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Dry potassium sodium dehydroandrographolide succinate powder inhalation and preparation method thereof

A technology for inhaling powder aerosol and Yanhuning, applied in the field of medicine, can solve problems such as poor absorption, and achieve the effects of rapid absorption, reduction of systemic toxic and side effects, and convenient use.

Active Publication Date: 2014-12-17
海南伊顺药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, Yanhuning used clinically is an injection, and it is made into a dry powder dosage form for direct use, and the absorption is relatively poor.

Method used

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  • Dry potassium sodium dehydroandrographolide succinate powder inhalation and preparation method thereof
  • Dry potassium sodium dehydroandrographolide succinate powder inhalation and preparation method thereof

Examples

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preparation example Construction

[0055] The present invention also provides a preparation method of Yanhuning inhalation powder, comprising the following steps:

[0056] Step 1: Grind Yanhuning finely, and use an ultrafine pulverizer to perform ultrafine pulverization to obtain an ultrafine powder with an average particle diameter of 1 μm to 5 μm: preferably, the average particle size of the ultrafine powder of Yanhuning obtained by ultrafine pulverization is The particle size is 2μm~4μm;

[0057] Step 2: Grinding the lactose with a high-speed grinding mill to obtain a fine powder with an average particle size of 60 μm to 80 μm; in order to improve the uniformity of the particle size, preferably, the average particle size of the lactose powder obtained by high-speed grinding and pulverization is 65 μm to 75 μm ;

[0058] Step 3: Mix the ground Yanhuning superfine powder and lactose micropowder in a mass ratio of 1:6-1:2, and pack them in capsules. In order to improve the effectiveness of the proportioning, ...

Embodiment 1

[0061] Grind Yanhuning (dehydrated andrographolide half-ester potassium succinate sodium salt) finely, and use an ultrafine pulverizer to perform ultrafine pulverization to obtain an ultrafine dry powder with a particle diameter of 1 μm to 5 μm: lactose (α-lactose monohydrate matter) is pulverized with a high-speed grinding mill to obtain a particle size of 60 μm to 80 μm micropowder; weigh 20g of Yanhuning superfine powder and 180g of lactose micropowder and mix, fill No. 3 capsules, each filling 200mg, and make 1000 capsules, namely have to.

Embodiment 2

[0063] Grind Yanhuning (dehydrated andrographolide half-ester potassium succinate sodium salt) finely, and use an ultrafine pulverizer to perform ultrafine pulverization to obtain an ultrafine powder with a particle diameter of 1 μm to 5 μm: mix lactose (α-lactose monohydrate ) is pulverized with a high-speed grinding mill to obtain a particle size of 60 μm to 80 μm micropowder; weigh 20 g of Yanhuning superfine powder and 240 g of lactose micropowder, mix well, fill No. 2 capsules, and each fills 260 mg to make 1000 capsules, namely have to.

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Abstract

The invention belongs to the field of medicines and particularly relates to a dry potassium sodium dehydroandrographolide succinate powder inhalation and a preparation method thereof. The dry potassium sodium dehydroandrographolide succinate powder inhalation is prepared by mixing superfine potassium sodium dehydroandrographolide succinate powder and lactose micropowder, wherein the mass ratio of the superfine potassium sodium dehydroandrographolide succinate powder to the lactose micropowder is (1:6)-(1:2), the average particle size of the superfine potassium sodium dehydroandrographolide succinate powder is 1-5mu m, and the maximum particle size of the superfine potassium sodium dehydroandrographolide succinate powder doses not exceed 10mu m; the average particle size of the lactose micropowder is 60-80mu m, and the maximum particle size of the lactose micropowder is 60-80mu m. The dry potassium sodium dehydroandrographolide succinate powder inhalation provided by the invention can be autonomously and actively inhaled by a patient through an inhalation device and is delivered to the lung to take effects, so that the toxic or side effect of the dry potassium sodium dehydroandrographolide succinate powder inhalation to the whole body is reduced; the dry potassium sodium dehydroandrographolide succinate powder inhalation can be autonomously inhaled without the help of the medical staff so as to be convenient to use; and the medical staff is low in preparation cost and relatively low in clinical application price.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a Yanhuning inhalation powder and a preparation method thereof. Background technique [0002] Yanhuning (14-dehydroxy-11,12-didehydroandrographolide-3,19-disuccinic acid half-ester potassium sodium salt monohydrate) is the plant Andrographis paniculata extract-andrographolide after esterification and dehydration , Dehydrated andrographolide half-ester potassium sodium salt refined into salt, and the active metabolite of Chuanhuning in vivo is the same substance (Chuanhuning is the monopotassium salt of andrographolide half-ester). [0003] Non-clinical pharmacological studies of andrographolide show that: (1) this product has a strong antipyretic effect on rabbits with fever caused by bacterial endotoxin, can promote the disappearance of fever, and the effect is rapid and lasts for more than 4 hours; (2) this product Can resist the increase of capillary wall permeability caus...

Claims

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Application Information

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IPC IPC(8): A61K9/72A61K31/365A61K47/26A61P31/04A61P29/00A61P25/20A61P31/14A61P31/16
Inventor 陈长潭孙立新李仁祥
Owner 海南伊顺药业有限公司
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