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Nano 'Shuang Hualian' injection preparation for fowl and preparation thereof

An injection preparation, Shuanghuanglian technology, applied in the field of poultry nano Shuanghuanglian injection preparation and preparation thereof, can solve the problems of unsatisfactory treatment effect, poor absorption effect, inconvenient use, etc., achieves enhancement of humoral immunity and cellular immunity, promotion of The effect of restoring feed intake and improving compliance

Inactive Publication Date: 2009-01-21
TIANJIN SHENGJI GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] If Chinese medicinal raw materials are used to make tablets, powders, etc., due to the short half-life of water-soluble active ingredients in some Chinese medicinal materials, frequent administration is required, so it is inconvenient to use; at the same time, the absorption effect is not good, and the therapeutic effect is not ideal.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take 300g of Coptis chinensis, 250g of honeysuckle, 150g of Forsythia, 300g of Scutellaria baicalensis, decoct the crushed honeysuckle, forsythia, and Coptis chinensis twice in water, add 7 times the amount of water each time, for 2 hours each time, combine the decoction liquid, filter After the filtrate is concentrated to 900ml, add 95% ethanol to make the alcohol concentration reach 70%, let it stand for 12 to 24 hours, filter, and reclaim ethanol; continue to concentrate into extracts of honeysuckle, berberine, and forsythia; the pulverized Scutellaria baicalensis, Add water to decoct twice, add 6 times the amount of water each time, extract in turn for 2 hours and 1 hour, combine the filtrate, and when it is concentrated to about 1500ml, add 95% ethanol to make the alcohol concentration 60%, let it stand for 12-24 hours, filter After filtration, ethanol is recovered from the filtrate, and when it is concentrated to about 400ml, add 95% ethanol to make the alcohol con...

Embodiment 2

[0038] Take 120g of Coptis chinensis, 160g of honeysuckle, 380g of forsythia, and 340g of Scutellaria baicalensis, decoct the crushed honeysuckle, coptis, and forsythia in water twice, add 7 times the amount of water each time, for 2 hours each time, combine the decoction liquid, filter After the filtrate is concentrated to 900ml, add 95% ethanol to make the alcohol concentration reach 70%, let it stand for 12 to 24 hours, filter, and reclaim ethanol; continue to concentrate into extracts of honeysuckle, berberine, and forsythia; the pulverized Scutellaria baicalensis, Add water to decoct twice, add 6 times the amount of water each time, extract in turn for 2 hours and 1 hour, combine the filtrate, and when it is concentrated to about 1500ml, add 95% ethanol to make the alcohol concentration 60%, let it stand for 12-24 hours, filter After filtration, ethanol is recovered from the filtrate, and when it is concentrated to about 400ml, add 95% ethanol to make the alcohol concentra...

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Abstract

The invention relates to a nano Shuanghuanglian injection used for poultry and a preparation method thereof; the nano Shuanghuanglian injection consists of 3-55% of Chinese medicinal material extracts which are taken as active ingredients and 41-90% of biodegradable medicinal high-molecular excipients which have microsphere weight and have molecular weight ranging from 4,000 to 9,000,000 by weight proportion; wherein, the weight percentage of medicinal materials is as follows: 10-42% of Chinese goldthread, 10-50% of honeysuckle, 10-40 % of forsythia and 10-38% of radix scutellariae. The medicines are prepared into microspheres by spray drying process. The invention has the benefical effects of (1) developing a new medicine for preventing and treating poultry viral diseases for clinical application; (2) reasonable prescription and strong antiviral ability; (3) advanced technique, stable preparation and long storage time; (4) broad medicine sources and no toxicity and side effect. Especially, the nano Shuanghuanglian injection has significant effect on the treatment of poultry infectious bursal disease, untypical Newcastle disease, infective bronchitis, etc.

Description

technical field [0001] The invention relates to the field of medicine for treating animal diseases, in particular to a poultry nano Shuanghuanglian injection preparation and a preparation method thereof. Background technique [0002] At present, in the treatment of poultry viral diseases, antibiotics are usually the main treatment, which not only has relatively large toxic and side effects, such as certain side effects on the liver and kidney functions of poultry, which will easily cause drug residues in the poultry body; it will also pollute the environment, and the treatment The cost is higher. [0003] Motherland medicine believes that Scutellaria baicalensis can be used alone or in combination with other medicinal materials to achieve the desired clinical effect. Shuanghuanglian is a traditional Chinese medicine preparation whose main ingredients are honeysuckle, berberine and forsythia. The double flower is honeysuckle, which is cold in nature, sweet in taste, and fra...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61K9/10A61K9/16A61K47/34A61P11/00A61P31/14A61K47/10
Inventor 田杏芳王连民
Owner TIANJIN SHENGJI GRP CO LTD
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