48results about How to "Infection Prevention and Control" patented technology

The invention discloses a helicobacter pylori urease B antigenic epitope polypeptide and application thereof. The amino acid sequence of the antigenic epitope polypeptide is the sequence 37 in a sequence table, and the encoding gene sequence of the antigenic epitope polypeptide is the sequence 28 in the sequence table. The antigenic epitope polypeptide can stimulate organisms to generate helicobacter pylori resistant protective immune response so as to enhance the suppression of the helicobacter pylori infection, improve the capacity of removing germs of the organisms, and play a promoting role in development of corresponding vaccines, research on pathogenic mechanism, and clinical diagnosis.

The invention discloses a helicobacter pylori urease B antigen epitope polypeptide and application thereof. The amino acid sequence of the antigen epitope polypeptide is the sequence 34 in a sequence table, and the coding gene sequence of the antigen epitope polypeptide is the sequence 25 in the sequence table. The antigen epitope polypeptide provided by the invention can stimulate an organism togenerate helicobacter pylori resistance protective immunity reaction, thereby enhancing the effect of inhibiting helicobacter pylori infection, improving germ eliminating capacity of the organism, and playing an improving role in corresponding researches on development of vaccine and pathogenic mechanism and clinical diagnosis.

The invention discloses a helicobacter pylori urease B antigen epitope polypeptide and application thereof. The amino acid sequence of the antigen epitope polypeptide is the sequence 31 in a sequence table, and the coding gene sequence of the antigen epitope polypeptide is the sequence 25 in the sequence table. The antigen epitope polypeptide provided by the invention can stimulate an organism togenerate helicobacter pylori resistance protective immunity reaction, thereby enhancing the effect of inhibiting helicobacter pylori infection, improving germ eliminating capacity of the organism, and playing an improving role in corresponding researches on development of vaccine and pathogenic mechanism and clinical diagnosis.

The invention provides sepecific nucleic acid aptamer. The nucleotide sequence of the specific nucleic acid aptamer is a sequence shown in the sequence table <400>1, the nucleic acid aptamer is screened through a whole bacterium reduction SELEX technique, is low in molecular weight and easy to synthesize and modify, can recognize enterohemorrhagic escherichia coli O157:H7 in a high-specific mode and be combined with the enterohemorrhagic escherichia coli O157:H7 in a high-affinity mode, does not specifically combined with other bacteria, can be used for detecting the enterohemorrhagic escherichia coli O157:H7 and has the important significant for effectively preventing and controlling infection of the enterohemorrhagic escherichia coli O157:H7.

The invention relates to the field of animal virology and provides a duck parvovirus strain, live vaccine thereof and a preparing method. The strain is a duck parvovirus and specifically named GT2015v, and the biology preservation serial number of the strain is CCTCC No:V201528; the vaccine prepared by utilizing the strain effectively solves the problem that the disease can not be prevented at present in China, by means of continuous passage of duck embryos, a medium virulence isolate strain is attenuated and made to lose pathogenicity to ducks, good immunogenicity is kept, duck parvovirus infection can be prevented and controlled safely and effectively, cultivation risks are reduced, and sound development of duck breeding industry is guaranteed.

The invention provides a vaccine for preventing toxoplasma infection. The vaccine contains nucleotide sequences selected from the followings: 1) 736-2385th nucleotide sequences as shown in SEQ ID No.1, and/or 759-2411th nucleotide sequences as shown in SEQ ID No.3; 2) nucleotide sequences complementary with the nucleotide sequences as shown in 1); and 3) nucleotide sequences which perform substituting, deletion and addition modification on one or a plurality of basic groups of the nucleotide sequences as shown in 1) or 2). The vaccine has the capability of effectively preventing and controlling the infection of a toxoplasma animal model (Kunming mice), and the combination of recombinant plasmids can effectively improve the immune effect of a single-gene vaccine, therefore, plasmids pVAX-ROP5 and pVAX-GRA15 can be used as DNA (Deoxyribose Nucleic Acid) vaccine candidate antigens for preventing the toxoplasma infection; and a combined immune vaccine of a recombinant plasmid based on such two genes can be used as a cocktail composite vaccine for preventing the toxoplasma infection.

The invention firstly provides a nucleotide sequence used for infection prevention of toxoplasma gondii. The nucleotide sequence is selected from nucleotide sequences as follows: 1), a nucleotide sequence represented in a sequence table SEQIDNo.1; 2), a nucleotide sequence which is complementary with the nucleotide sequence represented in 1); and 3), a nucleotide sequence which performs substitution, loss and adding modification on one or more basic groups of the nucleotide sequence represented in 1) or 2) and has a toxoplasma gondii infection prevention function. The invention further provides a vaccine which comprises the nucleotide sequence and a medically acceptable carrier. The plasmid DNA vaccine pVAX-HSP60 can effectively prevent and control infection of a toxoplasma gondii animal model (a Kunming strain mouse), that is, the survival time of the mouse can be effectively prolonged, and worm count of brain cyst is reduced, so that the plasmid pVAX-HSP60 can be used as a DNA vaccine candidate antigen for resisting infection of toxoplasma gondii.

The present invention provides an external application wound repair liquid, which is characterized in that the repair liquid is prepared from sanguisorba, common bletilla tuber, japanese honeysuckle stem, and 75% ethanol. A preparation method of the external application wound repair liquid comprises: crushing the three herbs, uniformly mixing and filling into a container, adding the 75% ethanol, standing for a certain time, and carrying out repeated filtration to remove residues to obtain the external application wound repair liquid of the present invention. The external application wound repair liquid of the present invention can be used for various types of wounds, and has advantages of significant effect, simple preparation, easy use, and the like.

The invention relates to a PCV2, PCV3 and PCV4 triple subunit vaccine and a preparation method thereof, the PCV2, PCV3 and PCV4 triple subunit vaccine comprises three recombinant proteins, namely a PCV2 Cap protein, a PCV3 Cap protein and a PCV4 Cap protein, the PCV2 Cap protein is obtained by expressing a gene sequence as shown in SEQ ID NO.1 through escherichia coli, the PCV3 Cap protein is obtained by expressing a gene sequence as shown in SEQ ID NO.2 through escherichia coli, and the PCV4 Cap protein is obtained by expressing a gene sequence as shown in SEQ ID NO.2 through escherichia coli. The PCV4Cap protein is obtained by expressing a gene sequence as shown in SEQ ID NO.3 through escherichia coli. The invention also discloses a preparation method of the PCV4Cap protein. The vaccine can be used for preventing and treating PCV2, PCV3 and PCV4 infection at the same time, the immunogenicity aiming at PCV2, PCV3 and PCV4 is remarkably improved, and immunized animals can be induced to generate high-titer antibodies.

The invention discloses a muddy cranberry beverage. The muddy cranberry beverage is prepared from the following components in parts by weight: 21 to 26 parts of cranberry, 12 to 14 parts of semen nelumbinis, 8 to 10 parts of ginkgo fruit, 9 to 13 parts of fructus lycii, 8 to 10 parts of rosemary, 14 to 16 parts of rhoeo discolor, 4 to 6 parts of white granulated sugar, 0.01 to 0.03 part of a preservative and 0.2 to 0.4 part of an acidity regulator. The muddy cranberry beverage prepared by the invention effectively keeps nutrient substances in the raw materials and the prepared beverage has abundant nutrients and can be used for effectively preventing and treating various daily female urinary system symptoms including bacterial infection, urethritis, cystitis and chronic pyelonephritis; after being orally taken for a long period, the muddy cranberry beverage can be used for effectively alleviating symptoms including female dysmenorrhea and the like.

The invention discloses a sacral nerve electrical stimulation system, relates to the field of medical apparatus and instruments, and solves the problem that an existing sacral nerve electrical stimulator is liable to harm patients. A control unit comprises a boosting amplitude modulation unit, a pulse signal amplification unit, a master control unit, a human-computer interaction unit and a communication unit, wherein the master control unit is independently connected with the boosting amplitude modulation unit, the pulse signal amplification unit, the human-computer interaction unit and the communication unit; an emitter is connected with a receiver through the communication unit; the mater control unit controls the boosting amplitude modulation unit to output an adjustable voltage pulse signal; the pulse amplitude value of the adjustable voltage pulse signal is amplified to a required numerical value through the pulse signal amplification unit, and then, the required numerical value is transmitted to the emitter; the pulse signal emitted through the emitter is received through the receiver in a body to realize pulse signal stimulus for a corresponding neure; and the human-computerinteraction unit is used for displaying each parameter value of the pulse signal. The system is favorable for improving the bladder urination function of a spinal cord injury patient, and preventingand controlling urinary system infection.

The invention discloses a surface protein of streptococcus suis type-2, preparation method thereof and application. The surface protein of streptococcus suis type-2 is numbered as gi|146321522 in genebank; the preparation method of the surface protein comprises the following steps: cloning gene of the surface protein; connecting the gene and expression plasmid of Escherichia coli to transform the Escherichia coli; inducing expressing; separating and purifying expression product; and the like. The surface lipoprotein can be used as a diagnostic target, and a specific antibody of the protein can be detected in animals and people infected with the streptococcus suis; moreover, the surface lipoprotein is also an important protective antigen, and can be used for preparing vaccines.

The invention discloses a multifunctional ozone (blue oxygen) water health care machine. The machine comprises an ozone water generating device of which the water outlet end is connected with a heater, and the heater is connected with a flushing device and a water outlet handle used for cleaning and nursing of anorectum and/or skin through pipelines; a flushing head of the flushing device is provided with a second water outlet used for cleaning and nursing of buttocks and a third water outlet used for cleaning and nursing of private parts; the flushing device is also provided with a first water outlet used for cleaning the flushing head. The water outlet end of the ozone water generating device is connected to the flushing device through a pipeline and communicated with the first water outlet of the flushing device. The machine adopts several gas-liquid mixing technologies (blue oxygen tow mixing, jet mixing, air bubble mixing or blue oxygen electrolytic direct mixing), effectively dissolves ozone gas in water to make high-concentration ozone water, is used for washing and cleaning of anus, removal of rectum overnight stools, relieving and eliminating of hemorrhoid symptoms, cleaning and nursing of the buttocks and women's private parts and the like, and has dual functions of treatment and protection.