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Veterinary Shuanghuanglian oral liquid preparation processed by using probiotics and preparation method thereof

A technology of Shuanghuanglian oral liquid and Shuanghuanglian, which is applied in the direction of medical preparations containing active ingredients, antibacterial drugs, antiviral agents, etc., can solve the imbalance of bacteria in the digestive system of animals, the large difference in environment, and the influence of fermentation environment And other issues

Inactive Publication Date: 2015-01-21
任夕德
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the defect of this method is: the fermentation condition adopted is quite different from the environment of the animal's digestive system, and therefore, after the microorganisms contained in the EM original dew enter the animal's digestive system with the reagent, it will bring a negative impact on its own fermentation environment. influences
But these two kinds of methods are mainly carried out for the Chinese medicine preparation for veterinary use, and the Chinese medicine preparation wherein contains multiflavor Chinese herbal medicine, but, those skilled in the art should know, like above-mentioned two kinds of Chinese medicine preparations, cost is very high on the one hand, on the other hand On the one hand, when microorganisms are fermenting, in addition to producing some beneficial ingredients, they will also produce some ingredients that are not conducive to the digestive system of the animal itself. For example, cassia seeds mainly contain chrysophanol, emodin and other compounds, and long-term consumption can cause intestinal lesions; At the same time, the above two methods use first-class microbial strains to ferment Chinese herbal medicines and then directly feed animals. The first-class microbial strains are extremely destructive to the colony of the animal's digestive system itself, which can easily lead to the destruction of the animal's own digestive system flora. out of balance

Method used

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  • Veterinary Shuanghuanglian oral liquid preparation processed by using probiotics and preparation method thereof
  • Veterinary Shuanghuanglian oral liquid preparation processed by using probiotics and preparation method thereof
  • Veterinary Shuanghuanglian oral liquid preparation processed by using probiotics and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0062] The preparation method of the above-mentioned veterinary Shuanghuanglian oral liquid preparation comprises the following steps:

[0063] (1) Shuanghuanglian traditional Chinese medicine powder preparation: Scutellaria baicalensis, honeysuckle, and forsythia were mixed evenly in a weight ratio of 1:2:4, and pulverized through a 40-mesh sieve;

[0064] (2) Preparation of primary strains of Lactobacillus acidophilus: put Lactobacillus acidophilus liquid culture medium into a container, sterilize at 120°C and 7.84MPa for 15min, cool to 35°C and inoculate and screen under aseptic conditions Lactobacillus acidophilus test-tube strains were cultured on a shaker at 35°C and 100r / min for 45 hours to obtain the first-grade Lactobacillus acidophilus strains;

[0065](3) Preparation of primary strains of Candida utilis: put liquid culture medium of Candida utilis into a container, sterilize at 120°C and 7.84MPa for 15min, cool to 25°C and then under aseptic conditions Inoculate th...

Embodiment 2

[0072] The preparation method of veterinary Shuanghuanglian oral liquid preparation, the detailed steps are as follows:

[0073] (1) Preparation of Shuanghuanglian traditional Chinese medicine powder: Scutellaria baicalensis, honeysuckle, and forsythia were mixed uniformly in a weight ratio of 1:1:2, and pulverized through a 60-mesh sieve;

[0074] (2) Lactobacillus acidophilus liquid culture medium: Shuanghuanglian traditional Chinese medicine powder 10g / L, diammonium citrate 2g / L, dipotassium hydrogen phosphate 2g / L, Tween802g / L, sodium acetate trihydrate 5g / L;

[0075] (3) Preparation of Lactobacillus acidophilus primary strain: 300ml of Lactobacillus acidophilus liquid strain culture medium was loaded into a 500ml triangular flask, sterilized at 121°C and 8.0MPa for 20min; cooled to 40°C, inoculated, screened and preserved under aseptic conditions Test-tube strains of Lactobacillus acidophilus, cultivated on a shaking table at 40°C and 110r / min for 48 hours, to obtain the ...

Embodiment 3

[0083] The preparation method of Shuanghuanglian oral liquid preparation for animals comprises the following steps:

[0084] (1) Shuanghuanglian traditional Chinese medicine powder preparation: Scutellaria baicalensis, honeysuckle, and forsythia were mixed evenly in a weight ratio of 2:1:3, and pulverized through an 80-mesh sieve;

[0085] (2) Preparation of primary strains of Lactobacillus acidophilus: put Lactobacillus acidophilus liquid culture medium into a container, sterilize at 125°C and 8.8MPa for 25min, cool to 45°C and inoculate and screen under aseptic conditions Lactobacillus acidophilus test-tube strains were cultivated in a shaker at 45°C and 120r / min for 52 hours to obtain the first-class strains of Lactobacillus acidophilus;

[0086] (3) Preparation of primary strains of Candida utilis: put liquid culture medium of Candida utilis into a container, sterilize at 125°C and 8.8MPa for 25min, cool to 35°C and then under aseptic conditions Inoculate the screened str...

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Abstract

The invention discloses a veterinary Shuanghuanglian oral liquid preparation processed by using probiotics. Secondary strains of functional microbes are inoculated to fermentation liquid of a Shuanghuanglian formula, and deep high-density fermentation of liquid is performed at normal temperature under normal pressure by using the life action of the functional microbes to sufficiently and effectively dissolve and convert active ingredients in the Shuanghuanglian formula, thus obtaining the Shuanghuanglian oral liquid biological preparation. The invention also provides a preparation method of the veterinary Shuanghuanglian oral liquid preparation at the same time. The Shuanghuanglian formula is screened as a Chinese medicinal formula, and the antibacterial, antivirus and heat clearing active ingredients included in the Shuanghuanglian formula are furthest extracted by using the functional microbes including lactobacillus acidophilus and candida utilis, so that the curative effect is enhanced. Meanwhile, the lactobacillus acidophilus and the candida utilis can play a role in maintaining and regulating the balance of gastrointestinal microbiota of animals.

Description

technical field [0001] The invention relates to a veterinary traditional Chinese medicine preparation, in particular to a veterinary Shuanghuanglian oral liquid preparation prepared by using probiotics, and also relates to a preparation method. Background technique [0002] Chinese herbal feed additives refer to some natural Chinese herbal medicines that are added to the feed according to the traditional Chinese medicine theory of our country, which have the functions of nourishing qi and invigorating the spleen, eliminating food and appetizing, nourishing qi and nourishing blood. It can promote the growth and development of animals, improve production performance, enhance the immune function of the body, improve the ability of animals to resist stress and disease, and has no residue, is not easy to produce drug resistance and side effects. [0003] Shuanghuanglian is a pure traditional Chinese medicine preparation. It is composed of three traditional Chinese medicines: Scut...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61K9/08A61P31/04A61P31/12A61P11/00
CPCA61K9/0053A61K9/08A61K35/747A61K36/064A61K36/355A61K36/539A61K36/634A61K2300/00
Inventor 任夕德赵方圆
Owner 任夕德
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