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2 results about "First pass effect" patented technology
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The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. It is the fraction of drug lost during the process of absorption which is generally related to the liver and gut wall. Notable drugs that experience a significant first-pass effect are imipramine, morphine, propranolol, buprenorphine, diazepam, midazolam, pethidine, cannabis, cimetidine, lidocaine, and nitroglycerin. In contrast some drugs are enhanced in potency: for example, the effect of the most commonly considered active ingredient in cannabis, THC, is enhanced by transformation of a significant portion into 11-hydroxy-THC that more readily crosses the blood brain barrier and thus achieves greater potency than the original THC. [Cannabis edible]
A sustained-release transdermal patch containing magnolia lipoprotein, its preparation method and application
PendingCN122272540ATransdermal patchDrugs solution
This invention discloses a sustained-release transdermal patch containing magnolia oleoresin, its preparation method, and its application, belonging to the field of traditional Chinese medicine external preparation technology. The patch consists of a gel layer containing magnolia oleoresin extract, a backing layer, and a protective film. Sodium polyacrylate, PVP K90, glycerin, and chitosan quaternary ammonium salt are used as the gel matrix, with the addition of high-purity magnolia oleoresin extract and a penetration enhancer. The preparation method includes ethanol extraction and macroporous resin purification of magnolia oleoresin from magnolia oleoresin, preparation of a blank matrix, preparation of the drug solution, drug loading and mixing, coating and molding, and drying and cutting. The process is stable and controllable. The transdermal patch prepared by this invention can achieve sustained transdermal drug release, bypassing the first-pass effect of the liver. It is convenient to use, has high compliance, and provides a safe and effective new formulation for the treatment of rhinitis.
Owner:HEILONGJIANG UNIV OF CHINESE MEDICINE
New Uses of Atractylodes macrocephala essential oil for hair growth
This invention provides a novel use of Atractylodes macrocephala essential oil for the prevention and treatment of hair loss and alopecia areata. The characteristic components of the Atractylodes macrocephala essential oil include: atractylenolide I, atractylenolide II, atractylenolide III, atractylone, β-elemene, hesperidin, and isohesperidin. The invention also provides a method for preparing essential oil compositions, pharmaceutical formulations, and uses for the prevention and treatment of hair loss and alopecia areata. This method reduces bitterness and the first-pass effect in the liver, resulting in more stable blood drug concentrations and improved patient compliance. Compared to existing methods, it has advantages such as better efficacy and no toxic side effects. Developing health products and pharmaceuticals for the prevention and treatment of hair loss and alopecia areata based on this method has great potential.
Owner:田薇