Compound bulbus fritilariae and loquat capsule and application thereof

Abstract

The invention relates to the technical field of traditional Chinese medicines, and provides a compound bulbus fritillariae cirrhosae and loquat capsule and application thereof, and the compound bulbus fritillariae cirrhosae and loquat capsule is prepared from the following traditional Chinese medicines: 10-12 g of loquat leaf, 9-10 g of cassia twig, 10-12 g of codonopsis pilosula, 5-6 g of platycodon grandiflorum, 5-6 g of bulbus fritillariae cirrhosae, 5-6 g of pinellia ternate, 5-6 g of pericarpium citri reticulatae, 2-3 g of rhizoma zingiberis and 0.5-1 g of menthol. The compound bulbus fritillariae cirrhosae and loquat capsule improves qi and blood circulation of the lung and the whole body and relieves cold cough and accompanied excessive phlegm symptoms in modes of warming cold dampness, dredging lung qi, enhancing spleen and stomach functions and the like, so that the effects of relieving cough and reducing sputum are achieved, and the compound bulbus fritillariae cirrhosae and loquat capsule is particularly suitable for cough patients stimulated by cold; the traditional Chinese medicinal materials are matched for use, so that the weight of a cold cough mouse can be remarkably improved, the cough latency of the cold cough mouse is remarkably prolonged, the cough frequency of the mouse is reduced, and a remarkable cough relieving effect is achieved; meanwhile, the tracheal phenol red excretion amount of cold cough mice can be remarkably increased, and the remarkable phlegm reducing effect is achieved.

Description

Technical Field

[0001] The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a compound Chuanbei loquat capsule and an application thereof. Background Art

[0002] In the field of TCM treatment of cough, the compound Chuanbei loquat capsule has attracted much attention for its unique effects of clearing the lungs, reducing phlegm, relieving cough and relieving asthma. With Chuanbei, Platycodon grandiflorum, loquat leaves and menthol as the core ingredients, the combination effectively relieves cough symptoms caused by colds, pharyngitis or other respiratory infections through multiple mechanisms of action such as moistening the lungs and relieving coughs, removing phlegm and relieving sore throats. Chuanbei and loquat leaves both have the effects of clearing heat and moistening the lungs, reducing phlegm and relieving coughs. They are commonly used medicinal materials in traditional Chinese medicine prescriptions, and are particularly suitable for relieving symptoms such as dry coughs, little phlegm and thick phlegm.

[0003] However, the application of compound Chuanbei loquat capsules in patients with cold constitution may be subject to certain restrictions. People with cold constitution usually show symptoms such as low body temperature, cold hands and feet, and fear of cold. The medicinal properties of compound Chuanbei loquat capsules are warm. Although it has an improvement effect on patients with cold cough, long-term use may cause imbalance of cold and heat in the body, causing discomfort such as getting angry and dry mouth. When patients with cold constitution use warm cough suppressants for a long time, they may not be able to regulate their constitution well. Instead, it will make it difficult to eliminate the cold and dampness in the body, thus affecting the overall recovery effect.

[0004] In order to overcome the above shortcomings, mild and cold medicinal materials, such as Codonopsis pilosula, Atractylodes macrocephala, etc., can be introduced into the formula of the compound Chuanbei loquat capsule to help enhance the transportation and transformation function of the spleen and stomach, regulate the cold constitution, and prevent the medicine from being too hot. At the same time, medicinal materials with cool properties, such as reed root, bamboo leaf, etc., can also be appropriately added to adjust the overall warm and hot balance of the composition, so that it is more adaptable to patients with cold constitution while regulating cold cough; Cinnamon twigs can be added to the compound Chuanbei loquat capsule to further enhance its effect of warming yang and dispersing cold, making it more suitable for cough caused by cold constitution. These improvements can effectively reduce the sensitive reaction of constitution to the medicine on the basis of retaining its cough and phlegm-relieving effect, broaden its applicable population, and improve the clinical application effect of the drug. Summary of the invention

[0005] In order to solve the above problems, the present invention firstly provides a compound fresh bamboo traditional Chinese medicine composition for relieving cough and its application.

[0006] The invention provides a compound Chuanbei loquat capsule which is prepared from the following raw materials by weight: 10-12g of loquat leaves, 9-10g of cassia twigs, 10-12g of codonopsis pilosula, 5-6g of platycodon, 5-6g of fritillaria cirrhosa, 5-6g of pinellia tuber, 5-6g of tangerine peel, 2-3g of dried ginger and 0.5-1g of menthol.

[0007] In some embodiments, the Chinese medicine composition is prepared from the following raw materials by weight: loquat leaf 12g, cinnamon twig 10g, Codonopsis pilosula 12g, Platycodon grandiflorum 5g, Fritillaria 6g, Pinellia 6g, Tangerine peel 5g, Dried ginger 2g, and menthol 0.5g.

[0008] In some embodiments, the Chinese medicine composition is prepared from the following raw materials by weight: loquat leaf 10g, cinnamon twig 10g, Codonopsis pilosula 10g, Platycodon grandiflorum 6g, Fritillaria 5g, Pinellia 5g, Tangerine peel 6g, Dried ginger 2g, and menthol 1g.

[0009] In some embodiments, the Chinese medicine composition is prepared from the following raw materials by weight: loquat leaf 12g, cinnamon twig 9g, Codonopsis pilosula 12g, Platycodon grandiflorum 6g, Fritillaria 5g, Pinellia 6g, Tangerine peel 6g, dried ginger 3g, and menthol 1g.

[0010] In some embodiments, the Chinese medicine composition is prepared from the following raw materials by weight: loquat leaf 12g, cinnamon twig 10g, Codonopsis pilosula 10g, Platycodon grandiflorum 5g, Fritillaria 6g, Pinellia 6g, Tangerine peel 6g, dried ginger 2g, and menthol 0.5g.

[0011] In some embodiments, the Chinese medicine composition is prepared from the following raw materials by weight: loquat leaf 12g, cinnamon twig 10g, Codonopsis pilosula 12g, Platycodon grandiflorum 5g, Fritillaria 6g, Pinellia 6g, Tangerine peel 6g, dried ginger 2g, and menthol 0.5g.

[0012] In addition, the present invention also provides an application of a traditional Chinese medicine preparation in preparing a medicine for treating cough.

[0013] The compound Chuanbei loquat capsule of the present invention is used to treat cold irritation cough, and its formula contains loquat leaf, cinnamon twig, codonopsis, platycodon, fritillaria, pinellia, tangerine peel, dried ginger and menthol. The combination of these ingredients, through their own unique pharmacological effects, jointly exerts the effects of relieving cough, resolving phlegm, warming the middle and expelling cold. The mechanism of action of each ingredient in treating cold cough is explained in detail below:

[0014] The main drug is the main drug in the formula, directly targeting the cause of the disease:

[0015] Loquat leaves: have the effects of clearing lungs, relieving coughs and reducing phlegm. Loquat leaves can clear lung heat, regulate lung function, moisten the lungs, relieve asthma, and relieve coughs caused by cold stimulation.

[0016] Cinnamon twig: warms the meridians and dispels cold, and dredges the meridians. Cinnamon twig can dispel cold and dredge yang, and is particularly suitable for lung qi stagnation caused by cold evil. Its warming effect helps to relieve the oppression of cold air on the lungs and restore the smoothness of the lung qi.

[0017] Codonopsis: tonifies the middle qi, nourishes the lungs and moistens dryness. Codonopsis strengthens the spleen and stomach functions, helps the formation of qi and blood, makes the lungs full of qi, and enhances the body's resistance. For coughs caused by cold constitution, the effect of Codonopsis can regulate the constitution and improve lung function.

[0018] Minister drugs assist monarch drugs and jointly enhance the therapeutic effect:

[0019] Platycodon grandiflorum: It can clear the lungs, relieve sore throats, and eliminate phlegm. Platycodon grandiflorum is effective in relieving cough and reducing phlegm. It can clear the lungs and help eliminate phlegm. Platycodon grandiflorum has a good effect on improving the thick phlegm caused by cold cough.

[0020] Fritillaria cirrhosa: clears heat and resolves phlegm, moistens the lungs and relieves cough. Fritillaria cirrhosa can clear heat and resolve phlegm without damaging the vital energy, helping to relieve coughs caused by cold stimulation, and has a significant effect in moistening the lungs.

[0021] Pinellia: Drying dampness and resolving phlegm, relieving adverse reactions and stopping vomiting. Pinellia is good at drying dampness and resolving phlegm, and is suitable for patients with cold cough accompanied by phlegm and dampness. It can dredge the airways and reduce the frequency and severity of coughs.

[0022] Tangerine peel: regulates qi and resolves phlegm, strengthens the spleen and harmonizes the stomach. Tangerine peel can regulate qi and regulate the middle, resolve phlegm and relieve cough, and help improve chest tightness and qi stagnation associated with cold cough. The warming effect of tangerine peel is particularly suitable for cold cough.

[0023] The adjuvant drugs assist the main and secondary drugs to improve the overall efficacy and reduce the side effects of the drugs:

[0024] Dried ginger: warms the middle and dispels cold, restores yang and unclogs the meridians. Dried ginger can warm the middle and dispel cold, and has a direct effect of warming the lungs and dispelling cold for coughs caused by cold constitutions, effectively alleviating airway discomfort caused by cold evil.

[0025] Menthol: dispels wind and heat, and clears the throat. Menthol has a cooling effect and can relieve throat discomfort caused by cold stimulation. Although the overall effect is mainly warming and nourishing, the cooling effect of menthol moderately harmonizes, making the drug effect more peaceful.

[0026] The Chinese medicine composition of the present application achieves the overall effect of warming the middle and dispersing cold, clearing the lungs and resolving phlegm, regulating qi and regulating the middle through the coordination of the main drug, the ministerial drug and the adjuvant drug. Coughs caused by cold stimulation are mostly related to the invasion of cold evil and poor qi movement. The compound Chuanbei loquat capsule improves the circulation of qi and blood in the lungs and the whole body by warming and removing cold and dampness, unblocking lung qi, and enhancing spleen and stomach function, thereby relieving cold cough and its accompanying phlegm symptoms, thereby achieving the effect of relieving cough and resolving phlegm.

[0027] The main herbs loquat leaf, cinnamon twig and codonopsis pilosula work together to dispel cold and warm the lungs, helping the body to dispel the evil cold. The assistant herbs platycodon, fritillaria cirrhosa, pinellia ternata and tangerine peel further dispel phlegm and relieve sore throat, ensure airway patency, and improve lung and spleen function. The auxiliary herbs dried ginger and menthol have the effects of warming the middle and dispelling cold, clearing the lungs and relieving the exterior, effectively promoting the overall cough and phlegm-relieving effect.

[0028] In addition, the combined use of the above-mentioned Chinese medicinal materials can significantly improve the body weight of mice with cold cough, significantly prolong the cough latency period of mice with cold cough, reduce the number of coughs in mice, and have a significant antitussive effect; at the same time, it can significantly increase the tracheal phenol red excretion of mice with cold cough, and have a significant expectorant effect. DETAILED DESCRIPTION

[0029] In order to make the technical problems to be solved, technical solutions and advantages of the present invention more clear, they are described in detail below in conjunction with specific embodiments.

[0030] Example 1

[0031] A compound Chuanbei loquat capsule A is prepared from the following raw materials by weight: 12g loquat leaf, 10g cassia twig, 12g codonopsis pilosula, 5g platycodon, 6g citronella, 6g pinellia tuber, 5g tangerine peel, 2g dried ginger and 0.5g menthol.

[0032] Example 2

[0033] A compound Chuanbei loquat capsule B is prepared from the following raw materials by weight: 10g loquat leaf, 10g cassia twig, 10g codonopsis pilosula, 6g platycodon, 5g citronella, 5g pinellia tuber, 6g tangerine peel, 2g dried ginger and 1g menthol.

[0034] Example 3

[0035] A compound Chuanbei loquat capsule C is prepared from the following raw materials by weight: 12g loquat leaf, 9g cassia twig, 12g codonopsis pilosula, 6g platycodon, 5g citronella, 6g pinellia tuber, 6g tangerine peel, 3g dried ginger and 1g menthol.

[0036] Example 4

[0037] A compound Chuanbei loquat capsule D is prepared from the following raw materials by weight: 12g loquat leaf, 10g cassia twig, 10g codonopsis pilosula, 5g platycodon, 6g citronella, 6g pinellia tuber, 6g tangerine peel, 2g dried ginger, and 0.5g menthol.

[0038] Example 5

[0039] A compound Chuanbei loquat capsule E is prepared from the following raw materials by weight: 12g loquat leaf, 10g cassia twig, 12g codonopsis pilosula, 5g platycodon, 6g citronella, 6g pinellia tuber, 6g tangerine peel, 2g dried ginger and 0.5g menthol.

[0040] Comparative Example 1

[0041] A compound Chuanbei loquat capsule F is prepared from the following raw materials by weight:

[0042] Fritillaria 65g, Platycodon 65g, loquat leaf 430g, and Henao 0.5g.

[0043] The preparation method is as follows: of the above four ingredients, Fritillaria cirrhosa is crushed into fine powder: Platycodon grandiflorum is crushed into fine powder, 48 g is taken, each is used: the coarse head and loquat leaf are decocted twice with 10 times the amount of water, each time for 1 hour, filtered several times, the filtrate is combined, and allowed to stand for 12 hours, the supernatant is concentrated to a clear paste with a relative density of 1.20-1.25 (60°C), mixed with Platycodon grandiflorum powder, dried, ground, Fritillaria cirrhosa powder is added, mixed, made into granules, dried, almond essence, menthol, starch in appropriate amounts, mixed, and put into capsules, each capsule is filled with about 0.3 g to 0.5 g of the powder, and finally the compound Fritillaria cirrhosa and loquat capsule F is obtained.

[0044] Example 6

[0045] A preparation method of compound Chuanbei loquat capsule AF, the specific steps are as follows:

[0046] According to the Chinese medicine formula recorded in Examples 1-5, reasonably weigh loquat leaves, cinnamon twigs, platycodon, Fritillaria cirrhosa, pinellia, tangerine peel, dried ginger and other Chinese medicinal materials that meet the pharmacopoeia standards to ensure that the medicinal materials are dry and free of impurities. Clean the medicinal materials and remove dirt and impurities to prevent pollutants from affecting the efficacy. Slice or crush the cleaned medicinal materials to increase the surface area of ​​the medicinal materials as much as possible to facilitate the subsequent extraction process. Hard medicinal materials such as dried ginger and cinnamon twigs can be crushed into coarse powder, and the remaining medicinal materials can be cut into small pieces. Use pure water as the extraction solvent to extract the active ingredients in the medicinal materials. The extraction ratio is usually 1:10 (weight ratio of medicinal materials: water);

[0047] First extraction: Add loquat leaves, cinnamon twigs, platycodon, Fritillaria cirrhosa, pinellia, tangerine peel, and dried ginger into the extraction tank, add 10 times the amount of water, boil over high heat first, then switch to low heat to maintain boiling state, and boil and extract for 2 hours.

[0048] Second extraction: After the extraction is completed, filter out the medicinal liquid, continue to add water to 10 times the amount, boil, keep on low heat for 1 hour, and extract again.

[0049] Combine the medicinal liquid: Combine the two extracted medicinal liquids, filter to remove the medicinal residue, and collect the clear liquid for later use. Concentrate the extracted medicinal liquid into a thick paste. Use a vacuum concentrator to concentrate below 60°C to avoid the decomposition of the active ingredients due to high temperature. Concentrate until the medicinal liquid has a specific gravity of about 1.2 (20% heavier than water), or concentrate to a volume of about 1 / 5 of the weight of the original medicinal material, making it a thick paste.

[0050] The concentrated thick paste is placed in a spray dryer, the temperature is controlled at 80-90℃, and spray dried to obtain Chinese medicine powder after drying. The dried powder must ensure that the water content is less than 5% to prevent the capsule from deteriorating during long-term storage. Menthol is a volatile component and cannot be extracted by high temperature. Menthol can be added to the dried powder, or menthol can be dissolved in ethanol and then fully mixed with the powder to make it evenly distributed in the powder. After the menthol is dissolved, it is sprayed on the dry powder and mixed evenly. After completion, it is sealed and stored to prevent volatilization. All prepared powders (including powders with menthol added) are mixed evenly. A mixer can be used to ensure that the components are evenly distributed. The mixing time is about 20-30 minutes. After the mixing is completed, the uniformity of the powder is sampled and checked to ensure that the components of each batch are uniform. Select a suitable size 0 hollow capsule and fill the evenly mixed powder into the capsule shell. The amount of capsule filling needs to be precisely controlled, and an automatic capsule filling machine can be used to ensure that the drug dosage of each capsule is consistent. The weight of each capsule can be designed as needed, and each capsule is filled with about 0.3g to 0.5g of drug powder, and finally compound Chuanbei loquat capsules AE are obtained respectively.

[0051] Example 7 Experiment on the use of Compound Chuanbei Loquat Capsule AF in the treatment of cold cough model mice

[0052] The weight of adult male BALB / c mice is usually between 20 and 30 grams. Adult male BALB / c mice weighing about 20 grams were selected and divided into a group of 20 adult male BALB / c mice. The experimental grouping treatment is as follows:

[0053] Blank control group: No cold stimulation and cough induction were performed, normal living conditions were maintained, and feeding was carried out for 28 days.

[0054] Model group: The rats were subjected to cold stimulation and ammonia cough induction, and the cough response was observed. At the same time, an equal amount of normal saline was gavage-fed for 28 consecutive days.

[0055] Capsule A group: cold stimulation and cough induction were performed, and Compound Chuanbei Loquat Capsule A was given at the same time. Each mouse weighing approximately 20g should take a total of about 45mg of Compound Chuanbei Loquat Capsule A per day. The drug was fed continuously for 28 days to observe the therapeutic effect of the drug.

[0056] Capsule Group B: Cold stimulation and cough induction were performed, and Compound Chuanbei Loquat Capsule B was given at the same time. Each mouse weighing approximately 20g should take a total of about 45mg of Compound Chuanbei Loquat Capsule B per day. The drug was fed continuously for 28 days to observe the therapeutic effect of the drug.

[0057] Capsule C group: The mice were subjected to cold stimulation and cough induction, and were given Compound Chuanbei Loquat Capsule C at the same time. Each mouse weighed approximately 20 g, and the total amount of Compound Chuanbei Loquat Capsule C to be taken per day was approximately 45 mg. The drug was fed continuously for 28 days to observe the therapeutic effect of the drug.

[0058] Capsule D group: cold stimulation and cough induction were performed, and Compound Chuanbei Loquat Capsule D was given at the same time. Each mouse weighing approximately 20g should take a total of about 45mg of Compound Chuanbei Loquat Capsule D per day. The drug was fed continuously for 28 days to observe the therapeutic effect of the drug.

[0059] Capsule E group: The mice were subjected to cold stimulation and cough induction, and were given Compound Chuanbei Loquat Capsule E at the same time. Each mouse weighed approximately 20 g, and the total amount of Compound Chuanbei Loquat Capsule E to be taken per day was approximately 45 mg. The drug was fed continuously for 28 days to observe the therapeutic effect of the drug.

[0060] Capsule F group: The mice were subjected to cold stimulation and cough induction, and were given Compound Chuanbei Loquat Capsule F at the same time. Each mouse weighing approximately 20 g should take a total of approximately 45 mg of Compound Chuanbei Loquat Capsule E per day. The drug was fed continuously for 28 days to observe the therapeutic effect of the drug.

[0061] Positive control group: cold stimulation and cough induction were performed, and the positive control drug ambroxol was used for treatment. Each mouse weighing approximately 20g should take 0.09mg of ambroxol per day, and the drug was fed continuously for 28 days to observe the therapeutic effect of the drug.

[0062] Cold water swimming method for cold stimulation:

[0063] Place adult male BALB / c mice in 4°C cold water and let them swim for 5 minutes. This step is used to simulate the cold response of mice after cold exposure. Cold stimulation can cause cold cough symptoms in the mouse immune system and respiratory tract. After taking them out, quickly dry their hair and put them back in the normal breeding environment to prevent infection.

[0064] Ammonia stimulation method for cough induction:

[0065] Place the BALB / c mice after cold stimulation in a closed stimulation box, and use a nebulizer to spray 0.25%-0.3% ammonia water into the box through a nebulizer, so that the mice can inhale it. Each spray of ammonia water lasts for 30 seconds. Each mouse is exposed to ammonia water, and its coughing reaction is observed and recorded. Usually the coughing reaction occurs within 2-3 minutes and lasts for about 10 minutes. Observe and record the mouse's coughing latency and the number of coughs within 2 minutes.

[0066] Effects of Fufang Chuanbei Loquat Capsule on the body weight of mice induced by cold stimulation and cough. The changes in body weight of mice at the end of the experimental group were recorded, as shown in Table 1.

[0067] Table 1 Effect of Fufang Chuanbei Loquat Capsule on the body weight of mice induced by cold stimulation and cough (mean ± SD, n = 20)

[0068] Group Final body weight / g Blank control group 23.25±1.62 Model Group <![CDATA[13.37±1.37 a ]]> Capsule Group A <![CDATA[21.67±1.05 c ]]> Capsule Group B <![CDATA[22.55±1.26 d ]]> Capsule C group <![CDATA[23.56±1.72 d ]]> Capsule D group <![CDATA[21.42±1.24 c ]]> Capsule Group E <![CDATA[22.34±1.21 c ]]> Capsule F Group <![CDATA[18.45±1.92 d ]]> Positive control group <![CDATA[17.82±1.28 d ]]>

[0069] Note: Compared with the blank control group, a P<0.05, b P<0.01; compared with the model group, c P<0.05, d P<0.01.

[0070] The results in Table 1 show that compared with the blank control group, the body weight growth rate of mice in the model group was significantly reduced (P < 0.05); compared with the model group, the body weight growth rate of mice in capsule AF groups was significantly increased (P < 0.05 or P < 0.01), and the effect of capsule AE group on improving the body weight growth rate of mice was significantly better than that of capsule F group, which indicates that the compound Chuanbei loquat capsule of the present invention has the effect of significantly improving the body weight of the mouse model induced by cold stimulation and cough.

[0071] The effects of Fufang Chuanbei Loquat Capsule on the cough latency and the number of coughs within 2 minutes in mice induced by cold stimulation and cough are shown in Table 2.

[0072] Table 2 Effects of Fufang Chuanbei Loquat Capsule on the cough latency and cough frequency of mice with cold cough (mean ± SD, n = 20)

[0073] Group Cough latency period / s Number of coughs Model Group 19.25±2.73 59.32±4.81 Capsule Group A <![CDATA[32.39±3.26 c ]]> <![CDATA[34.39±4.25 d ]]> Capsule Group B <![CDATA[33.49±3.28 c ]]> <![CDATA[32.19±3.95 d ]]> Capsule C group <![CDATA[32.15±4.46 d ]]> <![CDATA[35.68±3.22 c ]]> Capsule D group <![CDATA[31.42±3.74 c ]]> <![CDATA[30.43±4.47 c ]]> Capsule Group E <![CDATA[34.52±3.39 c ]]> <![CDATA[29.45±3.76 d ]]> Capsule F Group <![CDATA[27.41±4.81 c ]]> <![CDATA[38.54±5.86 d <!-- 5 -->]]> Positive control group <![CDATA[28.29±2.95 d ]]> <![CDATA[41.56±3.43 c ]]>

[0074] Note: Compared with the model group, c P<0.05, d P<0.01.

[0075] The results in Table 2 show that compared with the model group, the cough latency of mice in capsule AF group was significantly prolonged (P < 0.05 or P < 0.01); the number of coughs of mice in each medication group was significantly reduced compared with the model group (P < 0.05 or P < 0.01), and the capsule AE group was significantly superior to the capsule F group and the positive control group in prolonging the cough latency of mice with cold cough and reducing the number of coughs of mice. That is, the compound Chuanbei loquat capsule AE of the present invention significantly prolongs the cough latency of mice with cold cough, reduces the number of coughs of mice, and has a significant antitussive effect.

[0076] Construction of tracheal phenol red secretion model in cold cough mice: The mice in the successfully constructed model group, capsule AF group and positive control group were given drugs according to the requirements of each group for 28 consecutive days. One hour after the last drug administration, the mice were intraperitoneally injected with 20 mL / kg of 5% phenol red saline solution. After 30 minutes, the trachea was removed and placed in 4 mL of saline, and 0.2 mL of 5% sodium bicarbonate solution was added. The phenol red in the trachea was completely released by shaking. The OD value was measured at 546 nm, and the excretion of phenol red was calculated according to the standard curve of phenol red, as shown in Table 3.

[0077] Table 3 Effect of Fufang Chuanbei Pipa Capsule on tracheal phenol red secretion in mice with cold cough (mean ± SD, n = 20)

[0078] Group Phenol red secretion / (ng / mL) Model Group 1.63±0.48 Capsule Group A <![CDATA[4.58±0.52 c ]]> Capsule Group B <![CDATA[4.34±0.39 c ]]> Capsule C group <![CDATA[4.37±0.58 d ]]>

Claims

1. A compound Chuanbei loquat capsule is prepared from the following raw materials by weight: loquat leaf 10-12g, cinnamon twig 9-10g, Codonopsis pilosula 10-12g, Platycodon 5-6g, Fritillaria 5-6g, Pinellia 5-6g, Tangerine peel 5-6g, dried ginger 2-3g, and menthol 0.5-1g.

2. The compound Chuanbei loquat capsule according to claim 1, characterized in that: The compound Chuanbei loquat capsule is prepared from the following raw materials by weight: 12g loquat leaf, 10g cassia twig, 12g Codonopsis pilosula, 5g Platycodon grandiflorum, 6g Fritillaria cirrhosa, 6g Pinellia tuber, 5g dried tangerine peel, 2g dried ginger, and 0.5g menthol.

3. The compound Chuanbei loquat capsule according to claim 1, characterized in that: The compound Chuanbei loquat capsule is prepared from the following raw materials by weight: loquat leaf 10g, cassia twig 10g, Codonopsis pilosula 10g, Platycodon grandiflorum 6g, Fritillaria 5g, Pinellia 5g, Tangerine peel 6g, dried ginger 2g, and menthol 1g.

4. The compound Chuanbei loquat capsule according to claim 1, characterized in that: The compound Chuanbei loquat capsule is prepared from the following raw materials by weight: 12g loquat leaf, 9g cassia twig, 12g Codonopsis pilosula, 6g Platycodon grandiflorum, 5g Fritillaria cirrhosa, 6g Pinellia tuber, 6g dried orange peel, 3g dried ginger and 1g menthol.

5. The compound Chuanbei loquat capsule according to claim 1, characterized in that: The compound Chuanbei loquat capsule is prepared from the following raw materials by weight: 12g loquat leaf, 10g cassia twig, 10g codonopsis pilosula, 5g platycodon, 6g citronella, 6g pinellia tuber, 6g tangerine peel, 2g dried ginger, and 0.5g menthol.

6. The compound Chuanbei loquat capsule according to claim 1, characterized in that: The compound Chuanbei loquat capsule is prepared from the following raw materials by weight: 12g loquat leaf, 10g cassia twig, 12g Codonopsis pilosula, 5g Platycodon grandiflorum, 6g Fritillaria cirrhosa, 6g Pinellia tuber, 6g Tangerine peel, 2g Dry ginger, and 0.5g menthol.

7. Use of the compound Chuanbei loquat capsule according to any one of claims 1 to 6 in the preparation of a medicine for treating cough.