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'Shuang Huang Lian' pills and preparation method thereof

A technology of Shuanghuanglian pills and Scutellaria baicalensis, which is applied in the field of Shuanghuanglian pills and its preparation, can solve the problems of undisclosed content of forming agents, difficult curative effects of medicines, toxic and side effects, etc., and achieve the effects of clear use, precise curative effect, and convenient administration

Inactive Publication Date: 2006-12-20
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent application obviously has the following deficiencies: 1. As we all know, molding agents are an indispensable technical feature of traditional Chinese medicine forms, but the patent application documents only say that the pills contain auxiliary materials, but do not disclose the molding agents and their content
It can be seen that, if the weight range in the prescription disclosed in the patent application is used for compatibility, the prepared medicine will not only be difficult to have a definite curative effect, but may even produce other toxic and side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0036] Preparation of reference substance solution: Take an appropriate amount of baicalin reference substance, accurately weigh it, add 50% methanol to make a solution containing 0.05mg per 1ml, and obtain it.

[0037] The preparation of need testing solution: get this product under the item of weight difference, grind finely, get about 0.2g, put in 250ml measuring bottle, add 50% methanol right amount, put in water bath and keep warm for 20 minutes, ultrasonic treatment (power 250W, frequency 50Hz) for 20 minutes, dissolve, place at room temperature, add 50% methanol to dilute to the mark, shake well, filter, and take the filtrate to obtain the final product.

[0038] Determination method: Accurately measure 10 μl each of the reference substance solution and the test solution respectively, inject into the liquid chromatograph, inject into the liquid chromatograph, measure, and obtain.

[0039] According to each bag containing Scutellaria baicalin (C 21 h 18 o 11 ), each b...

example 1

[0048] Prescription: Forsythia 7.5kg

[0049] Honeysuckle 3.75kg

[0050] Scutellaria baicalensis 3.75kg

[0051] Stevioside 60g

[0052] Microcrystalline Cellulose 620g

[0053] Lactose 450g

[0054] Preparation:

[0055] 1. Preparation of Scutellaria baicalensis extract: Scutellaria baicalensis is decocted three times with water, the first time is 2 hours, the second and third times are 1 hour each, the decoction is combined, the dregs are filtered out, and the filtrate is concentrated to a relative density of 1.05 at 80°C. Clear the paste, add 2mol / L hydrochloric acid at 80°C until the pH of the solution is 1.5, keep it warm for 1 hour, let it stand for 24 hours, filter, wash the precipitate with water until the pH is 5.0, and then wash with 70% ethanol until the pH The value is 7.0, and it is dried at low temperature, and it is obtained;

[0056] 2. Soak honeysuckle and forsythia in warm water for half an hour, decoct twice for 1.5 hours...

example 2

[0064] Prescription: Forsythia 750g

[0065] Honeysuckle 375g

[0066] Scutellaria baicalensis 375g

[0067] Stevioside 6g

[0068] Microcrystalline Cellulose 400g

[0069] Preparation:

[0070] 1. Preparation of Scutellaria baicalensis extract: Scutellaria baicalensis is decocted three times with water, the first time is 2 hours, the second and third times are 1 hour each, the decoction is combined, the dregs are filtered out, and the filtrate is concentrated to a relative density of 1.08 at 80°C. Clear the paste, add 2mol / L hydrochloric acid at 80°C until the pH of the solution is 1.5, keep it warm for 1 hour, let it stand for 24 hours, filter, wash the precipitate with water until the pH is 5.0, and then wash with 70% ethanol until the pH The value is 7.0, and it is dried at low temperature, and it is obtained;

[0071] 2. After soaking honeysuckle and forsythia in water for half an hour, decoct twice for 1.5 hours each time, filter in several t...

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Abstract

The invention discloses a Shuanghuanglian pill and process of preparation, wherein the pill includes the aqueous extracts and plasticizers of the following raw materials (by weight portions): weeping forsythia 2 parts, root of large-flowered skullcap 1 part, honeysuckle flower 1 part, and plasticizer 0.13-1.1 part.

Description

technical field [0001] The invention relates to a Chinese patent medicine, in particular to a Shuanghuanglian pill and a preparation method thereof. Background technique [0002] Shuanghuanglian granules are obtained by extracting the three herbs of Scutellaria baicalensis, honeysuckle and forsythia, and then adding other auxiliary materials. Scutellaria baicalensis mainly contains active ingredients such as baicalin and baicalein; honeysuckle mainly contains active ingredients such as chlorogenic acid and caffeic acid; forsythia mainly contains active ingredients such as forsythol, forsythin, and forsythiaside. They share the functions of pungent and cool to relieve the exterior, clear away heat and detoxify, and can be used to treat fever, cough, sore throat and other symptoms caused by exogenous wind-heat. [0003] The dosage form of existing Shuanghuanglian preparation is dosage forms such as injection, oral liquid, syrup, granule, electuary, tablet (buccoli, chewable t...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61K9/20A61P11/04A61P11/14
Inventor 罗佳波谭晓梅
Owner SOUTHERN MEDICAL UNIVERSITY
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