41 results about "Arterial valve" patented technology

A plain-scan CT image aortic valve calcification segmentation system based on space-time priori comprises a position priori information extraction module, an encoding module and a decoding module, after an aortic image is automatically segmented in an off-line stage to obtain a segmentation mask, attention weights are generated through preprocessing and encoding, and the aortic valve calcification is subjected to image segmentation; and inputting the aorta image serving as a training set into a segmentation model comprising a position prior information extraction module, a coding module and a decoding module, and performing real-time image segmentation through the trained segmentation model in an online stage. According to the method, calcification point features of different sizes and forms are captured through multi-scale prediction; the aorta segmentation prior is introduced, the sensitivity and positioning precision of the model to aortic valve calcification are improved, coronary artery opening sequence time sequence information is introduced, a double-branch structure is adopted to adapt to structural differences, accurate positioning and recognition of aortic valve calcification lesions are achieved, and the false detection rate and the omission ratio are effectively reduced.

The utility model provides an anchoring device and a transcatheter artificial aortic valve system. The anchoring device is of an integrated structure and comprises an anchoring valve ring support at the telecentric end and an anchoring foot at the proximal end. The anchoring valve ring support is of a cylindrical net-shaped structure. The number of the anchoring feet is three, the anchoring feet are distributed on the periphery of the proximal end of the anchoring valve ring support, the anchoring feet have an abduction angle relative to the axis of the anchoring valve ring support, and each anchoring foot is of a C-shaped hollow structure. According to the anchoring device and the transcatheter artificial aortic valve system, after the anchoring device is released through a catheter, the anchoring foot is embedded into the aortic sinus bottom corresponding to the aorta root, the native valve is extruded between the anchoring foot and the artificial aortic valve, and a first anchoring state is formed; after the artificial aortic valve is expanded, the artificial aortic valve is tightly attached to the anchoring valve ring support and the aortic valve ring to form a second anchoring state; double anchoring provides a stable and reliable supporting effect for the artificial aortic valve.

The application discloses an aortic valve guide wire and a use method thereof, which comprises a head section, a transition section and a support section connected in sequence along an axial direction; the head section is composed of a polymer and further comprises a deformation capsule, at least one closed unit embedded in the head section, and an internal sealing electric field sensitive viscoelastic fluid; a mesh cable is arranged on the surface of the deformation capsule and extends to the transition section; the transition section and the support section are provided with a conductive film on the surface, and the conductive film is connected with the mesh cable and used for applying a non-uniform electric field to the deformation capsule to generate a regional viscosity difference and drive the head section to bend in a direction.The electric field sensitive viscoelastic fluid built in the head section generates a regional viscosity difference under the action of the non-uniform electric field, and the difference is converted into a directional bending moment through the synergistic effect of the mesh cable and the conductive film, so that the head of the guide wire can quickly respond to an external electric signal and accurately deflect.

The invention discloses a valve stent, an aortic valve and a mitral valve, and the valve stent comprises a valve stent which is of a latticed annular stent structure formed by cutting a metal tube; the outer frame is of a latticed or semi-latticed annular support structure formed by cutting a metal pipe, the outer frame wraps the outer side of the valve frame and is connected with the valve frame, and a first positioning unit is integrally formed on the outer frame; the first positioning unit comprises a plurality of supporting legs arranged in the circumferential direction of the outer frame, and the supporting legs are obtained by outwards bending and forming two adjacent edges in the grids or half grids of the outer frame in the circumferential direction, so that when the outer frame is implanted into the implantation position of the inner side of the autologous valve leaflet, the first positioning unit can be supported on the inner side of the autologous valve ring; the valve support is limited to move in the direction opposite to the heart blood flow direction. When the valve support is anchored through the outer support, the valve support provided with the outer support can still have the small radial size, and the implanting difficulty of the valve and the requirement for a conveying system are lowered.

The present invention provides an auxiliary occlusion device for aortic valve regurgitation. The auxiliary occlusion device comprises a positioning mechanism and an auxiliary occlusion member disposed proximal to the positioning mechanism. When the positioning mechanism is released, it is secured within the aorta, positioning the auxiliary occlusion member between the aortic valves. The auxiliary occlusion device can assist the aortic valve in occluding the gap between the aorta and the left ventricle in the presence of aortic valve regurgitation, thereby reducing or preventing blood backflow through the aortic valve. Furthermore, the auxiliary occlusion device does not obstruct blood flow in the aorta during ventricular contraction.

The application belongs to the technical field of interventional medical instruments, and particularly relates to a valve frame for a pulmonary valve and a pulmonary valve. The valve frame comprises a tubular middle part, a proximal end part and a distal end part connected to the axial two ends of the middle part respectively, the middle part comprises a plurality of grid structures, the distal end part comprises a plurality of unit bodies with an 'M' shape, and the number of the unit bodies is m, m is a natural number greater than or equal to 2. The pulmonary valve comprises a valve leaflet and the valve frame, and the valve leaflet is connected to the valve frame. The valve frame provided by the application can be uniformly expanded, and the overall shape is consistent. The pulmonary valve can be uniformly expanded by adopting the valve frame, and the use requirement that the pulmonary valve can be uniformly expanded is well met, and the use reliability is good.

The aortic valve comprises a valve body, a limiting rod, a connecting structure and a connecting piece, and the limiting rod is arranged on the far end side of the connecting structure; before the valve body is completely released, the far end of the connecting structure is arranged close to the valve body, one end of the limiting rod extends in the direction away from the valve body and protrudes out of the outer side of the valve body, and the far end of the connecting piece can penetrate in from the near end of the connecting structure, penetrate out from the far end of the connecting structure and is detachably connected with the valve body. After the valve body is completely released, the limiting rod can abut against the native valve leaflet in the body so as to limit the aortic valve to move towards the ventricle, the connecting piece can be separated from the valve body, and the connecting piece, the connecting structure and the limiting rod can be retracted into the conveying system so that foreign matter implanted into the body can be reduced, and the inflammation degree and foreign body sensation can be reduced. And the aortic valve is recovered into the sheathing canal and is repositioned and released, so that the accuracy of positioning and releasing the aortic valve is improved.

The present application provides a heart valve prosthesis, which has a first end and a second end opposite in a first direction; the heart valve prosthesis comprises a first support body, a second support body and an artificial valve leaflet; the first support body has a first edge and a second edge opposite in a second direction, which is perpendicular to the first direction; the second support body comprises a first segment, which is located on one side of the first support body and has a non-linear configuration; the first segment intersects the first edge at a first intersection point and intersects the second edge at a second intersection point; the second support body is connected with the first support body and allows the first segment to rotate relative to the first support body around a line connecting the first intersection point and the second intersection point; the artificial valve leaflet is connected with the edge of the second support body located on the side close to the first end and the first segment; the heart valve prosthesis has a contracted state and an expanded state; when the heart valve prosthesis switches from the contracted state to the expanded state, the first segment rotates and drives the middle part of the first segment to move in the direction close to the first end, and the distance between the middle part of the first segment and the first support body increases; when the heart valve prosthesis is in the expanded state, the area of the cross section of the artificial valve prosthesis perpendicular to the first direction first increases and then decreases along the first direction. The heart valve prosthesis can replace the native atrioventricular valve and / or the native arterial valve and has a larger effective valve orifice area.

The invention relates to an aortic valve and a conveying system.The aortic valve comprises a valve body and a limiting rod, one end of the limiting rod is connected with the valve body, the other end of the limiting rod extends in the direction away from the valve body to form a free end, and after the aortic valve is released, the limiting rod is connected with the valve body to form the free end; the limiting rod can abut against the native valve leaflet in the body so as to limit the aortic valve from moving towards the ventricle. And through the arrangement of the limiting rod, the accuracy of the aortic valve during releasing and the use safety can be improved, and the risk of an operation is reduced.

The invention discloses an aortic valve stent and an aortic valve, which are used for the aortic valve, so that the aortic valve can be suitable for being implanted in an aorta of an elbow structure. An anchoring unit is arranged at the position, close to the inflow end, of the aortic valve stent, the anchoring unit is located on one side of the aortic valve stent, and in the release process of aortic valve implantation, the anchoring unit is fixed to the autologous valve ring through interaction force between the anchoring unit and the autologous valve ring. The movement of the aortic valve stent on the side where the anchoring unit is arranged in the axial direction of the aortic valve is limited. Based on the anchoring function of the anchoring unit in the implanting and releasing process and the function of serving as a self-adjusting reference, the accuracy and reliability of the final implanting state and the implanting position of the aortic valve can be well guaranteed.

The invention provides application of HIPK2 and an inhibitor thereof in preparation of drugs for preventing or treating aortic valve calcification, it is found that the enzyme activity of HIPK2 is closely related to aortic valve calcification, regulation and control of the kinase activity of HIPK2 through the HIPK2 inhibitor may be a potential target spot for treating aortic valve calcification, and the HIPK2 inhibitor is matched to regulate and control the kinase activity of HIPK2, so that the aortic valve calcification can be treated. The technical problem of non-surgical drug treatment of aortic valve calcification diseases is solved, an effective drug treatment means is provided for the aortic valve calcification diseases, and the application prospect is good.

The invention relates to a surgical instrument for aortic valve stenosis caused by guide wire injury and an initiation method, and belongs to the field of construction of animal models of diseases, and the surgical instrument comprises a bottom plate (1) used for placing a mouse; the mouse fixing assembly is arranged on the upper end face of the bottom plate (1) and used for fixing a mouse; the aortic valve injury assembly is arranged on the upper end face of the bottom plate (1) and used for injuring the aortic valve of the mouse. Compared with the prior art, the surgical instrument for treating aortic valve stenosis caused by guide wire injury is provided, and the modeling process of an aortic valve guide wire injury model is scientifically standardized through the surgical instrument.

The invention discloses an aortic valve stent and an aortic valve device. The aortic valve stent is a self-expanding stent and comprises a stent body which is a tubular grid skeleton, and the end edge of the outflow end of the stent body comprises a plurality of edge grids and a plurality of grid notches which are distributed in a crossed mode in the circumferential direction; the outflow end release pieces are uniformly distributed at the outflow end of the stent main body in the circumferential direction and are correspondingly connected to the edge grids; the positioning pieces are evenly distributed at the outflow end of the support body in the circumferential direction and correspond to the grid notches, and the two ends of each positioning piece are connected to the two adjacent outflow end release pieces or the two edge grids; and in the direction from the outflow end to the inflow end of the opposite stent main body, the turning angle of the outflow end release piece or the edge grid to the connected positioning piece is an obtuse angle. By means of the mode, the aortic valve support can effectively reduce adverse effects generated by the outflow end of the aortic valve support.

The invention belongs to the technical field of biological medicines, and particularly relates to application of a succinate dehydrogenase complex B subunit SDHB as a therapeutic target to preparation of drugs for screening and preventing and / or treating aortic valve calcification. The invention proves that the ROR alpha agonist has a protective effect on CAVD through an SDHB-mediated mechanism. In short, succinic acid in the calcified aortic valve is metabolized and accumulated, and in-vitro supplementation of succinic acid promotes osteogenesis and calcification of aortic valve interstitial cells (h-VICs); the overexpression of ROR alpha improves the abnormal mitochondrial metabolism of h-VICs; sDHB is intervened to counteract aortic valve calcification mediated by the ROR alpha agonist to abnormal mitochondrial metabolism. Therefore, as a potential therapeutic target for aortic valve calcification, SDHB can be used for screening and preparing drugs for treating or preventing CAVD, and the technical problem that treatment can only be carried out through a valve replacement operation at present, and an effective drug treatment means is lacked is solved.

The invention discloses a transcatheter aortic valve conveying system, and relates to the technical field of interventional cardiology and medical instruments. The transcatheter aortic valve conveying system comprises a catheter base main limb, a catheter base side limb is fixed to one side of the catheter base main limb, a catheter body is fixed to one end of the catheter base main limb, and a center rod is fixed to one side of the catheter body; a limiting disc is fixed to the middle of the center rod, and two limiting ribs are fixed to one side of the center rod. According to the transcatheter aortic valve conveying system, the knob is manually rotated to rotate, the effect of convenient bending adjustment is achieved, the overall structure and surgical operation steps are simplified, the surgical time is shortened, a smooth inner wall is provided through the lining, the effect of stable use of the catheter is achieved, the structural stability in the conveying process is effectively guaranteed, and the service life of the catheter is prolonged. Due to the fact that the balloon has the core characteristic of being matched with valve conveying and releasing, the effect of safe use of the balloon component is achieved, and finally the functional effectiveness after the artificial valve is implanted is guaranteed.

The invention relates to an operation assisting system and a control method of the operation assisting system. The operation assisting system comprises a machine body, an actuator, a first adapter and a second adapter. The actuator is rotationally connected to the machine body and comprises a first transmission set and a second transmission set. The actuator has a first mounting position and a second mounting position relative to the machine body; at the first mounting position, the first adapter is detachably connected with the first transmission group; the first adapter is used for mounting a first aortic valve repair instrument; at a second mounting position; the second adapter is detachably connected with the second transmission group; and the second adapter is used for mounting a second aortic valve repair instrument. According to the operation auxiliary system, the position of the actuator relative to the machine body can be adjusted and controlled according to different clinical operation path requirements, an aortic valve replacement operation through a femoral artery operation path can be achieved, an aortic valve replacement operation through a cardiac apex operation path can also be achieved, and the requirement that a doctor is located on different operation sides of a patient is met.

The invention provides an aortic valve prosthesis additive forming method and system, and relates to the technical field of soft material additive manufacturing The method comprises the steps that a plane expansion model is generated according to a three-dimensional model of a to-be-formed prosthetic valve, and a trajectory strategy of additive forming and a tension combination of a tension device are preset; the sacrificial layer film is stretched according to the tension combination of the current printing layer through a tension device and fixed to a base plate, and prosthetic valve patterns are printed on the sacrificial layer film layer by layer through an additive forming device; the tension combination of the tension device is adjusted layer by layer, and the step S2 is repeated until all layers of the prosthetic valve are printed; the printed workpiece and the sacrificial layer film are removed together, the sacrificial layer film is dissolved through a dissolving agent, and a prosthetic valve sample is obtained through separation. The production time of the whole aortic heart valve prosthesis can be shortened, and production and application of personalized aortic heart valves more suitable for specific patients are facilitated.

The utility model discloses a pre-plasticized sheathing canal, a coronary angiography device and an interventional therapy device. The pre-plasticized sheathing canal comprises a catheter part, a bent leading-out part and a positioning part, wherein the catheter part is internally provided with a catheter cavity; the bent leading-out part is provided with a leading-out hole communicated with the catheter cavity; the conduit part is in smooth transition connection with the positioning part through the bent leading-out part; the positioning part can be placed in the internal area of the artificial aortic valve above the artificial valve leaflet for positioning; the plane where the positioning part in contact with the inner wall of the artificial aortic valve frame is located is obliquely arranged or vertically arranged at a certain angle relative to the catheter part; the bending leading-out part and the positioning part can be in an elastic deformation state when being subjected to external force, and after the external force is relieved, the bending leading-out part and the positioning part automatically recover to the original state. The guide-out position of the coronary angiography catheter or the coronary guide catheter can be guaranteed, and the convenience that the coronary angiography catheter or the coronary guide catheter enters the opening position of the coronary artery or extends into the coronary artery is improved.

The invention belongs to the technical field of interventional medical instruments, and particularly relates to a valve frame for a pulmonary valve and the pulmonary valve. The valve frame comprises a tubular middle body, a near-end body and a far-end body, the near-end body and the far-end body are connected to the two axial ends of the middle body respectively, the middle body comprises a plurality of grid structures, the far-end body comprises a plurality of M-shaped unit bodies, the number of the unit bodies is m, and m is a natural number larger than or equal to 2. The pulmonary artery valve comprises a valve leaflet and the valve frame, and the valve leaflet is connected to the valve frame. The valve frame can be evenly expanded, and the overall shape consistency is good. By adopting the valve frame, the pulmonary artery valve can be uniformly expanded, the use requirement on uniform expansion of the pulmonary artery valve is well met, and the use reliability is good.

The invention discloses a balloon structure of a transcatheter aortic valve delivery system, and relates to the technical field of interventional cardiology and medical instruments. The balloon structure of the transcatheter aortic valve conveying system comprises a catheter seat, and one end of the catheter seat is fixedly sleeved with an outer tube connecting piece and an inner tube connecting piece. According to the balloon structure of the transcatheter aortic valve delivery system, the tip connecting piece adopts the stepped design of accumulation of a plurality of circular rings or valve circular rings formed by injection molding of nylon materials, so that the effects of reducing the size of the connecting piece and reserving a larger gap are achieved, and the balloon filling effect is facilitated; the tip connecting piece makes contact with the inner wall of the blood vessel in the process of penetrating into the blood vessel of the human body, the flexible contact effect of the tip connecting piece and the inner wall of the blood vessel is achieved, the purpose of improving the use safety of the balloon structure is achieved, the flexible positioning effect is achieved after the tip connecting piece penetrates into the target position, and the effect of improving the implantation stability of the balloon structure is achieved.

The present invention relates to the field of medical imaging and in particular to a system (10) for processing medical image data for generating an image comprising a simultaneous representation of an arterial, valvular and myocardial state, wherein the system is adapted to perform the steps of: obtaining 3D medical image data (S101); identifying arterial, valvular and myocardial regions in the 3D medical image data by means of segmentation (S102); mapping the 3D medical image data to a 2D representation using a coordinate transform based on a spherical coordinate system with an origin depending on the identified valvular region and / or the identified arterial region (S104); generating a combined 2D image (50) indicative of the arterial-, valvular and myocardial state based on the 2D representation as an output (S104). The present invention further relates to a corresponding method (100),computer program and computer readable medium.

To enable an accurate implant of an artificial valve and a precise development thereof in an aortic valve replacement surgery.SOLUTION: Disclosed is an artificial aortic valve which can expand and shrink in a radial direction and suitable for an implant of a balloon of a delivery catheter in a radially-shrunk state. The artificial aortic valve includes a support frame having three rows extending in a circumferential direction of an angled strut. One row of optional two continuous angles struts of the angles strut extending in the circumferential direction forms a peak and recess. A row of adjacent angled strut is mutually connected via a link (a diamond-shaped cell or a rhombohedral) and forms two rows of cell. The artificial aortic valve includes three valve projections, an inner skirt, and an outer skirt. The support frame and the delivery catheter provides a method for easily and accurately developing the artificial aortic valve at a target part.SELECTED DRAWING: Figure 1

The invention provides a design method of an artificial aortic valve and the artificial aortic valve. The artificial aortic valve comprises a valve support and three valve leaflets. And the three valve leaflets are fixed on the valve bracket. The design method comprises the following steps: forming a shape curve of the valve stent, and generating the valve stent according to the shape curve of the valve stent. Based on the shape curve of the valve stent, a parameterization method of a power equation is adopted, and free boundary curves of the Tai Chi-like shape of the three valve leaflets are formed respectively. Based on the shape curve of the valve stent and the free boundary curve corresponding to the valve leaflets, abdomen curves of the three valve leaflets are respectively formed. And according to the shape curve of the valve stent, the free boundary curves of the three valve leaflets and the abdomen curves of the three valve leaflets, generating the three valve leaflets in a closed state. The obtained artificial aortic valve is better in performance.

The aortic valve stent comprises an outflow port end, the outflow port end comprises a plurality of stent units, the bottoms of the stent units are connected with a main frame supporting body, and the bottom of the main frame supporting body is connected with an inflow port; an inner support is arranged in a mesh formed by connecting each support unit and the main frame supporting body, an annular frame body is arranged on the main frame supporting body where the inner supports are located in the circumferential direction of the main frame supporting body, and the tops of the inner supports are bent outwards in the state that the tops of the inner supports are not connected with the annular frame body. The inner support capable of being detached and released again is arranged on the aortic valve support, the aortic valve support is provided with the inner support capable of being detached and released again, the aortic valve support is connected with the half-moon valve of the aortic valve, and therefore the half-moon valve of the aortic valve can be stretched and shaped; and the function of the aortic valve can be recovered under the condition that the bioprosthetic valve does not reach the replacement age limit or the replacement standard.

The invention relates to the technical application field of transcatheter artificial heart valves, and discloses a transcatheter aortic valve integrated skirt which comprises a valve support, an inner skirt edge is arranged on the inner side of the valve support, an outer skirt edge is arranged on the outer side of the valve support, and the inner skirt edge and the outer skirt edge are manufactured through an integrated forming process. A plurality of protruding supporting bosses are arranged on the side, away from the outer skirt edge, of the inner skirt edge, a plurality of leakage-proof assemblies are arranged on the side, away from the inner skirt edge, of the outer skirt edge, and a plurality of fixing assemblies are arranged on the inner side and the outer side of the valve support. The integrated inner skirt edge and outer skirt edge are free of suture lines, the hidden danger of perivalvular leakage caused by suture gaps is fundamentally eliminated, skirt edge dislocation caused by manual operation errors is avoided, meanwhile, bulb-shaped hollowed-out grooves formed by the adjacent leakage-proof bosses form pocket-shaped spaces, trace blood breaking through attachment gaps can be actively intercepted, and the leakage-proof effect is achieved. And the use safety of the artificial valve is improved.

To enable an accurate implant of an artificial aortic valve at an appropriate position and a precise development thereof.SOLUTION: Disclosed is an artificial aortic valve which can expand and shrink in a radial direction and suitable for an implant of a balloon of a delivery catheter in a radially-shrunk state. The artificial aortic valve includes a support frame having three rows extending in a circumferential direction of an angled strut. One row of optional two continuous angles struts of the angles strut extending in the circumferential direction forms a peak and recess. A row of adjacent angled strut is mutually connected via a link (a diamond-shaped cell or a rhombohedral) and forms two rows of cell. The artificial aortic valve includes three valve projections, an inner skirt, and an outer skirt. The support frame and the delivery catheter provides a method for easily and accurately developing the artificial aortic valve at a target part.SELECTED DRAWING: Figure 1

The application provides an aortic valve dynamic mathematical model parameterization modeling method and device, and particularly relates to the technical field of medical model construction. The scheme comprises the following steps: determining three reference points based on a plane in a three-dimensional coordinate system, and obtaining a bottom fixed point along the median line direction of a target line segment formed by two reference points; constructing an opening and closing motion curve, an abdominal edge curve and an attachment edge curve based on the three reference points and the fixed point; constructing a single valve leaflet by taking the opening and closing motion curve as a sweeping path and taking the abdominal edge curve and the attachment edge curve as sweeping curves, and pre-setting a plurality of control points to control the opening and closing motion curve, so as to obtain a single valve leaflet capable of dynamically changing; and repeating the above steps to construct an aortic valve dynamic mathematical model composed of three valve leaflets capable of dynamically changing. The scheme adjusts the positions of the reference points and controls the overall structure of the valve leaflet by changing the trend of the opening and closing motion curve, so that the dynamic change function of valve closing and opening is realized.

The invention discloses a transcatheter aortic valve conveying system bending adjusting mechanism, and relates to the technical field of interventional cardiology and medical instruments. The bending adjusting mechanism of the transcatheter aortic valve conveying system comprises a catheter base and a catheter body, and the catheter body is fixed to one end of the catheter base; the guide pipe further comprises a bending adjusting driving assembly, the guide pipe body penetrates through the bending adjusting driving assembly, a first sliding block or a second sliding block, a winding boss, a steel core and a pull wire are arranged in the bending adjusting driving assembly, the winding boss is fixed to one side of the first sliding block or one side of the second sliding block, and a through hole is formed in one side of the first sliding block or one side of the second sliding block. According to the bending adjusting mechanism of the transcatheter aortic valve conveying system, the first rotary knob or the second rotary knob is manually rotated to rotate, power transmission is achieved only by reserving cooperation of a single set of threads, a transmission link is simplified, the number of parts is reduced, the operation reliability of the mechanism is improved, meanwhile, the production and assembly difficulty and cost are remarkably reduced, and the production efficiency is improved. And compared with a traditional structure, the structure is more practical and economical.

The invention discloses an automatic pre-filling system for a dialysis machine, comprising a dialyzer, an extracorporeal circulation circuit and a dialysate circuit arranged in the dialyzer, wherein the extracorporeal circulation circuit comprises an arterial line and a venous line, and the extracorporeal circulation circuit is provided with a first pumping device, and the first pumping device allows the pre-filling liquid to pass through the arterial line, the dialyzer and the venous line; the arterial line is provided with an arterial pot, the arterial pot is provided with an arterial pressure interface and a liquid level detection device, the arterial pressure interface is connected to the air inlet of the exhaust line, and the exhaust line is provided with an arterial valve, a negative pressure air pump and an exhaust port in sequence, and / or, the venous line is provided with a venous pot, the venous pot is provided with a venous pressure interface and a liquid level detection device, the venous pressure interface is connected to the air inlet of the exhaust line, and the exhaust line is provided with a venous valve, a negative pressure air pump and an exhaust port in sequence. The present invention uses pre-filling liquid to automatically pre-fill a full set of lines and dialyzers, discharge gas, and fully moisten the dialysis membrane, which is convenient and fast, saves operation time, and ensures the dialysis effect.

The application relates to a manufacturing method of an aortic valve anchor, which comprises the following steps: cutting a base plate into an anchor semi-finished product in a planar unfolded state, and then cooperating with a shaping tool and heat treatment to axially stretch the anchor semi-finished product to form an anchor finished product in a three-dimensional state. The method omits the previous heat treatment step, reduces multiple shaping steps and heat treatment steps of a traditional shaping tool, directly stretches and shapes the final anchor, simplifies the process, avoids the instability caused by the traditional multiple heat treatment process and outward extension and shaping clamping, has small heat deformation, avoids the obstruction of the poor node formed at the bottom end of the positioning sinus of the anchor during implantation, improves the forming quality and use effect of the anchor, simultaneously reduces the manufacturing cost, and is favorable for improving the production efficiency.