External applied preparations for treating intractable skin ulcer

Abstract

The invention relates to an externally applied preparation for treating skin wound, in particular to an externally applied preparation for treating chronic skin ulcer, which is characterized in that it comprises the effective components in weight as follows: insulin 500-5000u / 1000g, epidermal growth factor 0.001-0.01g / 1000g, antibacterials 5-20g / 1000g, others are adjuvant. It can treat a variety of infectious and protracted skin ulcer safely and effectively.

Description

technical field

[0001] The present invention relates to an external preparation for treating skin wounds, in particular to an external preparation for treating intractable skin ulcers. Background technique

[0002] Chronic intractable skin ulcer is a common disease, which is a localized defect of the skin and subcutaneous tissue or mucous membrane caused by a variety of reasons, often accompanied by different degrees of infection. Due to the long course of disease and the malnutrition of the wound, it is difficult to achieve natural healing of intractable ulcers. In my country's population aged 14 to 64, the incidence of chronic skin ulcers was 9.2% in men and 6.6% in women. The skin ulcer complicated by diabetic patients is a relatively stubborn chronic ulcer with tissue necrosis and local infection. The pathogenesis is complex. The main pathogenic factors include: vascular disease leading to ischemia and hypoxia; peripheral neuropathy leading to foot protective sensation ...

Examples

Embodiment 1

[0032] Example 1 consists of the active ingredients of the formulation by the following weights:

[0033] Insulin (human insulin) (5000u)

[0034] Epidermal Growth Factor (5mg)

[0035] Silver Sulfadiazine (10g)

[0036] Triethanolamine (20g)

[0037] Stearic acid (100g)

[0038] Glycerin (50g)

[0039] Lanolin (20g)

[0040] White Vaseline (150g)

[0041] Ethylparaben (1g)

[0042] Add distilled water to 1000g

[0043] Preparation method: the oil phase is stearic acid, lanolin, white petrolatum and ethyl paraben; the water phase is triethanolamine, glycerin and water; the water phase and the oil phase are stirred and heated to 70-80 ℃ respectively, and then the oil phase Slowly add the water phase while stirring well; when the temperature drops below 40°C, add insulin, epidermal growth factor and silver sulfadiazine, stir well and grind evenly, and t...

Embodiment 2

[0045] Example 2 consists of the following weights of formulation active ingredients:

[0046] Insulin (Bovine Insulin) (2000u)

[0047] Epidermal Growth Factor (5mg)

[0048] Silver Sulfadiazine (10g)

[0049] Triethanolamine (20g)

[0050] Stearic acid (100g)

[0051] Glycerin (50g)

[0052] Lanolin (20g)

[0053] White Vaseline (150g)

[0054] Ethylparaben (1g)

[0055] Add distilled water to 1000g

[0056] Preparation method: the oil phase is stearic acid, lanolin, white petrolatum and ethyl paraben; the water phase is triethanolamine, glycerin and water; the water phase and the oil phase are stirred and heated to 70-80 ℃ respectively, and then the oil phase The aqueous phase was added slowly while stirring well. When the temperature drops below 40°C, insulin, epidermal growth factor and silver sulfadiazine are added, and the mixture is fully stirr...

Embodiment 3

[0058] Example 3 consists of the active ingredients of the formulation by the following weights:

[0059] Insulin (Bovine Insulin) (500u)

[0060] Epidermal Growth Factor (10mg)

[0061] Gentamicin (10g)

[0062] Triethanolamine (20g)

[0063] Stearic acid (100g)

[0064] Glycerin (50g)

[0065] Lanolin (20g)

[0066] White Vaseline (150g)

[0067] Ethylparaben (1g)

[0068] Add distilled water to 1000g

[0069] Preparation method: the oil phase is stearic acid, lanolin, white petrolatum and ethyl paraben; the water phase is triethanolamine, glycerin and water; the water phase and the oil phase are stirred and heated to 70-80 ℃ respectively, and then the oil phase Slowly add the water phase while stirring well; when the temperature drops below 40°C, add insulin, epidermal growth factor or gentamicin, stir well and grind evenly, and that's it. Pack it...

technical field

[0001] The present invention relates to an external preparation for treating skin wounds, in particular to an external preparation for treating intractable skin ulcers. Background technique

[0002] Chronic intractable skin ulcer is a common disease, which is a localized defect of the skin and subcutaneous tissue or mucous membrane caused by a variety of reasons, often accompanied by different degrees of infection. Due to the long course of disease and the malnutrition of the wound, it is difficult to achieve natural healing of intractable ulcers. In my country's population aged 14 to 64, the incidence of chronic skin ulcers was 9.2% in men and 6.6% in women. The skin ulcer complicated by diabetic patients is a relatively stubborn chronic ulcer with tissue necrosis and local infection. The pathogenesis is complex. The main pathogenic factors include: vascular disease leading to ischemia and hypoxia; peripheral neuropathy leading to foot protective sensation ...

Examples

Embodiment 1

[0032] Example 1 consists of the active ingredients of the formulation by the following weights:

[0033] Insulin (human insulin) (5000u)

[0034] Epidermal Growth Factor (5mg)

[0035] Silver Sulfadiazine (10g)

[0036] Triethanolamine (20g)

[0037] Stearic acid (100g)

[0038] Glycerin (50g)

[0039] Lanolin (20g)

[0040] White Vaseline (150g)

[0041] Ethylparaben (1g)

[0042] Add distilled water to 1000g

[0043] Preparation method: the oil phase is stearic acid, lanolin, white petrolatum and ethyl paraben; the water phase is triethanolamine, glycerin and water; the water phase and the oil phase are stirred and heated to 70-80 ℃ respectively, and then the oil phase Slowly add the water phase while stirring well; when the temperature drops below 40°C, add insulin, epidermal growth factor and silver sulfadiazine, stir well and grind evenly, and t...

Embodiment 2

[0045] Example 2 consists of the following weights of formulation active ingredients:

[0046] Insulin (Bovine Insulin) (2000u)

[0047] Epidermal Growth Factor (5mg)

[0048] Silver Sulfadiazine (10g)

[0049] Triethanolamine (20g)

[0050] Stearic acid (100g)

[0051] Glycerin (50g)

[0052] Lanolin (20g)

[0053] White Vaseline (150g)

[0054] Ethylparaben (1g)

[0055] Add distilled water to 1000g

[0056] Preparation method: the oil phase is stearic acid, lanolin, white petrolatum and ethyl paraben; the water phase is triethanolamine, glycerin and water; the water phase and the oil phase are stirred and heated to 70-80 ℃ respectively, and then the oil phase The aqueous phase was added slowly while stirring well. When the temperature drops below 40°C, insulin, epidermal growth factor and silver sulfadiazine are added, and the mixture is fully stirr...

Embodiment 3

[0058] Example 3 consists of the active ingredients of the formulation by the following weights:

[0059] Insulin (Bovine Insulin) (500u)

[0060] Epidermal Growth Factor (10mg)

[0061] Gentamicin (10g)

[0062] Triethanolamine (20g)

[0063] Stearic acid (100g)

[0064] Glycerin (50g)

[0065] Lanolin (20g)

[0066] White Vaseline (150g)

[0067] Ethylparaben (1g)

[0068] Add distilled water to 1000g

[0069] Preparation method: the oil phase is stearic acid, lanolin, white petrolatum and ethyl paraben; the water phase is triethanolamine, glycerin and water; the water phase and the oil phase are stirred and heated to 70-80 ℃ respectively, and then the oil phase Slowly add the water phase while stirring well; when the temperature drops below 40°C, add insulin, epidermal growth factor or gentamicin, stir well and grind evenly, and that's it. Pack it...

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