Abstract
The invention provides a chitosan emergent hemostasis material, which is provided with at least two layers of structures: a chitosan hemostasis layer as an upper layer, and a polyacrylic acid grafting chitosan lining layer as a lower layer, wherein the chitosan hemostasis layer is of a structure of a porous microsphere, porous fiber, porous sponge, or a compound of the porous microsphere, the porous fiber and the porous sponge; and the polyacrylic acid grafting chitosan lining layer is of a structure of porous fiber, porous sponge, or a compound of the porous fiber and the porous sponge. According to the chitosan emergent hemostasis material, the polyacrylic acid grafting chitosan is used as the lining layer of the chitosan, so that powerful water suction force can be provided, seepage velocity of blood in the chitosan hemostasis material is improved, blood is further concentrated, the density of the hemostasis material is improved simultaneously, the hemostasis material is easier to sink to arrive at a bleeding point, gravity press of a bleeding part is formed, pressurization is convenient, and the hemostasis effect is improved. Meanwhile, the polyacrylic acid grafting chitosan layer also can be used as a medicine-carrying substrate, can be used for carrying antibacterial drug, acesodyne, factors for promoting tissue repair and the like, and is good for preventing and controlling infection while stopping bleeding, relieving pains, and accelerating wound tissue healing.
Description
technical field
[0001] The invention relates to a chitosan hemostatic material, which belongs to the field of medical hemostatic materials. Background technique
[0002] Hemostasis is an important part of surgery, especially first aid for war injuries and trauma. The current hemostatic materials mainly achieve the purpose of hemostasis by promoting the body's own blood coagulation function, supplementing exogenous coagulation factors, inhibiting fibrinolysis and contracting blood vessels. Chitosan is the deacetylation product of chitin, the only positively charged natural active polysaccharide discovered so far in nature, which can achieve significant hemostatic effect by absorbing and aggregating negatively charged red blood cells and forming blood clots . Because the hemostatic process does not depend on the body's own coagulation mechanism, the hemostatic effect is not affected even under low temperature and heparinized blood. In addition, the material is non-toxic, non...
