Toad venom lipophilic extract dry powder inhaler, as well as preparation method and application thereof

A technology of dry powder inhalation and extract, which is applied in the field of preparation of drugs for the treatment of lung tumors, can solve problems that have not been reported, and achieve the effects of increasing drug concentration, convenient application, and reducing toxic and side effects

Active Publication Date: 2013-05-08
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the study of dry powder inhalation of the fat-soluble extract of toadseye with anti-lung tumor effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Preparation of the fat-soluble extract of toad venom: take toad venom and wash it, add 10 times the amount of 95% (W / W) ethanol, reflux twice for 1.5 hours each time, filter and combine the filtrates, recover ethanol, concentrate to a thick paste, Dry at 60°C to obtain the fat-soluble extract of Bufoni.

[0026] 2. Preparation of the inhalant: the fat-soluble extract of Buad Phae is pulverized to D 50 Below 6 microns, mix with lactose with a particle size of 50-80 microns at a mass ratio of 1:12, pack the drug powder into capsules or blisters or dry powder inhalers to obtain inhalers.

Embodiment 2

[0028] 1. Preparation of toad venom fat-soluble extract: Take toad venom and wash it, add 12 times the amount of 95% (W / W) ethanol, reflux twice for 2 hours each time, combine the extracts and filter, concentrate the filtrate and spray dry , to obtain the fat-soluble extract powder of Bufoni, powder D 50 Below 5 microns.

[0029] 2. Preparation of the inhalant: Mix the fat-soluble extract powder of Bufona bufoi, lactose with a particle size of 80-125 microns, and leucine with a particle size of 30-50 microns at a mass ratio of 9:100:1, and pack Inhalers are obtained in capsules or blisters or dry powder inhalers.

Embodiment 3

[0031] 1. Preparation of the fat-soluble extract of toad venom: take toad venom and wash it, add 30 times the amount of 70% (W / W) ethanol, microwave-assisted extraction for 3 times, each time for 1 hour, combine the extracts and filter, concentrate the filtrate and carry out Spray drying to obtain the fat-soluble extract powder of Bufoni, powder D 50 Below 5 microns.

[0032]2. Preparation of the inhaler: packing the powder of the fat-soluble extract of toadseye into capsules, blisters or dry powder inhalers to obtain the inhaler.

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Abstract

The invention relates to a dry powder inhaler, and in particular relates to a dry powder inhaler prepared from toad venom lipophilic extract, a preparation method of the dry powder inhaler and an application of the dry powder inhaler in preparing a medicament for treating lung tumors. The toad venom lipophilic extract dry powder inhaler is characterized by consisting of toad venom lipophilic extract and pharmaceutically acceptable auxiliary materials in a mass ratio of 1:0-1:100. According to the dry powder inhaler, the dry powder inhaler prepared from the toad venom lipophilic extract can be used for directly acting on the focus of the lung, so that the occurrence of toxic or side effect can be reduced, and the bioavailability of the medicament can be improved. The dry powder inhaler can be used for overcoming the defects that an oral preparation is slow in response, has first-pass effect of liver and systemic toxic or side effect, low in preparation bioavailability, and can be used for solving the problems of using inconvenience, poor patient compliance and the like.

Description

[0001] This application is a divisional application of an invention patent application. The filing date of the original application was June 02, 2011, the application number was 201110147767.3, and the title of the invention was "a dry powder inhaler of a fat-soluble extract of Buad Phae and its preparation method and application". technical field [0002] The invention relates to a dry powder inhaler, in particular to a dry powder inhaler made of venom fat-soluble extract, a preparation method of the dry powder inhaler and an application in the preparation of a drug for treating lung tumors. Background technique [0003] Toad Su is the secretion of the epidermal glands of Bufobufo gargarizans Cantor, an animal of the Bufonidae family. It has multiple functions such as detoxification, analgesia, resuscitation, and anti-tumor. It is used for middle and late stage tumors, chronic hepatitis B and other diseases. . Bufotoxins and their hydrolysis products, bufageins and bufot...

Claims

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Application Information

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IPC IPC(8): A61K9/72A61K9/14A61K35/56A61P35/00A61K35/65
Inventor 陈彦张振海贾晓斌吴青青周蕾
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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