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Shuanghuanglian in situ gel preparation and preparation method thereof

An in-situ gel, Shuanghuanglian technology, applied in the directions of anti-inflammatory agents, pharmaceutical formulations, antiviral agents, etc., can solve the problems of low bioavailability, and achieve the effects of high bioavailability, rapid onset of action, and stable properties.

Inactive Publication Date: 2010-05-12
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the shortcomings of Shuanghuanglian, such as serious adverse reactions of injection administration or low bioavailability of oral administration, to provide a kind of medicine with definite curative effect, stable quality, simple preparation, convenient use, strong patient compliance and non-toxicity. Side effects and adverse reactions, a new dosage form of traditional Chinese medicine with high bioavailability-Shuanghuanglian in situ gel and its preparation method

Method used

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  • Shuanghuanglian in situ gel preparation and preparation method thereof
  • Shuanghuanglian in situ gel preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation of Radix Scutellariae Extract

[0023] Prepare according to the method of "Chinese Pharmacopoeia" 2005 edition one: take Scutellaria baicalensis, add water to decoct, combine the decoction, concentrate to an appropriate amount, adjust the pH value to 1.0-2.0 with hydrochloric acid, keep warm at 80°C, stand still, filter, and precipitate Add an appropriate amount of water and stir well, adjust the pH value to 7.0 with 40% sodium hydroxide solution, add an equal amount of ethanol, stir to dissolve, filter, adjust the pH value of the filtrate to 1.0-2.0 with hydrochloric acid, keep warm at 60°C, stand still, filter After that, the precipitate was washed successively with appropriate amount of water and different concentrations of ethanol until the pH value reached 7.0, the ethanol was evaporated, and dried under reduced pressure to obtain the final product. This product is calculated as a dry product, containing baicalin (C 21 h 18 o 11) shall not be less th...

Embodiment 2

[0025] Preparation of Yinqiao Extract

[0026] Yinqiao extract is made according to the following method:

[0027] (a) Take the decoction pieces of honeysuckle and forsythia medicinal materials (weight ratio 1:2), decoct in water to extract, and filter the decoction;

[0028] (b) The filtrate is put on a macroporous adsorption resin chromatography column, first washed with water to remove impurities, then eluted with water-containing lower alcohol, and the eluate is collected;

[0029] (c) The eluate is concentrated under reduced pressure until it is free of alcohol, and dried into powder to obtain the extract of Yinqiao.

[0030] in:

[0031] In step (a), decoct 2 to 3 times with 8 to 12 times the amount of water, each time for 40 to 60 minutes.

[0032] In step (b), macroporous adsorption resin is styrene type (preferred model is NKA-II); The carbon atom scope of lower alcohol is C 1 ~C 5 , such as methanol, ethanol, etc., the elution concentration is 50% to 70% (the be...

Embodiment 3

[0036] Preparation of Yinqiao Extract

[0037] (a) Take an appropriate amount of decoction pieces of honeysuckle medicinal material, decoct in water to extract, and filter the decoction;

[0038] (b) The filtrate is put on a macroporous adsorption resin chromatography column, first washed with water to remove impurities, then eluted with water-containing lower alcohol, and the eluate is collected;

[0039] (c) Concentrate the eluate under reduced pressure until it is free of alcohol, and dry it into powder to obtain the honeysuckle extract.

[0040] (d) Take an appropriate amount of decoction pieces of forsythia medicinal material, decoct in water to extract, and filter the decoction;

[0041] (e) on the macroporous adsorption resin chromatography column on the filtrate, first wash with water to remove impurities, then elute with water-containing lower alcohol, and collect the eluate;

[0042] (f) Concentrate the eluent under reduced pressure until it is free of alcohol, and...

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Abstract

The invention belongs to the field of traditional Chinese medicine preparation, relating to a Shuanghuanglian in situ gel preparation and a preparation method thereof. The in situ gel preparation is prepared from water as solvent, Shuanghuanglian extract, in situ gel matrix accepted in the field and other necessary auxiliary materials in pharmacy and clarifies the preparation method. The invention is freely flowing liquid at room temperature, forms semi-solid gel after applying drug to rectum of patients and has the advantages of exact effect, stable performance, simple preparation, convenient drug administration, strong patient compliance, no toxic and side effect, no adverse reaction, high bioavailability and the like. The Shuanghuanglian in situ gel preparation has the efficacy of relieving the exterior syndrome with drugs pungent in flavor and cool in property, clearing away heat and toxic material and dispersing lung qi and wind heat and is used for treating fever caused by exogenous wind heat, cough, pharyngalgia, virus and bacterial infection upper respiratory tract infection, pulmonitis, tonsillitis, pharyngitis and the like.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine, and more specifically relates to a novel Shuanghuanglian in-situ gel preparation for rectal administration and a preparation method thereof. Background technique: [0002] In recent years, with the large-scale clinical application of traditional Chinese medicine injections, the problem of adverse reactions has become more and more prominent. Among them, the adverse reactions of traditional Chinese medicine Shuanghuanglian injections have been reported from time to time. How to solve the adverse reaction of Shuanghuanglian injection, a traditional Chinese medicine, has been a hot topic of debate in the academic circles in recent years, and it is also a key and difficult point for pharmaceutical workers to tackle key problems in scientific research. One of the solutions is to find a new dosage form of traditional Chinese medicine that can replace Shuanghuanglian injection, so that it ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61K9/00A61K47/38A61K47/34A61K47/32A61P29/00A61P11/04A61P11/00A61P31/04A61P31/12A61K47/10
Inventor 仝燕王锦玉陈两绵马振山王琳王智民
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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