Method for measuring content of chemical components in traditional Chinese medicine compound preparation

Abstract

The invention provides a method for determining the content of chemical components in a traditional Chinese medicine compound preparation, belongs to the technical field of Chinese patent medicine content determination, and aims to detect the components with greatly different contents in traditional Chinese medicines, accurately determine the contents of high-content components and low-content components in the same traditional Chinese medicine sample and judge the mass change of the traditional Chinese medicines. The traditional Chinese medicine is Shuanghuanglian injection. In order to solve the problem of simultaneous determination of components with great content differences in a traditional Chinese medicine complex system, a multiple dilution method is constructed, a test solution with a low dilution ratio is prepared to detect low-content components (21 components such as neochlorogenic acid), and a test solution with a high dilution ratio is prepared to detect high-content components (baicalin). Rapid detection of components with great content differences in the sample is realized through different dilution methods. The dilution ratio and dilution times of the test solution can be determined according to the content difference degree of the detection components in the to-be-detected sample. The method effectively solves the problem of detection of the components with the content difference.

Description

technical field [0001] The invention relates to the technical field of content determination of Chinese patent medicines, in particular to a method for determining the content of chemical components in compound Chinese medicine preparations. Background technique [0002] Chinese patent medicine and its decoction pieces are a complex system composed of multiple components, and there are often situations where the content of chemical components is very different. The determination of the content of a single component or a component with a high content cannot fully reflect its quality change. Therefore, it is necessary to develop a simple, It is particularly important to have an effective method for the determination of components with disparity in content in samples. [0003] Shuanghuanglian injection is a water injection prepared from honeysuckle, forsythia, and scutellaria baicalensis through a series of modern pharmaceutical processes. It is suitable for upper respiratory ...

AI Technical Summary

Problems solved by technology

The invention aims to solve the problems of the existing method for determining the content of Shuanghuanglian for injection, the sample processing is complicated, the detection of Shuanghuanglian is time-consuming, a large number of personnel and inspection equipment are occupied, and the inspection period is long.

The invention provides a simultaneous determination of forsythin, forsythiaside A, caffeic acid, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isochlorogenic acid A, isochlorogenic acid C, The content of more than 10 components such as baicalin, baicalein, and kelp-7-O-glucuronide, the detection is not comprehensive enough

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