 10g, Bupleurum 10g, Forsythia 10g.

[0059] Weigh Bupleurum (40 mesh), Forsythia (20 mesh) and wild chrysanthemum (20 mesh) in the proportion of the prescription to extract the volatile oil by conventional steam distillation for 2 hours. The medicinal liquid produced in the process of extracting the volatile oil is concentrated and added to the total extract in spare.

[0060] Weigh 2.0039g of β-CD (β-cyclodextrin), put it in a mortar, then measure 4ml (2 times the amount) of distilled water into the mortar, mix thoroughly and grind it into a paste; at the same time, accurately measure 0.5ml of volatile oil (dissolved in absolute ethanol to 2ml, and mixed), and added to the β-CD paste with a dropper, and ground while dripping. Grind well and dry part of the water in an oven at 40°C, filter, and wash the precipitate with 15ml of petroleum ether three times; the precipitate is dried at 40°C for 4 hours to obtain the clathrate, weighing 1....

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Abstract

Disclosed is a pharmaceutical composition for treating and preventing respiratory tract viral infection, which is prepared from wild chrysanthemum flower 1-5 parts, bupleurum root 1-10 parts, capsule of weeping forsythia 1-10 parts, baikal skullcap root 5-10 parts, honeysuckle flower 5-10 parts and bitter apricot kernel 4-8 parts.

Description

technical field [0001] The invention belongs to a pharmaceutical composition for treating respiratory diseases and its preparation method and application, in particular to a pharmaceutical composition derived from traditional Chinese medicine and capable of treating and preventing respiratory virus infection and its industrially applicable preparation method and application. Background technique [0002] The clinical manifestations of respiratory virus infection are mainly: fever, headache, body pain, sore throat, cough, lung infection and other upper, middle and lower respiratory tract inflammation. Therefore, the ideal drug for the treatment of respiratory virus infection should have antipyretic, antipyretic and Inflammatory, analgesic, and cough-relieving effects. Yet the main cause of disease of falling ill is that human body is infected with virus, so, the medicine of this rational treatment respiratory virus infection must have antiviral effect. The main viruses of re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61P31/12A61P11/00A61P29/00
Inventor 石洪波
Owner 石洪波
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