The invention relates to an uninterrupted blood flow cryoablation system, which comprises a balloon catheter, a bracket catheter and a guide wire, wherein the balloon catheter and the bracket catheterare connected through the guide wire; the balloon catheter comprises an abnormal-shaped balloon, a guide pipe, an injection adapter and a handle, and the abnormal-shaped balloon, the guide pipe, theinjection adapter and the handle are connected in sequence; the abnormal-shaped balloon is internally divided into three inner cavities, wherein the three inner cavities are independently connected with the injection adapter and the handle through the guide pipe; the bracket catheter comprises a pushing rod internally provided with a wire guiding cavity; the pushing rod comprises a bracket component, an inner pipe, an outer sheathing pipe and a sealing switch; and the guide wire comprises a pre-shaping structure positioned on the front end of the guide wire. According to the uninterrupted blood flow cryoablation system disclosed by the invention, through the guide wire, the guidance insertion of the cryoablation system is improved, through the supporting of the bracket component, a stablechannel is formed on the inner side of the balloon, vascular thrombosis due to balloon dilatation compression can be avoided, meanwhile, liquid nitrogen can be continuously input under an uninterrupted blood flow situation, the liquid nitrogen can be repeatedly and circularly pumped out and injected, and consequences of distal critical ischemia and the like due to target vessel occlusion during anoperation can be avoided.