117results about How to "Dose less" patented technology

A system and method for tomographic image reconstruction using truncated limited-angle projection data that allows exact interior reconstruction (interior tomography) of a region of interest (ROI) based on the linear attenuation coefficient distribution of a subregion within the ROI, thereby improving image quality while reducing radiation dosage. In addition, the method includes parallel interior tomography using multiple sources beamed at multiple angles through an ROI and that enables higher temporal resolution.

Prodrugs of parent drugs and methods of making and using the same are described. The prodrugs comprise an amine-containing parent drug moiety and a prodrug moiety, such as methoxyphosphonic acid or ethoxyphosphonic acid. The prodrugs may be employed in therapy for the treatment of various indications, such as pain, and in methods of decreasing the abuse potential of abuse-prone drugs and / or delaying the onset of parent drug activity and / or prolonging parent drug activity as compared to administration of a parent drug.

The present invention relates to compositions comprising compounds which augment activated immune cells, such as T-cells, dendritic cells and natural killer ("NK") cells, and methods for the treatment or prevention of diseases and disorders, including cancer, inflammatory disorders, and infectious diseases, in a subject comprising the administration of said compositions to said subject. In particular, the present invention relates to methods for the treatment or prevention of diseases and disorders, including cancer, inflammatory disorders, and infectious diseases, in a subject comprising administrating to said subject one or more compounds that activate one or more cytokine receptors and one or more compounds that activate one or more co-stimulatory molecules expressed by activated immune cells. The present invention also relates to compositions and kits comprising a compound that activates one or more cytokine receptors and a compound that activates one or more co-stimulatory molecules expressed by activated immune cells.

The present invention provides topical formulations of ketotifen that provide a comfortable formulation when instilled in the eye and are effective in the treatment and prevention of ocular allergy, particularly allergic conjunctivitis. The invention further provides methods of treating and preventing ocular allergy by in a subject in need of such treatment by topical application of the ketotifen formulations of the invention to the eye of a subject in need thereof.

The invention provides a gear oil composition and a preparation method thereof. The gear oil composition comprises lubricating oil base oil and a 2, 2, 4-trialkyl-1, 2-bihydroquinoline antioxygen and a metal deactivator. The gear oil composition provided by the invention has excellent oxidation stability and extreme pressure antiwear property, and meanwhile has excellent low temperature mobility, viscosity-temperature characteristics, shearing stability and anti-bubbling property, good comprehensive performance, and is simple in preparation method and wide in application range.

Rapid melt tablets that dissolve and release an active component in the oral cavity are comprised of a pharmaceutical active ingredient such as dextromethorphan complexed with a resin that is effective in taste-masking the otherwise bitter taste of the active making it convenient for oral administration. The drug / resin-complexed particles can be coated with water swellable or water insoluble polymers to impart controlled release properties to the active ingredient. A rapid melt tablet also comprises diluents, sweeteners, flavors, disintegrants and other excipients to form granules that can be compressed into tablets at low pressure without the need for a binding agent.

A system and method for tomographic image reconstruction using truncated projection data that allows exact interior reconstruction (interior tomography) of a region of interest (ROI) based on the known sparsity models of the ROI, thereby improving image quality while reducing radiation dosage. In addition, the method includes parallel interior tomography using multiple sources beamed at multiple angles through an ROI and that enables higher temporal resolution.

The invention relates to an asphaltene deposit dispersant. The dispersant comprises the following components, by mass, 50-90% of a ketone, 5-45% of an asphaltene stabilizer, and the balance solvent, wherein the ketone comprises one or more of ketones having a general formula of R1CH(R2)COCH3, R1 and R2 are branched chain alkyl groups and can be same with each other or different from each other, and the sum of the carbon numbers of the R1 and the R2 is in a range of 10-50. The asphaltene deposit dispersant provided by the invention has the characteristics of high asphaltene deposit dissolving rate, small dosage, safety, and stability, is suitable for removing obstruction deposits in well holes in the viscous oil recovery process, and can also be used for dispersing obstruction objects near wells, or removing asphaltene deposits in ground pipelines and equipment in the pipeline transportation process.

The invention belongs to the technical field of oil-gas-water collecting and transporting and discloses an oil field crude oil pour point depressant and a preparing method of the oil field crude oil pour point depressant. The preparing method includes the steps that acrylic ester or metacrylic acid ester is mixed with perfluor carboxylic ester firstly, an organic solvent is added, the temperature rises, and stirring is conducted; then styrene is added, the temperature rises under the nitrogen protection, an organic solvent solution of an initiator is dripped, and a product A is obtained after a reaction; and finally, a-olefin, a polymer B and the product A are mixed and evenly stirred, and the oil field crude oil pour point depressant is obtained. The oil field crude oil pour point depressant has the paraffin prevention pour point depressing function, does not contain chlorine, is very suitable for transporting of crude oil of an offshore oil field and has the characteristics that the dosage is small, and the pour point depressing amplitude is large. The preparing method of the oil field crude oil pour point depressant is simple, a polar group containing fluorine is directly introduced into a molecular chain through a further reaction, the reaction process is easy to control, safe, reliable and environment-friendly, and high general applicability is achieved.

In one aspect, the present invention features HCV therapies comprising administering to a patient in need thereof an HCV protease inhibitor and ritonavir, wherein ritonavir is used as a pharmacokinetic booster to improve the pharmacokinetics of the HCV protease inhibitor. The HCV therapies do not require the testing of total cholesterol and triglyceride levels prior to and after the therapies.

A process for removing metals existing in the mode of nophthenate, especially calcium, from hydrocarbon oil includes mixing hydrocarbon oil with the aqueous solution of hydrochloric acid or nitric acid, water and demulsifier, emulsifying to change the metals into water-soluble ionic compound, and water-oil separation. Its advantages are low dosage of additive and high efficiency.

The invention discloses high-pressure anti-wear hydraulic oil, and belongs to the hydraulic oil field. The hydraulic oil comprises the following components in percentage by mass: 95-99% of base oil, 1.0%-1.5% of an extreme pressure anti-wear agent, 0.1-0.3% of a friction modifier; 0.4-1.0% of an antioxidant, 0.1-0.5% of an antirust agent, 0.1-0.5% of a metal deactivator, 0.02-0.1% of a detergent dispersant, 0.001-0.005% of an anti-foaming agent, and 0.1-0.5% of a demulsifying agent. Compared with the prior art, the hydraulic oil has the advantages of good viscosity-temperature performance, extreme pressure abrasion resistance, oxidation resistance stability, hydrolysis stability and thermal stability, and is not prone to aging and deterioration; the service life is prolonged, a friction pair can be normally lubricated under high-pressure and high-speed harsh conditions, and abrasion is reduced. The foam generated under the condition of violent mechanical stirring in the operation process can be quickly eliminated; air mixed in the oil can be released in a short time, and a static pressure can be accurately, sensitively and stably transmitted.

This invention has published a composition of medicine and its preparation, which can treat diabetes, hyperlipemia, fatigue and hypoxia. The preparation is as following: 300-1000 part-by-weight of prepared rehmannia root, 150-600 part-by-weight of prepa red dogwood fruit, 100-450 part-by-weight of tree peony bark, 150-600 part-by-weight of chinese yam, 100-450 part-by-weight of indian bread, 100-450 part-by-weight of alisma rhizome, right amount of refined edible vegetable oil are the materials; the tree peony bark is distilled; the residue of the tree peony bark after distillation, the prepared rehmannia root, the chinese yam and the indian bread are decocted to get the mixed liquor; the paeonol mother liquor is added into the mixed liquor to get extracturm I by centrifugation and concentration; the prepared dogwood fruit and the alisma rhizome are extracted in the refluxing alcohol; the extract is concentrated to get extracturm II; the extracturm I and II are mixed and concentrated to the thick paste; the thick paste is dehydrated in the vacuum, smashed and sifting; The refined paeonol is smashed and added into the extracturm powder; the mixed powder is added with right amount of supplementary materials and milled by the colloid mill, sifting screening; the fine powder is made into soft capsule. The invented capsule has the features of bringing into play in a shorter time, better curative effect and lower dose for oral administration, easier to administrate and stable product quality.

The present invention relates to new and improved interleukin-7 polypeptides, as well as compositions comprising the same, their preparation and uses. The invention more particularly relates to hyperglycosylated IL-7 polypeptides having improved properties, as well as their manufacture and therapeutic uses. The invention also discloses novel IL-7 polypeptides having modified amino acid sequences containing artificially created glycosylation site(s), as well as corresponding nucleic acid molecules, vectors and recombinant host cells. The invention also relates to the use of such polypeptides, cells or nucleic acids for curative or preventive treatment of mammalian subjects, including human subjects.

The invention relates to a marine cylinder lubricant composition. The cylinder lubricant composition comprises, by weight, 5-10% of an ultra-high base number sulphonate clearing agent, 3-8% of an ultra-high base number phenate clearing agent, 4-10% of an ultra-high base number naphthenate clearing agent, 0.5-2.5% of a dispersing agent, 0.5-1.5% of an antiwear agent, 40-60% of high viscosity indexClass I base oil 400SN / 500SN / 650SN or high viscosity index Class II base oil 400SN / 500SN / 650SN and 10-35% of Class I high viscosity index base oil HVIS 150BS. A method of compounding three clearing agents is adopted, so that respective outstanding advantages of the three clearing agents are utilized, defects of the three clearing agents are also made up, the comprehensive lubrication performance of marine lubricating oil is improved, and requirements of novel marine engines for lubricant performance can be met. Based on the premise that the composition is adapted to the traditional Class I base oil, the composition is compatible with the Class II base oil and is not restrained by base oil supply. The composition passes the original equipment manufacturer (OEM) authentication.

The invention discloses a method for removing metal in high-acid heavy crude oil. The method is characterized by comprising the following steps of: fully mixing and emulsifying the crude oil, a demetallization agent, injected water and a demulsifying agent at the temperature of 30-150 DEG C so that the metal in the crude oil enters into water phase in a form of a water-soluble ionic compound, wherein the mole number of the demetallization agent is 1-4 times total calcium mole number in the crude oil, the weight of the injected water is 2-10% that of the crude oil, and the demulsifying agent is 5-70ppm relative to the crude oil; and finally removing the metal by means of oil-water separation, wherein the crude oil demetallization agent comprises the following ingredients in percentage by weight: 20-40% of a chelating agent, 20-40% of inorganic acid, 0.1-5% of a dispersing agent or a surface active agent, 0.5-3% of a corrosion inhibitor and 20-40% of injected water.

A lateral decubitus precision patient support system and method for accurately and reproducibly positioning a patient's breast relative to a patient support surface to receive therapy, such as, but not limited to, radiation treatment, while the patient is in a lateral decubitus position (lying on the patient's side) upon a patient support surface is disclosed. The lateral decubitus precision support assembly may be securely attached to a treatment table during use. The lateral decubitus precision support assembly may include a contralateral breast module having at least one contralateral breast receiving area into which a contralateral breast of the patient may reside during breast therapy. The lateral decubitus precision support assembly may also include a treatment breast support that contacts a treatment breast of the patient to separate the treatment breast from the contralateral breast of patient to limit exposure of the contralateral breast to therapeutic procedures administered to the patient.

The present invention comprises an improved manipulator system having a remotely actuated tube walker assembly for reciprocally moving the manipulator along a tube bundle for inspection and repair of the tubes of the tube bundle wherein the tube walker has a movable inner section and an outboard section with both sections having groups of hydraulically actuated locking fingers which are selectively engageable with the tubes of the tube bundle so that when the fingers of the outboard section are locked the fingers of the inner section are disengaged and the inner portion can be moved axially to an aligned position with new tube locations.

The process of eliminating metal from hydrocarbon oil with acrylic acid-acrylate copolymer includes mixing the acrylic acid-acrylate copolymer with water injecting demulsifier and raw oil at 30-200 deg.c to make metal in hydrocarbon oil generate water soluble compound dissolved in water, and oil-water separation to eliminate metal from hydrocarbon oil. The acrylic acid-acrylate copolymer has molecular weight of 1000-50000, and molar ratio between acrylic acid structure units and acrylate structure units of 0.1-20. The copolymer consumption is 0.5-5 times, preferably 1.0-3.0 times, the total calcium weight in hydrocarbon oil. The process has the features of less copolymer consumption and high elimination efficiency, and may be used for hydrocarbon oil in excessive calcium content.

Conjugates of hydrophilic carboxy polysaccharides with protein members of the fibroblast growth factor (FGF) family and variants thereof. The conjugates provide a modified bioactivity and stability of FGFs for various therapeutic applications.

The invention provides a gear oil composition which comprises the following main components: (A) a low-alkali detergent with the mass accounting for 0.1%-2.0% of the total mass of the composition, (B) a sulfur-containing extreme-pressure anti-wear agent with the mass accounting for 1.0%-4.0% of the total mass of the composition, (C) an antioxidant with the mass accounting for 0.2%-2.0% of the total mass of the composition, (D) a ZDDP (zinc dialkyl dithiophosphate) oxidation and corrosion inhibitor with the mass accounting for 0.05%-1.0% of the total mass of the composition, (E) an oiliness agent with the mass accounting for 0.2%-1.2% of the total mass of the composition and (F) lubricating base oil, wherein a preparation method of the low-alkali detergent comprises the following steps: producing a saponification reaction of organic sulfur phosphonic acid, alkali metal and / or alkaline-earth metal oxide, water and alkyl salicylic acid with an inorganic acid and / or aryl carboxylic acid accelerant at the same time or successively, and collecting products. The gear oil composition is low in additive dosage and phosphorus content, relatively low in corrosivity, and relatively good in extreme pressure property and wear resistance, is a lubricating oil composition with excellent performance, and meets the requirements of low emission and environmental friendliness of lubricating oil.

The invention discloses a molybdenum modification dispersant, and a preparation method and applications thereof. The molybdenum modification dispersant comprises an imine diethanol molybdic acid diester group. The preparation method comprises the following steps: mixing succinic acid with alkyl chains and / or succinic anhydride with alkyl chains, alcohol amine compounds, and / or a diluent, carrying out first-phase reactions, removing residual unreacted substances that may exist, and adding a molybdenum reagent to carry out second phase reactions to obtain the target product. The molybdenum modification dispersant does not contain any sulfur or phosphor. Each molecule comprises an imine diethanol molybdic acid diester group, and thus the molybdenum content of the dispersant can be increased. Moreover, the raw material namely succinic acid with alkyl chains is commercial, the cost is largely reduced; the dispersant can generate a prominent high temperature synergetic antioxidant effect with alkylated diphenylamine antioxidant in lubricating oil; moreover, the dispersant can generate a good synergetic wear-resistant and friction reducing effect with zinc dialkyl dithiophosphate, the using amount of similar additive is reduced, the phosphor content is reduced, and the economy of fuel oil is improved.

The invention discloses a viscosity index improver for recombined type lubrication oil. The improved viscosity index improver for the lubrication oil is at least composed of the following components by weight: 0.1-30% of an ethylene-propylene copolymer (Olefin Copolymer, OCP), 0.1-30% of a styrene or styrene / conjugated diene (butadiene, isoprene) polymer (HSD) and 40-99.8% of base oil, wherein the olefin copolymer is grafted or mixed with a styrene or hydrogenated styrene / conjugated diene polymer. The olefin copolymer is grafted or mixed with the styrene or hydrogenated styrene / conjugated diene polymer; thickening capacity, shearing stability and low temperature viscosity of the viscosity index improver can be effectively improved through hydrocarbon recombination of the above two materials; at the same time, a viscosity index improver-adding amount can be greatly reduced; and production cost is reduced.