Microsphere for injuecting 'Shuang Hualian' for treating viral disease of bird and preparation thereof

A viral disease, Shuanghuanglian technology, applied in the field of Shuanghuanglian injection microspheres for the treatment of poultry viral diseases and its preparation, can solve the problems of unsatisfactory treatment effect, poor absorption effect, inconvenient use, etc., and achieve enhanced body fluid Effects of immunity and cellular immunity, promotion of recovery of feed intake, improvement of compliance

Inactive Publication Date: 2009-01-21
TIANJIN SHENGJI GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] If Chinese medicinal raw materials are used to make tablets, powders, etc., due to the short half-life of water-soluble active ingredients in some Chinese medicinal materials, frequent administration is required, so it is inconvenient to use; at the same time, the absorption effect is not good, and the therapeutic effect is not ideal.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take 247g of Coptis chinensis, 267g of honeysuckle, 263g of forsythia, and 223g of astragalus, decoct the crushed honeysuckle and forsythia in water twice, add 7 times the amount of water each time, for 2 hours each time, combine the decoction liquid, filter, Concentrate the filtrate to 900ml, add 95% ethanol to make the alcohol concentration reach 70%, let it stand for 12 to 24 hours, filter, and recover ethanol; continue to concentrate into honeysuckle forsythia extract; decoct the crushed Astragalus membranaceus with water twice , add 6 times the amount of water each time, extract in turn for 2 hours and 1 hour, combine the filtrate, and when concentrated to about 1500ml, add 95% ethanol to make the alcohol concentration 60%, let it stand for 12-24 hours, filter, and recover ethanol from the filtrate , when concentrated to about 400ml, add 95% ethanol to make the alcohol concentration 80%, let it stand for 12-24 hours, filter, recover ethanol from the filtrate, and co...

Embodiment 2

[0038] Take 149g of Coptis chinensis, 422g of honeysuckle, 264g of forsythia, 165g of astragalus, decoct the crushed honeysuckle and forsythia in water twice, add 7 times the amount of water each time, each time for 2 hours, combine the decoction liquid, filter, Concentrate the filtrate to 900ml, add 95% ethanol to make the alcohol concentration reach 70%, let it stand for 12 to 24 hours, filter, and recover ethanol; continue to concentrate into honeysuckle forsythia extract; decoct the crushed Astragalus membranaceus with water twice , add 6 times the amount of water each time, extract in turn for 2 hours and 1 hour, combine the filtrate, and when concentrated to about 1500ml, add 95% ethanol to make the alcohol concentration 60%, let it stand for 12-24 hours, filter, and recover ethanol from the filtrate , when concentrated to about 400ml, add 95% ethanol to make the alcohol concentration 80%, let it stand for 12-24 hours, filter, recover ethanol from the filtrate, and contin...

Embodiment 3

[0042] Take 331g of Coptis chinensis, 165g of honeysuckle, 312g of forsythia, and 192g of astragalus, decoct the crushed honeysuckle and forsythia in water twice, add 7 times the amount of water each time, for 2 hours each time, combine the decoction liquid, filter, Concentrate the filtrate to 900ml, add 95% ethanol to make the alcohol concentration reach 70%, let it stand for 12 to 24 hours, filter, and recover ethanol; continue to concentrate into honeysuckle forsythia extract; decoct the crushed Astragalus membranaceus with water twice , add 6 times the amount of water each time, extract in turn for 2 hours and 1 hour, combine the filtrate, and when concentrated to about 1500ml, add 95% ethanol to make the alcohol concentration 60%, let it stand for 12-24 hours, filter, and recover ethanol from the filtrate , when concentrated to about 400ml, add 95% ethanol to make the alcohol concentration 80%, let it stand for 12-24 hours, filter, recover ethanol from the filtrate, and co...

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Abstract

The invention relates to a microsphere used for injecting Shuanghuanglian which is used for treating poultry viral diseases and a preparation method thereof; the microsphere consists of 2-60% of Chinese medicinal material extracts which are taken as active ingredients and 39-95% of biodegradable medicinal high-molecular excipients which have microsphere weight and have molecular weight ranging from 4,000 to 9,000,000 by weight proportion; wherein, the weight percentage of medicinal materials is as follows: 13-40% of Chinese goldthread, 15-45% of honeysuckle, 25-61% of forsythia and 11-40% of milk veteh. The medicines are prepared into microspheres by emulsifying dispersion method. The beneficial effects of the invention is that: (1) developing a new medicine preparation for preventing and treating poultry viral diseases and increasing disease resistance of the body; (2) reasonable prescription and strong antiviral ability; (3) advanced technique, stable preparation and long storage time; (4) broad medicine sources and no toxicity and side effect, little drug resistance generated and meeting the international sanitary inspection requirements. Especially, the microsphere has significant effect on the treatment of poultry infectious bursal disease, untypical Newcastle disease, infective bronchitis, etc.

Description

technical field [0001] The invention relates to the field of medicine for treating animal diseases, in particular to Shuanghuanglian injection microspheres for treating poultry viral diseases and a preparation method thereof. Background technique [0002] At present, in the treatment of poultry viral diseases, antibiotics are usually the main treatment, which not only has relatively large toxic and side effects, such as certain side effects on the liver and kidney functions of poultry, which will easily cause drug residues in the poultry body; it will also pollute the environment, and the treatment The cost is higher. [0003] Astragalus is the dried root of the leguminous plant Astragalus mongolica or Astragalus membranaceus. Its main ingredients are oatmeal, polysaccharides, amino acids and trace elements. It has the effects of enhancing the body's immunity, diuresis, anti-aging, protecting the liver, lowering blood pressure, strengthening the heart, dilating coronary bl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61K9/16A61K47/34A61P31/12A61K47/10
Inventor 田杏芳王连民
Owner TIANJIN SHENGJI GRP CO LTD
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