26 results about "Arterial valve" patented technology

A plain-scan CT image aortic valve calcification segmentation system based on space-time priori comprises a position priori information extraction module, an encoding module and a decoding module, after an aortic image is automatically segmented in an off-line stage to obtain a segmentation mask, attention weights are generated through preprocessing and encoding, and the aortic valve calcification is subjected to image segmentation; and inputting the aorta image serving as a training set into a segmentation model comprising a position prior information extraction module, a coding module and a decoding module, and performing real-time image segmentation through the trained segmentation model in an online stage. According to the method, calcification point features of different sizes and forms are captured through multi-scale prediction; the aorta segmentation prior is introduced, the sensitivity and positioning precision of the model to aortic valve calcification are improved, coronary artery opening sequence time sequence information is introduced, a double-branch structure is adopted to adapt to structural differences, accurate positioning and recognition of aortic valve calcification lesions are achieved, and the false detection rate and the omission ratio are effectively reduced.

The application discloses an aortic valve guide wire and a use method thereof, which comprises a head section, a transition section and a support section connected in sequence along an axial direction; the head section is composed of a polymer and further comprises a deformation capsule, at least one closed unit embedded in the head section, and an internal sealing electric field sensitive viscoelastic fluid; a mesh cable is arranged on the surface of the deformation capsule and extends to the transition section; the transition section and the support section are provided with a conductive film on the surface, and the conductive film is connected with the mesh cable and used for applying a non-uniform electric field to the deformation capsule to generate a regional viscosity difference and drive the head section to bend in a direction.The electric field sensitive viscoelastic fluid built in the head section generates a regional viscosity difference under the action of the non-uniform electric field, and the difference is converted into a directional bending moment through the synergistic effect of the mesh cable and the conductive film, so that the head of the guide wire can quickly respond to an external electric signal and accurately deflect.

The present invention provides an auxiliary occlusion device for aortic valve regurgitation. The auxiliary occlusion device comprises a positioning mechanism and an auxiliary occlusion member disposed proximal to the positioning mechanism. When the positioning mechanism is released, it is secured within the aorta, positioning the auxiliary occlusion member between the aortic valves. The auxiliary occlusion device can assist the aortic valve in occluding the gap between the aorta and the left ventricle in the presence of aortic valve regurgitation, thereby reducing or preventing blood backflow through the aortic valve. Furthermore, the auxiliary occlusion device does not obstruct blood flow in the aorta during ventricular contraction.

The application belongs to the technical field of interventional medical instruments, and particularly relates to a valve frame for a pulmonary valve and a pulmonary valve. The valve frame comprises a tubular middle part, a proximal end part and a distal end part connected to the axial two ends of the middle part respectively, the middle part comprises a plurality of grid structures, the distal end part comprises a plurality of unit bodies with an 'M' shape, and the number of the unit bodies is m, m is a natural number greater than or equal to 2. The pulmonary valve comprises a valve leaflet and the valve frame, and the valve leaflet is connected to the valve frame. The valve frame provided by the application can be uniformly expanded, and the overall shape is consistent. The pulmonary valve can be uniformly expanded by adopting the valve frame, and the use requirement that the pulmonary valve can be uniformly expanded is well met, and the use reliability is good.

The present application provides a heart valve prosthesis, which has a first end and a second end opposite in a first direction; the heart valve prosthesis comprises a first support body, a second support body and an artificial valve leaflet; the first support body has a first edge and a second edge opposite in a second direction, which is perpendicular to the first direction; the second support body comprises a first segment, which is located on one side of the first support body and has a non-linear configuration; the first segment intersects the first edge at a first intersection point and intersects the second edge at a second intersection point; the second support body is connected with the first support body and allows the first segment to rotate relative to the first support body around a line connecting the first intersection point and the second intersection point; the artificial valve leaflet is connected with the edge of the second support body located on the side close to the first end and the first segment; the heart valve prosthesis has a contracted state and an expanded state; when the heart valve prosthesis switches from the contracted state to the expanded state, the first segment rotates and drives the middle part of the first segment to move in the direction close to the first end, and the distance between the middle part of the first segment and the first support body increases; when the heart valve prosthesis is in the expanded state, the area of the cross section of the artificial valve prosthesis perpendicular to the first direction first increases and then decreases along the first direction. The heart valve prosthesis can replace the native atrioventricular valve and / or the native arterial valve and has a larger effective valve orifice area.

The invention discloses an aortic valve stent and an aortic valve, which are used for the aortic valve, so that the aortic valve can be suitable for being implanted in an aorta of an elbow structure. An anchoring unit is arranged at the position, close to the inflow end, of the aortic valve stent, the anchoring unit is located on one side of the aortic valve stent, and in the release process of aortic valve implantation, the anchoring unit is fixed to the autologous valve ring through interaction force between the anchoring unit and the autologous valve ring. The movement of the aortic valve stent on the side where the anchoring unit is arranged in the axial direction of the aortic valve is limited. Based on the anchoring function of the anchoring unit in the implanting and releasing process and the function of serving as a self-adjusting reference, the accuracy and reliability of the final implanting state and the implanting position of the aortic valve can be well guaranteed.

The invention provides application of HIPK2 and an inhibitor thereof in preparation of drugs for preventing or treating aortic valve calcification, it is found that the enzyme activity of HIPK2 is closely related to aortic valve calcification, regulation and control of the kinase activity of HIPK2 through the HIPK2 inhibitor may be a potential target spot for treating aortic valve calcification, and the HIPK2 inhibitor is matched to regulate and control the kinase activity of HIPK2, so that the aortic valve calcification can be treated. The technical problem of non-surgical drug treatment of aortic valve calcification diseases is solved, an effective drug treatment means is provided for the aortic valve calcification diseases, and the application prospect is good.

The invention discloses a transcatheter aortic valve conveying system, and relates to the technical field of interventional cardiology and medical instruments. The transcatheter aortic valve conveying system comprises a catheter base main limb, a catheter base side limb is fixed to one side of the catheter base main limb, a catheter body is fixed to one end of the catheter base main limb, and a center rod is fixed to one side of the catheter body; a limiting disc is fixed to the middle of the center rod, and two limiting ribs are fixed to one side of the center rod. According to the transcatheter aortic valve conveying system, the knob is manually rotated to rotate, the effect of convenient bending adjustment is achieved, the overall structure and surgical operation steps are simplified, the surgical time is shortened, a smooth inner wall is provided through the lining, the effect of stable use of the catheter is achieved, the structural stability in the conveying process is effectively guaranteed, and the service life of the catheter is prolonged. Due to the fact that the balloon has the core characteristic of being matched with valve conveying and releasing, the effect of safe use of the balloon component is achieved, and finally the functional effectiveness after the artificial valve is implanted is guaranteed.

The utility model discloses a pre-plasticized sheathing canal, a coronary angiography device and an interventional therapy device. The pre-plasticized sheathing canal comprises a catheter part, a bent leading-out part and a positioning part, wherein the catheter part is internally provided with a catheter cavity; the bent leading-out part is provided with a leading-out hole communicated with the catheter cavity; the conduit part is in smooth transition connection with the positioning part through the bent leading-out part; the positioning part can be placed in the internal area of the artificial aortic valve above the artificial valve leaflet for positioning; the plane where the positioning part in contact with the inner wall of the artificial aortic valve frame is located is obliquely arranged or vertically arranged at a certain angle relative to the catheter part; the bending leading-out part and the positioning part can be in an elastic deformation state when being subjected to external force, and after the external force is relieved, the bending leading-out part and the positioning part automatically recover to the original state. The guide-out position of the coronary angiography catheter or the coronary guide catheter can be guaranteed, and the convenience that the coronary angiography catheter or the coronary guide catheter enters the opening position of the coronary artery or extends into the coronary artery is improved.

The invention discloses a balloon structure of a transcatheter aortic valve delivery system, and relates to the technical field of interventional cardiology and medical instruments. The balloon structure of the transcatheter aortic valve conveying system comprises a catheter seat, and one end of the catheter seat is fixedly sleeved with an outer tube connecting piece and an inner tube connecting piece. According to the balloon structure of the transcatheter aortic valve delivery system, the tip connecting piece adopts the stepped design of accumulation of a plurality of circular rings or valve circular rings formed by injection molding of nylon materials, so that the effects of reducing the size of the connecting piece and reserving a larger gap are achieved, and the balloon filling effect is facilitated; the tip connecting piece makes contact with the inner wall of the blood vessel in the process of penetrating into the blood vessel of the human body, the flexible contact effect of the tip connecting piece and the inner wall of the blood vessel is achieved, the purpose of improving the use safety of the balloon structure is achieved, the flexible positioning effect is achieved after the tip connecting piece penetrates into the target position, and the effect of improving the implantation stability of the balloon structure is achieved.

The present invention relates to the field of medical imaging and in particular to a system (10) for processing medical image data for generating an image comprising a simultaneous representation of an arterial, valvular and myocardial state, wherein the system is adapted to perform the steps of: obtaining 3D medical image data (S101); identifying arterial, valvular and myocardial regions in the 3D medical image data by means of segmentation (S102); mapping the 3D medical image data to a 2D representation using a coordinate transform based on a spherical coordinate system with an origin depending on the identified valvular region and / or the identified arterial region (S104); generating a combined 2D image (50) indicative of the arterial-, valvular and myocardial state based on the 2D representation as an output (S104). The present invention further relates to a corresponding method (100),computer program and computer readable medium.

To enable an accurate implant of an artificial valve and a precise development thereof in an aortic valve replacement surgery.SOLUTION: Disclosed is an artificial aortic valve which can expand and shrink in a radial direction and suitable for an implant of a balloon of a delivery catheter in a radially-shrunk state. The artificial aortic valve includes a support frame having three rows extending in a circumferential direction of an angled strut. One row of optional two continuous angles struts of the angles strut extending in the circumferential direction forms a peak and recess. A row of adjacent angled strut is mutually connected via a link (a diamond-shaped cell or a rhombohedral) and forms two rows of cell. The artificial aortic valve includes three valve projections, an inner skirt, and an outer skirt. The support frame and the delivery catheter provides a method for easily and accurately developing the artificial aortic valve at a target part.SELECTED DRAWING: Figure 1

The invention provides a design method of an artificial aortic valve and the artificial aortic valve. The artificial aortic valve comprises a valve support and three valve leaflets. And the three valve leaflets are fixed on the valve bracket. The design method comprises the following steps: forming a shape curve of the valve stent, and generating the valve stent according to the shape curve of the valve stent. Based on the shape curve of the valve stent, a parameterization method of a power equation is adopted, and free boundary curves of the Tai Chi-like shape of the three valve leaflets are formed respectively. Based on the shape curve of the valve stent and the free boundary curve corresponding to the valve leaflets, abdomen curves of the three valve leaflets are respectively formed. And according to the shape curve of the valve stent, the free boundary curves of the three valve leaflets and the abdomen curves of the three valve leaflets, generating the three valve leaflets in a closed state. The obtained artificial aortic valve is better in performance.

The invention relates to the technical application field of transcatheter artificial heart valves, and discloses a transcatheter aortic valve integrated skirt which comprises a valve support, an inner skirt edge is arranged on the inner side of the valve support, an outer skirt edge is arranged on the outer side of the valve support, and the inner skirt edge and the outer skirt edge are manufactured through an integrated forming process. A plurality of protruding supporting bosses are arranged on the side, away from the outer skirt edge, of the inner skirt edge, a plurality of leakage-proof assemblies are arranged on the side, away from the inner skirt edge, of the outer skirt edge, and a plurality of fixing assemblies are arranged on the inner side and the outer side of the valve support. The integrated inner skirt edge and outer skirt edge are free of suture lines, the hidden danger of perivalvular leakage caused by suture gaps is fundamentally eliminated, skirt edge dislocation caused by manual operation errors is avoided, meanwhile, bulb-shaped hollowed-out grooves formed by the adjacent leakage-proof bosses form pocket-shaped spaces, trace blood breaking through attachment gaps can be actively intercepted, and the leakage-proof effect is achieved. And the use safety of the artificial valve is improved.

To enable an accurate implant of an artificial aortic valve at an appropriate position and a precise development thereof.SOLUTION: Disclosed is an artificial aortic valve which can expand and shrink in a radial direction and suitable for an implant of a balloon of a delivery catheter in a radially-shrunk state. The artificial aortic valve includes a support frame having three rows extending in a circumferential direction of an angled strut. One row of optional two continuous angles struts of the angles strut extending in the circumferential direction forms a peak and recess. A row of adjacent angled strut is mutually connected via a link (a diamond-shaped cell or a rhombohedral) and forms two rows of cell. The artificial aortic valve includes three valve projections, an inner skirt, and an outer skirt. The support frame and the delivery catheter provides a method for easily and accurately developing the artificial aortic valve at a target part.SELECTED DRAWING: Figure 1

The application provides an aortic valve dynamic mathematical model parameterization modeling method and device, and particularly relates to the technical field of medical model construction. The scheme comprises the following steps: determining three reference points based on a plane in a three-dimensional coordinate system, and obtaining a bottom fixed point along the median line direction of a target line segment formed by two reference points; constructing an opening and closing motion curve, an abdominal edge curve and an attachment edge curve based on the three reference points and the fixed point; constructing a single valve leaflet by taking the opening and closing motion curve as a sweeping path and taking the abdominal edge curve and the attachment edge curve as sweeping curves, and pre-setting a plurality of control points to control the opening and closing motion curve, so as to obtain a single valve leaflet capable of dynamically changing; and repeating the above steps to construct an aortic valve dynamic mathematical model composed of three valve leaflets capable of dynamically changing. The scheme adjusts the positions of the reference points and controls the overall structure of the valve leaflet by changing the trend of the opening and closing motion curve, so that the dynamic change function of valve closing and opening is realized.

The invention discloses a transcatheter aortic valve conveying system bending adjusting mechanism, and relates to the technical field of interventional cardiology and medical instruments. The bending adjusting mechanism of the transcatheter aortic valve conveying system comprises a catheter base and a catheter body, and the catheter body is fixed to one end of the catheter base; the guide pipe further comprises a bending adjusting driving assembly, the guide pipe body penetrates through the bending adjusting driving assembly, a first sliding block or a second sliding block, a winding boss, a steel core and a pull wire are arranged in the bending adjusting driving assembly, the winding boss is fixed to one side of the first sliding block or one side of the second sliding block, and a through hole is formed in one side of the first sliding block or one side of the second sliding block. According to the bending adjusting mechanism of the transcatheter aortic valve conveying system, the first rotary knob or the second rotary knob is manually rotated to rotate, power transmission is achieved only by reserving cooperation of a single set of threads, a transmission link is simplified, the number of parts is reduced, the operation reliability of the mechanism is improved, meanwhile, the production and assembly difficulty and cost are remarkably reduced, and the production efficiency is improved. And compared with a traditional structure, the structure is more practical and economical.

The application relates to a manufacturing method of an aortic valve anchor, which comprises the following steps: cutting a base plate into an anchor semi-finished product in a planar unfolded state, and then cooperating with a shaping tool and heat treatment to axially stretch the anchor semi-finished product to form an anchor finished product in a three-dimensional state. The method omits the previous heat treatment step, reduces multiple shaping steps and heat treatment steps of a traditional shaping tool, directly stretches and shapes the final anchor, simplifies the process, avoids the instability caused by the traditional multiple heat treatment process and outward extension and shaping clamping, has small heat deformation, avoids the obstruction of the poor node formed at the bottom end of the positioning sinus of the anchor during implantation, improves the forming quality and use effect of the anchor, simultaneously reduces the manufacturing cost, and is favorable for improving the production efficiency.

The invention discloses an on-site installation type full endoluminal repair system for treating Stanford A-type dissection. The on-site installation type full endoluminal repair system comprises an ascending aorta stent-type blood vessel (ascending main assembly), a coronary artery branch covered stent-type blood vessel (coronary artery assembly) and a self-expanding aorta interventional valve (valve assembly) capable of being installed on site according to needs. The lifting main assembly is divided into a lifting main section and a sinus tube section, the lifting main section is a covered stent, the head end is anchored to an ascending aorta, the tail end is transited to be a concave sinus tube section, embedded branches are arranged at the two ends in a cavity of the covered stent in front of the concave part, openings are formed in the sinus tube section, and a metal bare stent is arranged outside the sinus tube section. The coronary artery branch covered stent is a conical small-caliber covered stent, the near end of the coronary artery branch covered stent is connected with an embedded branch of the lifting main assembly, and the caliber of the far end varies due to left and right coronary arteries. The graft may engage the aortic valve component as desired. The invention is specially used for treating the Stanford A-type dissection lesion of the aorta root, can repair the aortic lesion, reconstruct the bilateral coronary artery and connect the aortic valve as required, and can be produced in batches for emergency operations.

The invention discloses a patient personalized aortic valve design method based on iconography data. According to the method, on the basis of a clinical image, the position of a valve virtual base ring and the position of an aortic sinus-tube junction are gradually determined through a space structure where a left ventricle and an aorta are matched, the valve chimeric relation is determined through the aortic sinus-tube structure, and the valve chimeric relation is determined through the biomechanical law and Fermat point geometry principle in the chimeric relation. The method comprises the following steps of: finding out reasonable positions matched with valve embedding in three aortic sinus states with different sizes, and further reconstructing a closed surface structure between each valve leaflet according to the positions. According to the method, the method rule that all the valve leaflets are folded in the dead center during original aortic valve leaflet design is developed, personalized factors of the aortic sinus structure are introduced from the perspective of biomechanical reasonability, and on the objective premise that personalized differences exist in the sizes of the left crown sinus, the right crown sinus and the non-crown sinus, the design of the aortic valve leaflets is achieved. The invention discloses a method for finding a valve leaflet embedding position and designing a closed valve leaflet structure.

According to the pre-dilation balloon and the balloon dilation catheter assembly, the columnar balloon body is arranged in the middle of the pre-dilation balloon, the columnar balloon body is composed of the at least two balloon body units with the different outer diameters, the pre-dilation balloon can be arranged to be a reducing balloon, and therefore an anti-slipping step is formed in the middle of the pre-dilation balloon. In the pre-dilation process of the pre-dilation balloon, the anti-slip step is in contact with the calcified aortic valve, so that the friction force between the middle part of the pre-dilation balloon and the calcified aortic valve is increased, and the pre-dilation balloon is effectively prevented from shifting or slipping off from the calcified aortic valve in the pre-dilation process; the defect that the pre-expanded balloon is difficult to adapt to pre-expansion treatment of aortic valve calcification parts and lesion narrow parts due to the fact that the pre-expanded balloon is prone to displacement or slippage in the balloon pre-expansion link is overcome.

The invention relates to the field of medical instruments, and discloses a transcatheter aortic valve X-type valve leaflet valve frame and a connecting method thereof.The transcatheter aortic valve X-type valve leaflet valve frame comprises a first supporting frame, a second supporting frame and a valve leaflet structure, a plurality of X-type windows are formed between the first supporting frame and the second supporting frame, and the first supporting frame and the second supporting frame form an annular frame structure; the number of the valve leaflet structures is three, the valve leaflet structures are all arranged in the annular frame structure, a plurality of connecting structures are arranged at the joint of the first supporting frame and the second supporting frame and used for connecting and fixing the valve leaflet structures, and each connecting structure comprises a connecting block. By means of the arranged connecting lugs, stress isolation is achieved, the X-shaped suture structure is adopted, the connecting lugs are locked from multiple dimensions, complex stress from blood flow impact is effectively resisted and dispersed, the pain point that stress of a traditional valve suture point is concentrated, and valve leaflet tearing or fatigue failure is likely to be caused is solved, and the suture effect is improved. Therefore, the anti-fatigue performance and the long-term structural integrity of the valve are enhanced.

This invention relates to the field of medical device technology, and discloses an aortic valve stent and aortic valve assembly. The stent includes a stent body, which has a first mesh layer, a connecting rod layer, and a second mesh layer sequentially arranged from the inflow end to the outflow end. The first mesh layer is formed by multiple first mesh units with upper and lower double-layer V-shaped structures. The second mesh layer is formed by multiple V-shaped or inverted V-shaped second mesh units. The connecting rod layer includes multiple axial straight rods, with both ends of the straight rods connecting the first mesh layer and the second mesh layer respectively, and forming multiple large mesh openings between them to avoid the coronary artery opening. The outflow end of the stent has a suture ear fixing post, the top of which is flush with the end face of the outflow end and has a suture ear opening. This invention combines the coronary artery friendliness of a bulbar expansion stent with the excellent hemodynamic performance of a self-expanding stent, while reducing the grip size and shortening rate.

The embodiment of the utility model provides a percutaneous implantation artificial aortic valve capable of automatically filling a perivalvular leakage gap, and relates to the field of medical instruments. Comprising a valve support, the valve support is of a double-horn-shaped net structure formed by weaving metal wires, expansion layers are arranged on the opposite side walls of the metal wires corresponding to the waist of the valve support, the expansion layers correspond to the valve support in the circumferential direction, the expansion layers are made of expansion materials, and the expansion materials can expand after making contact with blood. The expansion layer is arranged on the waist portion of the valve support in the circumferential direction, the expansion layer is made of the expansion material, the expansion material absorbs moisture in blood after being connected with the blood and expands, the gap between the valve ring and the metal wire can be filled, and therefore the perivalvular leakage phenomenon is further reduced. After the stent is implanted into the aortic valve, a perivalvular leakage gap can be automatically filled, and perivalvular leakage is reduced.

The invention discloses an aortic valve guide wire and a using method thereof. The aortic valve guide wire comprises a head section, a transition section and a supporting section which are sequentially connected in the axial direction. The head section is made of a polymer, the deformation bag is embedded in at least one sealing unit in the head section, and electric field sensitive type viscoelastic fluid is sealed in the deformation bag; the net-shaped cable is arranged on the surface of the deformation bag and extends to the transition section; conductive films are arranged on the surfaces of the transition section and the supporting section, connected with the net-shaped cable and used for applying a non-uniform electric field to the deformation bag so as to generate regional viscosity difference and drive the head section to bend directionally. The electric field sensitive viscoelastic fluid arranged in the head section generates regional viscosity difference under the action of a non-uniform electric field, and the difference is converted into directional bending moment through the synergistic effect of the mesh cable and the conductive film, so that the guide wire head can quickly respond to an external electric signal and is accurately deflected.

The present invention specifically relates to the technical field of medical model construction, and provides an aortic valve dynamic mathematical model and a parametrized modeling method. The solution comprises: determining three reference points on the basis of a plane in a three-dimensional coordinate system, and obtaining a bottom fixed point along the direction of the perpendicular bisector of a target line segment formed by two reference points; constructing an opening-closing motion curve, a belly edge curve, and an attachment edge curve on the basis of the three reference points and the fixed point; constructing a single valve leaflet by taking the opening-closing motion curve as a sweep path and taking the belly edge curve and the attachment edge curve as sweep curves; presetting a plurality of control points to regulate the opening-closing motion curve to obtain a dynamically deformable single valve leaflet; and repeating the steps to construct the aortic valve dynamic mathematical model composed of three dynamically deformable valve leaflets. In the solution, by adjusting the positions of reference points and parameters, the overall structure of valve leaflets is controlled, and the trajectory of an opening-closing motion curve is changed, thereby achieving dynamic deformation of valves during closing and opening.