Traditional Chinese medicine preparation for treating peptic ulcer and preparation method thereof

A technology for peptic ulcer and traditional Chinese medicine preparations, which is applied to the digestive system, medical formulas, medical preparations containing active ingredients, etc., and can solve problems such as large dosage and aging of dosage forms

Inactive Publication Date: 2009-05-13
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the Chinese patent medicines used to treat peptic ulcer mainly include Weiyao Capsules, Weiwanshu Granules, Yangweining Capsules, Yesu Capsules, Pearl Weian Pills, Wubei Powder, and Compound Weining Tablets. Ulcer has a certain therapeutic or preventive effect, but most of the dosage forms are aging, and the dosage is large

Method used

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  • Traditional Chinese medicine preparation for treating peptic ulcer and preparation method thereof
  • Traditional Chinese medicine preparation for treating peptic ulcer and preparation method thereof
  • Traditional Chinese medicine preparation for treating peptic ulcer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1 of the present invention: the preparation of tablet:

[0049] Weigh 5g of Radix Paeoniae Alba, 10g of Atractylodes Rhizoma Atractylodes Rhizome, 10g of Atractylodes Rhizoma Atractylodes Rhizome and 5g of Evodia rutaecarpa, crush them through a 100-mesh sieve, mix them evenly, and dry them for later use; take 100-3000 mg of mixed medicine powder, 0.1-0.40 mg of magnesium stearate, carboxymethyl 4-12 mg sodium starch glycolate, 50-100 mg microcrystalline cellulose; mix the mixed drug powder with sodium carboxymethyl starch and microcrystalline cellulose, sieve, mix well, then add appropriate amount of water or ethanol to granulate, After drying, the granules are sized, magnesium stearate is added, and then the granules are compressed into tablets with a punching device to obtain tablets. The preparation is taken orally, 3 tablets each time, 3 times a day.

Embodiment 2

[0050] Embodiment 2 of the present invention: the preparation of hard capsule:

[0051] Weigh 10g of Radix Paeoniae Alba, 10g of Atractylodes Rhizome, 10g of Atractylodes Rhizome and 10g of Evodia rutaecarpa, mix them, add 8 times the amount of water, decoct 3 times, the first time is 3 hours, the second time is 2 hours, the third time is 1 hour, and the decoction is combined. Filtrate, concentrate the filtrate under reduced pressure (-0.06~-0.08Mpa, 80°C) to a clear paste with a relative density of 1.20 (50°C), dry under reduced pressure (-0.08Mpa, 70~80°C), pulverize, and pass through 100 mesh Sieve to obtain extract powder; take extract powder 100-3000 mg, magnesium stearate 0.1-0.30 mg, sodium carboxymethyl starch 4-12 mg, starch 50-100 mg; mix extract powder with carboxymethyl starch Sodium and starch are mixed evenly, then an appropriate amount of ethanol is added to granulate, dried, granulated, magnesium stearate is added, and then packed into gelatin capsules to obtai...

Embodiment 3

[0052] Embodiment 3 of the present invention: preparation of granules:

[0053] Weigh 10g of Radix Paeoniae Alba, 1g of Atractylodes Rhizome, 1g of Atractylodes Rhizoma Atractylodes Rhizome and 10g of Evodia rutaecarpa, mix them, reflux extract with 8 times the amount of 50% ethanol for 3 times, each time for 2 hours, filter, concentrate under reduced pressure (vacuum degree 0.06-0.08Mpa, temperature 80°C ) to a thick paste with a relative density of 1.35 (60°C), dried below 80°C, crushed through a 100-mesh sieve to obtain extract powder; take 1-10 grams of extract powder, 1-10 grams of dextrin or sucrose, and Appropriate amount of flavoring agent (such as essence) and sweetener (such as aspartame); mix the extract powder with sucrose / dextrin, flavoring agent and sweetener evenly, add appropriate amount of water or ethanol to make a soft material, and Sieve and granulate, dry, granulate, and package separately to obtain granules. The preparation is taken orally, 5 grams each ...

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Abstract

The invention discloses a traditional Chinese medicine preparation for curing peptic ulcer, and a preparation method thereof. The traditional Chinese medicine preparation is prepared by taking 1 to 10 parts of white peony root, 1 to 20 parts of white atractylodes rhizome, 1 to 20 parts of atractylodes rhizome and 1 to 10 parts of evodia fruit as the basic bulk drugs according to the parts by weight, and also can be combined with 1 to 10 parts of chickens gizzard-membrane, 1 to 20 parts of rhizoma corydalis, 1 to 20 parts of Chinese cinnamon and 15 to 20 parts of auckandia root. Compared with the prior art, the traditional Chinese medicine preparation has the effects of strengthening the spleen and stomach and promoting qi-circulation and relieving pain, and has good treatment effect for the gastric and intestinal diseases with main symptoms of gastric ulcer, doudenal ulcer, gastritis, abdominal pain and abdominal distention; and the traditional Chinese medicine preparation can reduce the dose for the patients to the utmost extent on the premise of ensuring the therapeutic effect of the drug.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine preparation for treating peptic ulcer and a preparation method thereof, belonging to the technical field of traditional Chinese medicine pharmacy. Background technique: [0002] Ulcer disease is a common chronic systemic disease, divided into gastric ulcer and duodenal ulcer, also known as peptic ulcer. The reason why it is called peptic ulcer is that gastric ulcer and duodenal ulcer were previously thought to be formed due to gastric acid and pepsin digesting the mucosa itself, but in fact gastric acid and pepsin are only one of the main causes of ulcer formation , there are other reasons for the formation of ulcer disease. Ulcer disease belongs to the categories of "epigastric pain", "stomach pain", "heartache" and "acid swallowing" in traditional Chinese medicine; According to the etiology, it can be divided into cold, heat, improper diet, fatigue, blood stasis, etc. and treat according to s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/754A61K9/00A61K9/16A61K9/20A61K9/48A61P1/04A61K35/37A61K35/57
Inventor 余丽梅
Owner ZUNYI MEDICAL UNIVERSITY
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