Method for preparing a Shuanhuanglian injection and the component detecting method

A Shuanghuanglian injection and composition detection technology, which is applied to the separation of medical preparations containing active ingredients, plant/algae/fungus/moss components, materials, etc., can solve the problems of easy damage and low yield of honeysuckle

Active Publication Date: 2007-09-26
HARBIN ZHENBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the active ingredient of honeysuckle - chlorogenic acid is easily destroyed by high temperature, so honeysuckle and forsythia are used for co-extraction, and the yield of honeysuckle is low

Method used

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  • Method for preparing a Shuanhuanglian injection and the component detecting method
  • Method for preparing a Shuanhuanglian injection and the component detecting method
  • Method for preparing a Shuanhuanglian injection and the component detecting method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1 Shuanghuanglian injection preparation method

[0053] 1) Preparation of honeysuckle concentrated extract

[0054] Weigh honeysuckle, add 10 times the amount of water for the first time, soak at 80°C for 1 hour, add 10 times the amount of water for the second time, soak at 80°C for 40 minutes, filter in stages, collect the filtrate and concentrate to a relative density of 1.20± 0.02 (measured at 80±5°C), when the temperature drops below 40°C, add 90% ethanol to 75% alcohol content, let it stand for 12 hours, filter, and recover the ethanol from the filtrate until it has no ethanol smell, and concentrate to a relative density of 1.18 ( 80±5°C test); when cooled to below 40°C, add purified water 4 times the paste weight, stir gently, let stand for 12 hours, take the supernatant and filter, and the filtrate is concentrated to a relative density of 1.20±0.02 (80±0.02 5°C test); to be cooled to below 40°C, add 95% ethanol while stirring to make the alcohol conte...

Embodiment 2

[0062] 1) Preparation of honeysuckle concentrated extract

[0063] Weigh honeysuckle, add 4 times the amount of water for the first time, soak at 60°C for 80 minutes, add 8 times the amount of water for the second time, soak at 80°C for 60 minutes, add 12 times the amount of water for the third time, and soak at 85°C Soak in heat for 30 minutes, filter several times, collect the filtrate and concentrate to a relative density of 1.18-1.22 (measured at 80±5°C), when the temperature drops below 40°C, add 95% ethanol until the alcohol content is 80%, and let it stand for 18 hours. Filtrate, recover ethanol from the filtrate until there is no ethanol smell, and concentrate to a relative density of 1.15-1.20 (measured at 80±5°C); when cooled to below 40°C, add purified water 6 times the paste weight, gently stir, and let stand for 24 hours, take the supernatant and filter, and the filtrate is concentrated to a relative density of 1.18 to 1.22 (measured at 80±5°C); when cooled to bel...

Embodiment 3

[0071] 1) Preparation of honeysuckle concentrated extract

[0072] Weigh honeysuckle, add 6 times the amount of water for the first time, soak at 70°C for 1 hour, add 16 times the amount of water for the second time, soak at 85°C for 30 minutes, filter in stages, collect the filtrate and concentrate it to a relative density of 1.18~ 1.22 (measured at 80±5°C), when the temperature drops below 40°C, add 90% ethanol to 78% alcohol content, let it stand for 24 hours, filter, recover ethanol from the filtrate until it has no ethanol smell, and concentrate to a relative density of 1.15~ 1.20 (measured at 80±5°C); when cooled to below 40°C, add purified water twice the weight of the paste, stir gently, let stand for 20 hours, take the supernatant and filter, and concentrate the filtrate to a relative density of 1.18-1.22 ( 80±5℃); when cooled to below 40℃, add 95% ethanol while stirring to make the alcohol content reach 85%, let it stand for 24 hours, and adjust the pH value of the s...

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Abstract

The invention provides a method for preparing an injection, comprising that extracting respectively the scutellaria root, honeysuckle flower and capsule of weeping forsythia, then preparing the injection. The invention also provides a component check method of the injection, for improving the quality control level, assure the treatment effect, and support the product detection.

Description

technical field [0001] The invention relates to a preparation method of Shuanghuanglian injection and a component detection method thereof, belonging to the field of traditional Chinese medicine. Background technique [0002] Shuanghuanglian injection is contained in the eleventh volume of Chinese medicine prescription preparations of the Ministry of Health's drug standard (WS3-B-2104-96), and it is composed of three herbs: honeysuckle, scutellaria baicalensis and forsythia. For fever, cough and sore throat caused by exogenous wind-heat. It is suitable for upper respiratory tract infection, pneumonia, tonsillitis, pharyngitis, etc. caused by viral and bacterial infections. In the prescription, honeysuckle is sweet and cold, with loose fragrance, and it is good at clearing heat evil in the lung meridian. Minister drug. The three medicines are used to play a total of pungent and cool to relieve the exterior, heat-clearing and detoxifying merits. [0003] Patent document 99...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61P11/04G01N30/02
Inventor 方同华
Owner HARBIN ZHENBAO PHARMA
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