48results about How to "Prolonged cough latency" patented technology

The invention aims to develop medicinal composition fat emulsion injection containing eucalyptol, limonene and alpha-pinene and a preparation method. The preparation comprises the following components in percentage by weight: 0.0128 to 0.0320 percent of eucalyptol, 0.0084 to 0.0210 percent of limonene, 0.0028 to 0.0070 percent of alpha-pinene, 10 to 30 percent of soybean oil for injection, 1.0 to 1.5 percent of yolk lecithin for injection or 0.8 to 1.5 percent of soybean phospholipids for injection, 2.0 to 2.5 percent of glycerol for injection, and water for injection added to 100 milliliters. The preparation method has the characteristics of strong controllability of production quality, and definite treatment effect of a product. The invention fills up the blank of the medicinal composition fat emulsion injection preparation containing the eucalyptol, the limonene and the alpha-pinene.

A Chinese medicine in the form of capsule, stable, particle, or oral liquid for treating pulmonary heart disease is prepared from 3 Chinese medicinal materials including astragalus root, red peony root and psoralea fruit through decocting twice (each time for 1 hr.), filtering, concentrating up to relative density of 1.05-1.15 at 80 deg.C, depositing in alcohol standing still for 24 hr, recovering alcohol, continuously concentrating up to relative density of 1.35-1.40 at 80 deg.C concentrating, mixing with red peony root powder, stirring, drying, pulverizing and granulating.

The invention discloses a traditional Chinese medicine preparation, including the traditional Chinese medicine active ingredients and the pharmaceutically acceptable amount of medicinal excipients, the unibract fritillary bulb is smashed into coarse powder, and the unibract fritillary bulb extract liquid is obtained by collecting the percolation liquid and recycling the ethanol according to the percolation methods under the fluid extract and the extract items (appendix IO of Part one of Chinese pharmacopeia 2005 version); the pummelo peel, dried ginger and liquoric root are respectively immersed by ethanol solution and filtered, the filtrate is subject to ethanol recycling and is condensed into thick paste A; the loquat leaf, coastal glehnia root, Indian buead, platycodon root, rhizoma pinelliae preparata, snakegourd fruit and bitter apricot seed are boiled by adding water for 2 to 3 times and 1 to 3 hours for each time, the decoction solution is merged, placed still and filtered, the filtrate is evenly mixed with unibract fritillary bulb extract liquid and the thick paste A, then the menthol ethanol solution and apricot water are added for even mixing, and the medicinal excipients are added to prepare the preparation. The traditional Chinese medicine preparation which is prepared by the invention has the advantages of significant efficacy, high bioavailability, rapid onset of action, convenient administration and easy acceptation by patients, and the invention can be used for the treatment of cough, expectoration or ungratifying expectoration, dry pharynx and mouth and other symptoms.

The invention relates to a traditional Chinese medicine oral liquid for rapidly relieving cough. The composition is prepared by the following active ingredients in ratios by weight: 12-16 parts of loquat leaf, 5-8 parts of corn stigma, 18-25 parts of fresh ginger, 15-20 parts of rhizoma polygonati, 15-20 parts of liquorice, 12-18 parts of lily, 12-18 parts of platycodon grandiflorum, and 45-60 parts of crystal sugar. The traditional Chinese medicine oral liquid disclosed by the invention can rapidly relieve cough, and is remarkable in curative effect and high in safety.

A Chinese medicine for treating cough and asthma is prepared from 4 Chinese-medicinal materials including scutellaria root, platycodon root, phabitis seed, etc. Its advantages are high curative effect, no toxic by-effect and low cost.

The invention relates to a Shuanghuanglian soluble powder preparation technique. The Shuanghuanglian soluble powder is prepared by the following medicines with parts by weight: 800 to 1000 parts of honeysuckle, 800 to 1000 parts of radices scutellariae and 1600 to 2000 parts of fructus forsythiae; the preparation technique is characterized by comprising the steps of decocting the honeysuckle with water for two times (one hour for the first time and 45 minutes for the second time), collecting decoction, decocting the radices scutellariae with water for three times, collecting decoction, filtering, concentrating filter liquid, drying under reduced pressure, standby, grinding the fructus forsythiae, adding water and decocting for three times, depositing, filtering, and spray drying concentrated liquid which is then ground into fine powder with the extraction of the honeysuckle and the fructus forsythiae, adding proper grape sugar and obtaining the Shuanghuanglian soluble powder. The Shuanghuanglian soluble powder is characterized by high active component content, slight toxicity and side effect, no drug residues, capability of being used in the mixed feeding and drinking of large-scale culture, convenient storage and transportation, and meets the requirements of new veterinary drug preparations. The Shuanghuanglian soluble powder is applicable to curing livestock infectious diseases with determined curative effect.

The invention discloses a soft capsule of traditional Chinese medicine and a preparation method thereof, comprising traditional Chinese medicine active ingredients and pharmaceutical adjuvant with volume can be accepted in medical science. The invention comprises the following processes: American ginseng and tendrilleaf fritillary bulb are crashed into thick powder and mixed evenly; the mixture is percolated according to percolation (appendix IQ of first part in Chinese pharmacopoeia, 2000 version) under the item of liquid extract and extract; alcohol of the percolated liquid is recovered and the percolated liquid turned into thick paste by decompress concentration; pipa leaf, glehnia root, platycodon root, bitter apricot seed and liquorice are boiled in water; the boiled liquid is combined and filtered; the filtered liquid is concentrated into thick paste; the two kinds of thick paste are mixed evenly; menthol and apricot seed water with right amount dissolved by alcohol are added into the mixture and the mixture is mixed evenly; the soft capsule is prepared by adding pharmaceutic adjuvant with volume can be accepted in the medical science into the mixture.The liquid capsule of traditional Chinese medicine prepared by the invention has the advantages of remarkable treatment effect, high degree of biological utilization, fast effect appearance, small poison adverse reaction, convenient medicine taking and easy for patients. So the capsule can be used for treating cases like cough due to yin deficiency, raphe haryngis and pharyngalgia, little sputum but sticky and tongue red and less fur etc.

The invention discloses a medicine composition capable of preventing and treating chronic obstructive pulmonary diseases. The medicine composition comprises 10-20 parts of radix astragali, 6-12 parts of radix aconiti lateralis preparata, 1-6 parts of herba ephedrae preparata, 3-9 parts of radix salviae miltiorrhizae, 1-6 parts of rhizoma pinelliae, 1-6 parts of fructus schisandrae chinensis, 3-9 parts of radix platycodonis and 1-6 parts of radix glycyrrhizae. The medicine composition has the advantages that effects of warming yang, securing the exterior, relieving cough and asthma, eliminating stagnation and dissolving phlegm can be realized by the medicine composition; the chronic obstructive pulmonary diseases can be treated according to etiology of lung diseases such as chronic bronchitis which cause the chronic obstructive pulmonary diseases, symptoms can be relieved, the medicine composition can become effective fast, the constitution of patients can be improved, the problem of aggravation of diseases due to the fact that patients are easy to catch a cold can be solved, and progression of the diseases can be prevented.

The invention relates to the field of traditional Chinese medicine. A traditional Chinese medicine composition for treating Yin deficiency type cough caused by lung cancer is prepared from active pharmaceutical ingredients in weight proportion as follows: 6-12 g of lilies, 6-12 g of cochinchinese asparagus roots, 6-12 g of fragrant solomonseal rhizomes, 6-12 g of dwarf lilyturf tuber, 6-12 g of adenophora roots, 6-12 g of fructus lycii, 6-12 g of mulberries, 3-9 g of apricot kernels, 6-12 g of common anemarrhena rhizomes, 6-12 g of fritillaria and 3-9 g of liquorice, and preferably, the traditional Chinese medicine composition is prepared from the active pharmaceutical ingredients in weight proportion as follows: 9 g of the lilies, 9 g of the cochinchinese asparagus roots, 9 g of the fragrant solomonseal rhizomes, 9 g of the dwarf lilyturf tuber, 9 g of the adenophora roots, 9 g of the fructus lycii, 9 g of the mulberries, 6 g of the apricot kernels, 9 g of the common anemarrhena rhizomes, 9 g of the fritillaria and 6 g of the liquorice. The invention further discloses an application of the traditional Chinese medicine composition for treating Yin deficiency type cough caused by lung cancer in preparation of a drug for treating Yin deficiency type cough caused by lung cancer. The traditional Chinese medicine composition is a special oral traditional Chinese medicine preparation for the Yin deficiency type cough caused by lung cancer, the selected ingredients are properly compatible, can be effectively matched with lung cancer treatment and have remarkable clinical effects, the medical cost is reduced, and the traditional Chinese medicine composition is actually a classic basic prescription in the field.

The invention discloses an eriosema chinense isoflavoid extract and an extraction method and applications thereof. The eriosema chinense isoflavoid extract has the structure as the right formula, is prepared by separating and purifying through the combination of HSCCC and traditional thin-layer chromatography preparation by using a traditional solvent backflow extraction method, and is one of thenew compounds which are obtained by separating from the petroleum ether part of eriosema chinense medicinal materials. The eriosema chinense isoflavoid extract of the invention has bacteria-resistant,anti-inflammatory, cough-relieving and sputum-resolving functions.

The invention relates to a medicine composition with effects of diminishing inflammation and relieving cough and a method for preparing the medicine composition. The medicine composition comprises, by weight, exocarpium citri grandis, radix stemonae, poria, rhizoma pinelliae, rhizoma cynanchi stauntonii, radix glycyrrhizae, semen armeniacae amarum and fructus schisandrae chinensis. The method for preparing the medicine composition includes distilling the exocarpium citri grandis and the semen armeniacae amarum by the aid of steam; extracting the radix glycyrrhizae and the rhizoma pinelliae by the aid of ethyl alcohol and then extracting the radix glycyrrhizae and the rhizoma pinelliae by the aid of organic solvents; extracting the honey-processed radix stemonae, the honey-processed poria, the honey-processed rhizoma cynanchi stauntonii and the honey-processed fructus schisandrae chinensis by the aid of water; combining extract to obtain the medicine composition. The medicine composition and the method have the advantages that effects of regulating qi-flowing for eliminating phlegm and moistening lungs for relieving the cough can be realized by the medicine composition, and the medicine composition is applicable to the cough, asthma and excessive phlegm due to turbid phlegm obstructing lungs; as observed clinically, definite curative effects are realized by the medicine composition for common cold, bronchitis and faucitis, and toxic and side effects are unfound.

The invention discloses a lily honey paste for preventing and treating respiratory diseases caused by haze, and a preparation method thereof. The product consists of the following Chinese herbal medicinal raw materials in parts by weight: 40 to 60 parts of lily, 20 to 30 parts of pear flower, 10 to 15 parts of astragalus membranaceus, 8 to 12 parts of mangnolia officinalis, 10 to 15 parts of ophiopogon japonicas, 15 to 20 parts of honeysuckle, 10 to 13 parts of white paeony root, 8 to 12 parts of angelica sinensis, 10 to 15 parts of aster, 10 to 16 parts of momordica grosvenori, 10 to 18 parts of platycodon grandiflorum, 5 to 10 parts of schisandra chinensis, 5 to 10 parts of rhizoma anemarrhenae, 10 to 15 parts of licorice root, 10 to 15 parts of stevia rebaudiana and 1,000 parts of honey. The lily honey paste is prepared by adopting the processes of performing ultrasonic wave-assisted extraction, distilling volatile oil, decocting with water, and performing alcohol extraction. The lily honey paste has the advantages of good effect of preventing and treating respiratory diseases caused by haze, safety without side effects, convenience in drinking and the like.

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine combination for treating cough and asthma and a preparation method thereof. The traditional Chinese medicine combination is prepared by, by mass, 15-45 parts of fleshy lysionotus, 15-45 parts of purple bergenia rhizome, 15-45 parts of giant knot weed and 15-45 parts of Yanguo. The preparation method includes: making the four traditional Chinese medicinal materials to be extract through water extraction or water extraction and alcohol precipitation; adding proper auxiliary materials to prepare the extract to be pharmaceutically conventional dosage forms like granules, tablets, pills, capsules or powder. Modern pharmacological study and clinical experiments show that the traditional Chinese medicine combination has efficacy of clearing heat, relieving cough, reducing phlegm and relieving asthma, can be made into a sucrose-free preparation of 4g in dosage for each time, can quickly relieve cough and asthma caused by wind-heat invading lung and phlegm heat accumulation, is convenient to use, remarkable in curative effect, free of toxic and side effect, comfortable and safe, is effective medicine for treating cough and asthma, can be widely used for clinical treatment of cough and asthma and has wide market prospect.

The invention relates to an extraction method of gentiana urnula glycoside A, and applications of gentiana urnula glycoside A in preparation of cough-relieving drugs. The extraction method comprises following steps: Gentiana szechenyii Kanitz or Gentiana urnula H. Smith crude powder is mixed with water, and is subjected to decoction or reflux extraction for 1 to 3 times, 1 to 3h each time, wherein the amount of water is 10 to 50 times of that of the Gentiana szechenyii Kanitz or Gentiana urnula H. Smith crude powder; an obtained mixture is subjected to centrifugation, obtained supernatant is mixed, and is subjected to macroporous resin column adsorption; macroporous resin column elution is carried out with water, 30 to 35% ethanol aqueous solution, and 40% ethanol aqueous solution successively, an elution fraction of the 40% ethanol aqueous solution is collected, and is subjected to condensation so as to obtain a 40% ethanol elution fraction; and the 40% ethanol elution fraction is subjected to gel Sephadex LH-20 column chromatography and silica-gel column chromatography separation, and obtained gentiana urnula glycoside A fractions are mixed so as to obtain a gentiana urnula glycoside A pure product. The gentiana urnula glycoside A can be used for treating cough as a cough-relieving drug, and can be prepared into pharmacologically acceptable dosage forms.

The invention relates to a new application of total schisandra lignans in preparation of medicaments or health-care products for treating cough, and in particular relates to a new application in preparation of medicaments or health-care products for preventing cough, relieving cough and eliminating airway inflammation. Experiments show that the total schisandra lignans can be used for significantly reducing the cough frequency of cavies suffering from increased cough sensitivity caused by cigarette smoke stimulus and acute cough caused by citric acid smog stimulus, prolonging the cough latency and significantly reducing the airway inflammation of the cavies suffering from increased cough sensitivity caused by cigarette smoke stimulus, so that the total schisandra lignans can be used for preparing the medicaments for preventing cough, relieving cough and eliminating airway inflammation.

The invention provides a novel compound capable of effectively antagonizing P2X3 receptor, which is a compound as shown in formula I, tautomers, stereoisomers, hydrates, solvates, pharmaceutically acceptable salts or prodrugs thereof, preparation methods of the novel compound and the tautomers, the stereoisomers, the hydrates, the solvates and the pharmaceutically acceptable salts or the prodrugs thereof, and application of the novel compound in preparation of drugs