Method for refining Shuanghuanglian preparation by using membrane separation technology

A separation technology, the technology of Shuanghuanglian, is applied in the field of refining and separation of Shuanghuanglian extract to achieve the effect of improving the efficacy and medicinal power.

Inactive Publication Date: 2018-06-01
SHIJIAZHUANG WEIERLI ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, all dosage forms are based on the water extract of Shuanghuanglian without further refining treatment, and there is still a high room for improvement in its efficacy and potency

Method used

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  • Method for refining Shuanghuanglian preparation by using membrane separation technology
  • Method for refining Shuanghuanglian preparation by using membrane separation technology
  • Method for refining Shuanghuanglian preparation by using membrane separation technology

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Experimental program
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Effect test

Embodiment 1

[0021] Embodiment 1, the optimum implementation mode of refining method.

[0022] A method for refining Shuanghuanglian preparations using membrane separation technology, comprising the steps of:

[0023] A. Preparation of water extract: Weigh honeysuckle and forsythia according to the prescription amount, add 10 times the amount of water by weight, soak at 35°C for 0.5h, decoct twice for 1.5h each time, and combine the filtrate after filtration; Methods Scutellaria baicalensis was extracted with water, and the filtrate was combined for later use;

[0024] B. Ceramic membrane refining: take the water extract obtained in step A, add it to the ceramic membrane equipment feeding cylinder, start the machine for continuous filtration, regularly check and adjust the parameters of membrane flux and liquid inlet pressure, and collect the filtrate; the filtration of the ceramic membrane equipment The pore diameter of the membrane is 450nm; when the ceramic membrane equipment is starte...

Embodiment 2

[0028] Example 2. Effects of different membrane pore sizes on membrane flux and retention performance.

[0029] The aqueous extract of Shuanghuanglian effervescent tablets was treated by ceramic membranes with pore diameters of 50, 100, 200, 450, and 800 nm at a temperature of 25 ° C and an inlet pressure of 0.15 to 0.22 MPa to investigate the membrane flux of ceramic membranes with different pore sizes and solids removal rate, the results are shown in Table 2.

[0030] Table 2 Comparison of permeability performance and solids removal rate of different membrane pore sizes

[0031]

[0032] Solids removal rate = (total solids in the original drug solution - total solids in the filtrate) / total solids in the original drug solution.

Embodiment 3

[0033] Example 3. Effects of different membrane pore sizes on the properties of the water extract and the amount of active ingredients.

[0034] The properties of the medicinal liquid before and after filtration with different membrane pore sizes were compared, the amount of paeoniflorin in the medicinal liquid before and after filtration was measured, and the transfer rate of paeoniflorin was calculated. The results are shown in Table 3. After the water extract of Shuanghuanglian effervescent tablets was filtered through 5 kinds of ceramic membranes with different pore sizes, the medicinal liquid obtained after filtration through 800nm ​​ceramic membranes was slightly turbid, and the filtrates obtained by filtration through the other four pore sizes of ceramic membranes were obviously transparent and clear compared with those before filtration, showing The clarification effect of ceramic membrane filtration on the water extract is obvious. The transfer rate of chlorogenic ac...

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Abstract

The invention discloses a method for refining a Shuanghuanglian preparation by using a membrane separation technology. The method comprises the following steps: A. preparing water extract: weighing honeysuckle flower, radix scutellariae and fructus forsythiae according to a prescription, and carrying out water extraction on the weighed materials for later use; B. refining by a ceramic membrane: adding the water extract into a ceramic membrane device for continuously filtering, and collecting filtrate, wherein the pore sizes of a filtration membrane of the ceramic membrane device are 400-500nm;C. directly using the filtrate obtained in the step B as liquid medicine to leave factory, or taking the filtrate as a raw material to prepare extract, tablet, powder, granules, injection and suppository. The treatment method provided by the invention enables the efficacy of the original Shuanghuanglian water extract to be effectively improved; in particular, the 450nm film determined by means ofseries of research and development has the best comparative advantages and practical effects in terms of parameters such as extract yield, chlorogenic acid content, baicalin content, forsythin content, membrane flux and interception performance.

Description

technical field [0001] The invention relates to the extraction technology of active ingredients of Chinese patent medicines, in particular to the refining and separation technology and method of Shuanghuanglian extract. Background technique [0002] The traditional Chinese medicine Shuanghuanglian preparation is composed of honeysuckle, scutellaria baicalensis and forsythia. It is very popular with patients and has a large market sales volume. According to modern pharmacological research and animal experiments, Shuanghuanglian has excellent antibacterial effect, and has a certain inhibitory effect on Staphylococcus aureus, hemolytic streptococcus, pneumococcus, Shigella, etc. At present, its preparations include Shuanghuanglian oral liquid, Shuanghuanglian tablets, Shuanghuanglian freeze-dried powder, Shuanghuanglian injection, Shuanghuanglian granules, Shuanghuanglian buccal tablets, Shuanghuanglian effervescent tablets, Shuanghuanglian suppositories, etc. However, all do...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61P11/00A61P11/04A61P31/04G01N5/04G01N30/02
CPCA61K36/355A61K36/539A61K36/634A61K2236/331A61K2236/39A61K2236/53G01N5/04G01N30/02A61K2300/00
Inventor 陆安杜红娜张俊秀左广双李华声郭宽郭永红
Owner SHIJIAZHUANG WEIERLI ANIMAL PHARMA
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