Chitosan emergent hemostasis material

Abstract

The invention provides a chitosan emergent hemostasis material, which is provided with at least two layers of structures: a chitosan hemostasis layer as an upper layer, and a polyacrylic acid grafting chitosan lining layer as a lower layer, wherein the chitosan hemostasis layer is of a structure of a porous microsphere, porous fiber, porous sponge, or a compound of the porous microsphere, the porous fiber and the porous sponge; and the polyacrylic acid grafting chitosan lining layer is of a structure of porous fiber, porous sponge, or a compound of the porous fiber and the porous sponge. According to the chitosan emergent hemostasis material, the polyacrylic acid grafting chitosan is used as the lining layer of the chitosan, so that powerful water suction force can be provided, seepage velocity of blood in the chitosan hemostasis material is improved, blood is further concentrated, the density of the hemostasis material is improved simultaneously, the hemostasis material is easier to sink to arrive at a bleeding point, gravity press of a bleeding part is formed, pressurization is convenient, and the hemostasis effect is improved. Meanwhile, the polyacrylic acid grafting chitosan layer also can be used as a medicine-carrying substrate, can be used for carrying antibacterial drug, acesodyne, factors for promoting tissue repair and the like, and is good for preventing and controlling infection while stopping bleeding, relieving pains, and accelerating wound tissue healing.

Description

technical field [0001] The invention relates to a chitosan hemostatic material, which belongs to the field of medical hemostatic materials. Background technique [0002] Hemostasis is an important part of surgery, especially first aid for war injuries and trauma. The current hemostatic materials mainly achieve the purpose of hemostasis by promoting the body's own blood coagulation function, supplementing exogenous coagulation factors, inhibiting fibrinolysis and contracting blood vessels. Chitosan is the deacetylation product of chitin, the only positively charged natural active polysaccharide discovered so far in nature, which can achieve significant hemostatic effect by absorbing and aggregating negatively charged red blood cells and forming blood clots . Because the hemostatic process does not depend on the body's own coagulation mechanism, the hemostatic effect is not affected even under low temperature and heparinized blood. In addition, the material is non-toxic, non...

AI Technical Summary

Problems solved by technology

U.S. Patent 7,371,403 describes a chitosan hemostatic bandage / hemostatic patch. The product HemCon hemostatic bandage is equipped with the U.S. military. It was well received in the Gulf War, but it is often difficult to find the bleeding when the arterial bleeding is stopped by non-professionals. point and affect the actual effect; U.S. Patent US2009 / 0186851A1, International Patent WO / 2009 / 130485, PCT / GB2009 / 001065 describe a granular chitosan hemostatic material, and the product Celox hemostatic powder formed by the hemostatic material is also effective for aortic bleeding It has shown good hemostatic effect and has been purchased by the military of many countries including the United States, Singapore, and the Philippines

However, the mass of Celox hemostatic granules is relatively light. In practical applications, especially when the injured are used for self-rescue, there are potential hidden dangers that it is inconvenient to use, difficult to reach the bleeding point, and difficult to exert its effect.

In addition, these hemostatic products only rely on chitosan itself to achieve auxiliary functions other than hemostasis, such as anti-inflammation, antibacterial, and tissue repair promotion, and the effect is very limited.

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