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Reduced type glutathione lozenge

A technology of glutathione and reduced form, applied in tripeptide components, nervous system diseases, pill delivery, etc., can solve the problems of low bioavailability, poor curative effect, inconvenient use, etc., and achieve good taste, convenient administration, Guaranteed curative effect

Inactive Publication Date: 2003-04-09
福安药业集团庆余堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the deficiencies in the prior art, such as low bioavailability and poor curative effect of reduced glutathione tablets for injection, which are difficult for patients to accept and inconvenient to use for long-term use of reduced glutathione for injection. Treatment of liver disease, alcoholism, drug toxicity (such as tumor chemotherapy drugs, anti-tuberculosis drugs, psychoneurological drugs, antidepressant drugs, paracetamol, etc.), metal poisoning, radiation reactions and damage, with good absorption effect, convenient administration, good taste, Reduced glutathione drug lozenges with definite curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 (buccal tablet):

[0033] Reduced Glutathione 100g

[0034] Xylitol 60g

[0035] Microcrystalline Cellulose 20g

[0036] 10% starch slurry 10g

[0037] Menthol 3g

[0038] Aspartame 1g

[0039] Polyethylene glycol 6000 1g

[0040] Makes 1000 pieces

Embodiment 2

[0041] Embodiment 2 (buccal tablet):

[0042] Reduced Glutathione 300g

[0043] Mannitol 80g

[0044] Glucose 10g

[0045] 10% starch slurry 10g

[0046] Eucalyptus oil 2g

[0047] Stevia 2g

[0048] Sodium Lauryl Sulfate 1g

[0049] Makes 1000 pieces

Embodiment 3

[0050] Embodiment 3 (buccal tablet):

[0051] Reduced Glutathione 500g

[0052] Sorbitol 60g

[0053] Lactose 20g

[0054] 10% starch slurry 10g

[0055] peppermint oil 2g

[0056] Sucrose 10g

[0057] Stearic acid 1g

[0058] Makes 1000 pieces

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PUM

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Abstract

The reduced glutathione lozenge consists of flutathione as main componnet, stuffing, disintegrating agent, adhesive, absorption promoter, corrective and lubricant. The present invention produces reduced glutathione lozenge for absorption via oral cavity mucous membrane and entering blood circulation via jugular vein and superior vena cava, and this can aovid the decomposition of glutathione by intestinal peptidase and ensure high biological utilization and high curative effect.

Description

(1) Technical field [0001] The invention relates to reduced glutathione buccal tablets, in particular to a method for treating liver disease, alcoholism, drug toxicity (such as tumor chemotherapy drugs, anti-tuberculosis drugs, psychoneurological drugs, antidepressant drugs, paracetamol, etc.), metal poisoning, Radiation reaction and damage, the reduced glutathione lozenge that works mainly through buccal mucosa absorption. (2) Background technology [0002] Reduced glutathione is a tripeptide containing an active sulfhydryl group, which participates in a variety of important biochemical metabolic reactions in the body: participates in SH group redox reactions and related reactions, and the latter is a reaction that acts as a coenzyme; participates in sulfuric acid The production of uric acid and other detoxification mechanisms, and plays a number of roles in the protection or activation of SH enzymes or other cellular components - cell division or cell proliferation; it can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K38/06A61P1/16A61P25/32A61P39/02
Inventor 黄华
Owner 福安药业集团庆余堂制药有限公司
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