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'Shuang Huang Lian' dispersible tablet and preparation method thereof

A technology of dispersible tablets and Shuanghuanglian, which is applied in the field of Shuanghuanglian dispersible tablets, can solve the problems of low bioavailability of human body, backward preparation technology, large dosage, etc., achieve the onset time of body temperature drop and antipyretic time, and meet medical needs , Ease of use

Inactive Publication Date: 2006-12-20
NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Shuanghuanglian preparation is a pure traditional Chinese medicine preparation. Its main ingredients are honeysuckle, forsythia, and skullcap. It has the effect of clearing away heat and detoxifying. , oral liquid, aerosol, tablet, etc., have obtained the approval number, but the above-mentioned dosage forms still have some deficiencies, such as the disadvantage of poor stability in water injections; powder injections have high technical requirements and long production cycles. Quite difficult; these two injections are prone to infusion reactions, so their use is limited
[0004] Due to technical limitations and the lack of various quality control standards, the traditional Shuanghuanglian preparation has seriously inhibited its wider use and larger market share, and it cannot enter the international pharmaceutical market.
The main problems are: the extraction process is rough and the dosage is large; the fat-soluble antiviral active ingredients in the prescription cannot be effectively captured in the traditional process, which affects the efficacy of the drug; long time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0207] Example 1 Preparation of Extract from Shuanghuanglian Dispersible Tablets

[0208] Prescription: Honeysuckle 1875g

[0209] Forsythia 3750g

[0210] Scutellaria baicalensis 1875g

[0211] Preparation:

[0212] The above three flavors, Scutellaria baicalensis slices, add 80 ° C water decoction three times for 2 hours for the first time, the second and third times for 1 hour each, combine the decoction, filter, and the filtrate is concentrated to a clear liquid with a relative density of 1.03 (measured at 80 ° C). Paste, adjust pH to 1.0 with hydrochloric acid (2mol / L) at 80°C, keep warm for 1 hour, let stand for 24 hours, filter, wash the precipitate with water to pH 5.0, then wash with 70% ethanol to pH 7.0, spray dry , to obtain Scutellaria baicalensis extract. Mix honeysuckle and forsythia, pulverize into coarse powder, carry out supercritical carbon dioxide extraction under the condition of pressure 8.0Mpa, temperature 32 ℃, extraction time is 1 hour,...

Embodiment 2

[0213] Example 2 Preparation of Extract from Shuanghuanglian Dispersible Tablets

[0214] Prescription: Honeysuckle 750g

[0215] Forsythia 2250g

[0216] Scutellaria baicalensis 4500g

[0217] Preparation:

[0218] The above three flavors, Scutellaria baicalensis slices, add 80 ° C water decoction three times for 2 hours for the first time, the second and third times for 1 hour each, combine the decoction, filter, and concentrate the filtrate to a clear liquid with a relative density of 1.08 (measured at 80 ° C). Paste, adjust the pH value to 2.0 with hydrochloric acid (2mol / L) at 80°C, keep it warm for 1 hour, let stand for 24 hours, filter, wash the precipitate with water until the pH is 5.0, then wash with 70% ethanol until the pH is 7.0, spray Dried to obtain the Scutellaria baicalensis extract. Mix honeysuckle and forsythia, pulverize into coarse powder, carry out supercritical carbon dioxide extraction under the condition of pressure of 14.0Mpa and tempe...

Embodiment 3

[0219] Example 3 Preparation of Extract from Coptis Rhizoma Dispersible Tablets

[0220] Prescription: Honeysuckle 750g

[0221] Forsythia 6000g

[0222] Scutellaria baicalensis 750g

[0223] Preparation:

[0224] The above three flavors, Scutellaria baicalensis slices, add 80 ℃ water decoction three times for 2 hours for the first time, the second and third times for 1 hour each, combine the decoction, filter, and concentrate the filtrate to a clear liquid with a relative density of 1.05 (measured at 80 ℃). paste, adjust the pH value to 1.5 with hydrochloric acid (2mol / L) at 80°C, keep it warm for 1 hour, let it stand for 24 hours, filter, wash the precipitate with water until the pH is 5.0, then wash with 70% ethanol until the pH is 7.0, and spray Dried to obtain the Scutellaria baicalensis extract. Mix honeysuckle and forsythia, pulverize into coarse powder, carry out supercritical carbon dioxide extraction under the conditions of pressure 12.0Mpa and temper...

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PUM

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Abstract

The invention discloses a Shuanghuanglian dispersible tablet prepared from honeysuckle flower, capsule of weeping forsythia, baikal skullcap root glycosides and medicinal auxiliary materials including crumbling agent, bulking agent and lubricating agent. The invention also discloses the process for preparing the tablet through pelletization with fluidized bed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a Shuanghuanglian dispersible tablet; in addition, the invention also relates to a preparation method of the Shuanghuanglian dispersible tablet. Background technique [0002] Shuanghuanglian preparation is a pure traditional Chinese medicine preparation. Its main ingredients are honeysuckle, forsythia, and skullcap. It has the effect of clearing away heat and detoxifying. , oral liquid, aerosol, tablet, etc., have obtained the approval number, but the above-mentioned dosage forms still have some deficiencies, such as the disadvantage of poor stability in water injections; powder injections have high technical requirements and long production cycles. It is quite difficult; these two injections are prone to infusion reactions, so their use is limited. In addition to instability, oral liquid also has disadvantages such as high cost and inconvenient portability. Granule...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61K9/20A61P11/04
Inventor 刘志远阮克锋沈平孃陈鼎和刘峻唐英齐春华唐华
Owner NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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