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Quality control method of total glycosides single preparation of white paeony roots

A technology of white peony root and preparation, which is applied in the field of quality control of white peony root preparations, can solve the problems such as quality control of traditional Chinese medicinal materials less used, and achieve the effect of guaranteeing quality and curative effect

Active Publication Date: 2011-08-03
NINGBO LIWAH PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There are some reports on the fingerprints of Radix Paeoniae Alba, but they are rarely used in the quality control of Chinese herbal medicines in production

Method used

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  • Quality control method of total glycosides single preparation of white paeony roots
  • Quality control method of total glycosides single preparation of white paeony roots
  • Quality control method of total glycosides single preparation of white paeony roots

Examples

Experimental program
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Effect test

preparation example Construction

[0055] ① Preparation of the test solution

[0056] Preparation of the test solution: Take about 0.1 g of the contents of the total glucosides of paeony capsules, accurately weigh it, put it in a 50ml measuring bottle, add about 35ml of dilute ethanol, ultrasonically treat it for 15min, take it out, let it cool, add dilute ethanol to the mark, Shake well. Precisely draw 5ml, put it in a 50ml measuring bottle, add dilute ethanol to the mark, shake well, and filter through a 0.45μm microporous membrane to obtain the product.

[0057] ② Preparation of reference solution

[0058] Preparation of reference solution: Take about 23 mg of paeoniflorin, weigh it accurately, put it in a 25ml volumetric bottle, dilute to the mark with methanol, and shake well; take about 7.5 mg of paeoniflorin, weigh it accurately, put it in a 25ml volumetric flask , dilute to the mark with methanol, and shake well; take 2ml each of paeoniflorin and paeonifloride respectively, put them in a 25ml measurin...

Embodiment 2

[0072] Content Determination of Paeoniflorin and Paeonifloride in Example 2 Total Glycosides of Paeony

[0073] ① Preparation of the test solution

[0074] Preparation of total glucosides of paeony for the test solution: Take about 0.1g of total glucosides of paeony powder, accurately weighed, put in a 50ml measuring bottle, add about 35ml of dilute ethanol, ultrasonicate for 15min, take it out, let it cool, add dilute ethanol to scale, shake well. Precisely draw 5ml, put it in a 50ml measuring bottle, add dilute ethanol to the mark, shake well, and filter through a 0.45μm microporous membrane to obtain the product.

[0075] ② Preparation of reference solution

[0076] Preparation of reference solution: Take about 23 mg of paeoniflorin, weigh it accurately, put it in a 25ml volumetric bottle, dilute to the mark with methanol, and shake well; take about 7.5 mg of paeoniflorin, weigh it accurately, put it in a 25ml volumetric flask , dilute to the mark with methanol, and shak...

Embodiment 3

[0088] The content determination of paeoniflorin and paeonifloride glucoside in Radix Paeoniae Alba in embodiment 3

[0089] ① Preparation of the test solution

[0090] Preparation of the test solution of Radix Paeoniae Alba: Take about 0.1g of the powder of this product, weigh it accurately, put it in a 50ml measuring bottle, add about 35ml of dilute ethanol, ultrasonically treat it for 30min, take it out, let it cool, add dilute ethanol to the mark, Shake well and filter through a 0.45um microporous membrane to obtain

[0091] ② Preparation of reference solution

[0092] Preparation of reference solution: Take about 23 mg of paeoniflorin, weigh it accurately, put it in a 25ml volumetric bottle, dilute to the mark with methanol, and shake well; take about 7.5 mg of paeoniflorin, weigh it accurately, put it in a 25ml volumetric flask , dilute to the mark with methanol, and shake well; take 2ml each of paeoniflorin and paeonifloride respectively, put them in a 25ml measuring ...

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Abstract

The invention provides a quality control method of a preparation of white paeony roots. The method comprises the following steps of: establishing a synchronous content measuring method of white paeony root herbs, white paeony root total glycosides and paeoniflorin and albiflorin in the white paeony root preparation by adopting the same liquid-phase chromatography condition; and accurately measuring the contents of the paeoniflorin and the albiflorin. The method is simple to preprocess a sample, keeps complete characteristic components and provides a stable sample solution and has higher accuracy, favorable reproduction and a certain specificity; characteristic peaks in the obtained fingerprint map have favorable separation effect, the fingerprint maps of the white paeony root herbs, the white paeony root total glycosides and the preparation have favorable relativity; the standard fingerprint map of the white paeony root herbs is established at a new angle by utilizing the relativity research of the fingerprint maps, can be used for identifying the qualities of the white paeony root herbs and improving the controllability of the production process of the white paeony root preparation and is favorable to ensuring the quality stability and the clinical curative effect of the white paeony root preparation.

Description

technical field [0001] The invention belongs to the technical field of medicine quality control, and in particular relates to a quality control method of Radix Paeoniae Alba preparation. The quality control method includes a content determination method and a fingerprint spectrum determination method. Background technique [0002] Fingerprint of traditional Chinese medicine is a hot topic in the quality control of traditional Chinese medicine in recent years. Compared with the previous quality detection methods of traditional Chinese medicine, fingerprint of traditional Chinese medicine is more specific. It not only includes the analysis of several known components, but also includes the analysis of known components. Relative content analysis between components and unknown components. Therefore, the fingerprint of traditional Chinese medicine reflects the comprehensive evaluation of the internal quality of traditional Chinese medicine, and is especially suitable for the qual...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71G01N30/36G01N30/88
Inventor 张新明周海滨饶毅江海龙夏川川杨海玲俞伟
Owner NINGBO LIWAH PHARM CO LTD
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