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Mucosal disease treatment system and application thereof

A disease treatment and mucosal technology, applied in the field of medicine, can solve the problems of insignificant effect, high irritation, large first-pass effect of drugs, etc., to achieve a wide range of applications and the effect of promoting rehabilitation

Inactive Publication Date: 2018-09-04
杭州易敏生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many adverse factors in this systemic drug delivery method, including: (1) large first-pass effect of the drug, large dosage, and low effective use rate of the drug; (2) large irritation and large side effects, especially some antibiotics, interferon, and steroids (3) It cannot provide a mild protective layer for the mucosal surface to prevent the mucosal surface from being re-stimulated by external substances, and it is difficult to avoid problems such as recurrence, slow effect, and ineffective effect.

Method used

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  • Mucosal disease treatment system and application thereof
  • Mucosal disease treatment system and application thereof
  • Mucosal disease treatment system and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Application of mucosal disease treatment system in the treatment of oral ulcers

[0076] First, the preparation of bioadhesives loaded with biomedical materials:

[0077] Component a: 2-20 parts by mass of sodium hyaluronate, 2-20 parts by mass of sodium alginate, and 20-50 parts by mass of hexadecylaminopolyamide-amine star polymer are dissolved in 1000 parts by mass of water;

[0078] Component b: 10-50 parts by mass of aldehyde-modified pullulan, 0.1-10 parts by mass of calcium pantothenate, 0.1-20 parts by mass of vitamin B2, and 0.1-20 parts by mass of vitamin C are dissolved in 1000 parts by mass of water.

[0079] Secondly, the method of use: cover the ulcer with a thin layer of component a through a dropper, cotton swab or spray bottle, and then spray component b through the spray bottle to quickly form a bioadhesive in situ on the ulcer , the adhesive firmly adheres to the ulcer, seals the ulcer, and releases sodium hyaluronate, sodium alginate, vitamin B2, an...

Embodiment 2

[0083] Application of mucosal disease treatment system in the treatment of oral injury mucosa

[0084] The oral mucosal injury in this embodiment mainly includes oral mucosal bites, scratches, punctures, bruises, etc., which have the characteristics of bleeding and rupture.

[0085] First, the preparation of bioadhesives loaded with biomedical materials:

[0086] Component a: take 20-50 parts by mass of hexadecylaminopolyamide-amine star polymer, 2-20 parts by mass of carboxymethyl chitosan, 2-20 parts by mass of sodium alginate, and 0.001-0.1 parts by mass of epidermal cells Growth factor (EGF), 0.001-0.1 parts by mass of fibroblast growth factor (bFGF), dissolved in 1000 parts by mass of water;

[0087] Component b: 10-50 parts by mass of aldehyde-modified pullulan and 0.1-10 parts by mass of calcium pantothenate are dissolved in 1000 parts by mass of water.

[0088] Secondly, how to use: cover the wound with a thin layer of component a through a dropper, cotton swab or sp...

Embodiment 3

[0091] Application of mucosal disease treatment system in the treatment of pharyngitis

[0092] First, the preparation of bioadhesives loaded with biomedical materials:

[0093] Component a: Take 10-100 parts by mass of ribavirin, 5-50 parts by mass of mercaptolated pullulan, 5-50 parts by mass of mercaptolated dextran, and 0.5-5 parts of sodium hyaluronate, dissolve in 1000 parts by mass of water;

[0094] Component b: 20-100 parts by mass of vinylsulfonated pullulan and 0.1-10 parts by mass of sodium alginate are dissolved in 1000 parts by mass of water.

[0095] Secondly, how to use: Spray component a to the throat through a spray bottle with a slender nozzle, and then spray component b to the throat to quickly form a bioadhesive in situ on the throat, and the adhesive is stable Adheres to the inflamed throat, protects the throat, and releases ribavirin and other medical materials.

[0096] The mechanical properties of the bioadhesive loaded with biomedical materials for...

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Abstract

The invention discloses a mucosal disease treatment system. The mucosal disease treatment system comprises a biological adhesive, a biological medical material, and medical instruments, wherein the biological adhesive comprises the following components: a component a, namely a functionalized star polymer or / and a functionalized comb polymer, and a component b, namely functional polysaccharide; anactive group of the component a and an active group of the component b can chemically react to form a new chemical bond; the biomedical materials, which are selected according to different mucosal diseases, are mixed in the component a of the biological adhesive, or in the component b of the biological adhesive, or partially mixed in the component a of the biological adhesive and partially mixed in the component b of the biological adhesive. When the system is in use, one of the components a and b is covered on a mucous membrane to be treated with the aid of a corresponding medical instrument,and the other component is covered on the previous component; the biological adhesive is firmly adhered to the mucous membrane and seals and repairs the mucous membrane; and the biological medical material is continuously released into adhesive tissues, thereby treating mucosal diseases.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a system for treating mucosal diseases and its application. Background technique [0002] The mucous membrane is the first line of defense of the human immune system, providing an important barrier for the human body to resist external adverse substances. However, the mucous membrane, as an important protective tissue of the human body, is often troubled by various diseases, and is difficult to cure, with high recurrence rate, long treatment cycle, slow effect, and ineffective effect. The main reasons are: [0003] First of all, the structural feature of the mucous membrane is a very thin layer of film, which is extremely fragile, so when it is subjected to hard foreign bodies, sharp objects, viruses, bacteria, irritating drugs, irritating foods, heat sources, radiation, smoke, alcohol, mental stress, sleep Insufficient immunity, low immunity, complications caused by diseases i...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/34A61K47/36A61K31/728A61K31/734A61K31/525A61K31/375A61K31/722A61K38/18A61K31/7056A61K38/48A61K31/14A61P1/02A61P11/04A61P1/04A61P15/02A61P17/02A61L31/04
CPCA61K9/7015A61K31/14A61K31/375A61K31/525A61K31/7056A61K31/722A61K31/728A61K31/734A61K38/1808A61K38/488A61K47/34A61K47/36A61L31/042A61P1/02A61P1/04A61P11/04A61P15/02A61P17/02A61K2300/00C08L3/04C08L1/286C08L5/08C08L5/00
Inventor 吴建华姚江平
Owner 杭州易敏生物医药科技有限公司
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