163 results about "First pass effect" patented technology

The present invention discloses a compound licorice lozenge and its preparation method. Its prescription includes licorice extract powder and powdered opium, etc. and it is characterized by that it also includes off-odor removing agent, filling agent, mucilage and correctives, in which the off-odor removing agent can invest and adsorb the putrid odor produced by camphor and anise star oil, and said lozenge has good taste, has no special putrid odor, and its effective component can be directly acted on the pharyngeal portion, laryox portion and trachea region of oral cavity, so that it can obtain obvious effect for removing the phlegm, relieving cough, relieving inflammation and killing bacteria.

A spray of tree frog's antibacterial peptide for treating burn, scald, and skin infection is prepared from antibacterial peptide of tree frog, nipagin ethylester, PEG 400, sodium chloride and water through preparing auxiliary solution, adding the antibacterial peptide of tree frog and water, stirring and loading in sprayer.

A snuff for preventing and treating senile dementia, improving memory and regulating the permeability of blood brain barrier is prepared from the active component(s) chosen from eugenol, its salt, its isomer and their mixture, and selective natural spice.

The invention discloses a freeze dried injection containing coenzyme Q#-[10], which comprises coenzyme Q#[10] and surface active agent, wherein the surface-active agent is the mixture of Twain and polyoxyl stearate, the medicinal active component being coenzyme Q#-[10], the weight ratio of coenzyme Q#[10] and Twain is 1:1-1:50, the weight ratio of coenzyme Q#[10] and pollyoxyl stearate is 1:1-1:50.

The invention provides the application of a 1,6-fructose diphosphate sodium salt, fructose and / or borneol composition to the preparation of an antiepileptic drug. The composition consists of 1,6-fructose diphosphate sodium salt and fructose, or 1,6-fructose diphosphate sodium salt and borneol combination, or 1,6-fructose diphosphate sodium salt, fructose and borneol. The composition provided by the invention can improve in vivo stability of 1, 6 1,6-fructose diphosphate, in order to maintain high level of 1,6-fructose diphosphate in the brain for a long time and make the 1,6-fructose diphosphate sodium salt exert antiepileptic effect for a long time. The composition provided by the invention particularly employs chewable tablets, orally disintegrating tablets and dispersible tablets as dosage forms for the antiepileptic drug, and the dosage forms can be directly absorbed in oral mucosa, avoid hepatic first-pass effect and further increase the level of 1,6-fructose diphosphate in the brain, thereby further improving the antiepileptic efficacy of the drug.

The present invention belongs to the field of medicine technology, and is especially oral loratadine disintegrating tablet for treating allergic diseases and its preparation process. The oral loratadine disintegrating tablet includes loratadine as effective medicine component, and excipient mixture comprising disintegrating agent, stuffing, soluble polyol and penetrant. The oral loratadine disintegrating tablet consists of loratadine 20-50 wt%, disintegrating agent 5-15 wt%, stuffing 10-30 wt%, soluble polyol 30-60 wt%, and penetrant 1-5 wt%. The oral loratadine disintegrating tablet, after being disintegrated fast, can cover gastrointestinal mucous membrane widely, and has fast acting, no first pass effect, high bioavailability, and convenient taking.

The invention discloses a preparation method of an oral folic acid instantly-dissolved membrane, and the method comprises the following steps: (1) weighing raw materials and auxiliary materials comprising a film-forming material, a filler, a sweetening agent, a plasticizer, a disintegrating agent and folic acid; (2) evenly mixing the folic acid, the sweetening agent, the disintegrating agent, the filler and the film-forming material, adding purified water, stirring evenly; after full swelling, adding the plasticizer, placing for completely swelling, degassing, and coating; and (3) drying, demoulding, cutting to obtain the oral folic acid instantly-dissolved membrane. The oral folic acid instantly-dissolved membrane tastes good, the oral folic acid instantly-dissolved membrane can be taken without drinking water, and can be instantly dissolved in the oral cavity without first pass effect, medication compliance of patients is high, and the need of the use of special flavoring agent is eliminated. The preparation method is simple, short in time and low in cost.

A spray of diversine hydrochloride is prepared from the tuduranine hydrochloride, percutaneous promoter and solvent. Its advantages are high percutaneous effect and curative effect, quick absorption, and low toxic by-effect.

The invention relates to loratadine lyophilized tablets, and a lyophilization prescription and a technology thereof. The loratadine lyophilized tablets provided by the invention are prepared from a main medicine loratadine and medicinal auxiliary materials. When the tablets are taken, no water is used, and the tablets disintegrate rapidly in mouths. Therefore, the tablets are suitable for patients with swallowing difficulties such as old people and children. Also, the tablets are suitable to be used in trips with water source shortages. The tablets are advantaged in convenient administration, fast absorption, small first-pass effect, and small irritation to gastrointestinal mucous membranes. The market prospect of the tablets is wide. With the lyophilized tablets provided by the invention, side effects of loratadine can be substantially reduced. Also, the invention relates to a preparation method of the loratadine lyophilized tablets.

The invention relates to rotundine orally disintegrating tablets and a prescription and process for preparing the rotundine orally disintegrating tablets by adopting a freeze drying method. The rotundine orally disintegrating tablets are prepared from rotundine as a main medicine and pharmaceutic adjuvants, can be taken without water, are capable of rapidly disintegrating after entering the mouth, are suitable for taking by patients suffered from dysphagia, such as the old, children and the like, are simultaneously suitable for medications in the travel journey under the condition of being not easy to obtain a water source, has the advantages of convenience for taking, high absorption speed, small fast pass effect, little irritation to digestive tract mucosa, wide market application prospect and the like, and are capable of remarkably reducing side effects of rotundine. In addition, the invention also relates to a preparation method of the rotundine orally disintegrating tablets.

The invention relates to a luleitadingmione oral calving tablet which can treat allergic rhinitis, etc. wherein, it has quick adsorption, high biological utilization, and simple intake method without water. It uses Loratadine and bromamine acid as materials, with some findings.

The hydrophilic plaster for treating dysmenorrheal consists of indometacin 0.15-6 wt%, salbutamol 0.01-3 wt%, transdermal promoter 0.5- 10 wt%, humectant 5-40 wt%, hydrophilic polymer material 4-20 wt%, cross-linking agent 0.1-3 wt%, and cross-linking regulator 0.01-2 wt%, and is prepared through common plaster preparing process. Compared with traditional preparation, the present invention contains no organic solvent, and has high safety, reduced toxic side effect and other advantages.

The invention discloses Jiawei Yupingfeng gel, a preparation method and a purpose thereof and belongs to pharmaceutical products with traditional Chinese herbal medicine. The Jiawei Yupingfeng gel is prepared through weighing milkvetch root, bighead atractylodes rhizome, Chinese parsnip root and baical skullcap root according to weight parts, and extracting and condensing to obtain extract through ethanol; adding pharmaceutic accessories (water-soluble polymer matrix-Carbopol, wetting agent-glycerol, propylene glycol, penetration enhancer-azone, pH regulating agent-triethanolamine, preservative-ethylparaben and pure water) to the extract according to the weight-to-volume ratio, and stirring uniformly. The Jiawei Yupingfeng gel is based on treating an internal illness by external treatment, and effective parts or effective ingredients in the traditional Chinese medicine raw materials are extracted to prepare into the gel according to the external transdermal absorption feature; the gel is directly used for the skin damaged by ultraviolet, and the gel does not need the first pass effect of the liver and reduces the damage of gastrointestinal tract enzyme to the gel; the gel can obviously improve the light aging skin damage; the gel has outstanding curative effect in the light aging treatment aspect.

The invention relates to the technical field of external medicines for hypertrophic scars, and particularly relates to a preparation method and an application of capsaicin-collagen sponge. The preparation method comprises the following steps: 1 preparing collagen powder from tendo calcaneus; 2 extracting the collagen powder with pepsin, so as to obtain an extract liquid; 3 centrifugally collecting supernate; 4 separating out collagen by adding sodium hydroxide, and washing, so as to prepare high-purity collagen; 5 redissolving the collagen with ethylic acid; and 6 evenly mixing the collagen liquid, glycerinum and capsaicin, and then carrying out freeze-drying, so as to obtain the capsaicin-collagen sponge. The capsaicin-collagen sponge prepared by the method is applied to tissue trauma repair and inhibition of the hypertrophic scars in the tissue trauma repair process, and has the advantage of good percutaneous permeability; the drug liver first-pass effect can be avoided; and the thrill to the skin can be reduced.

The invention provides a lornoxicam freeze-dried orally disintegrating tablet and a preparation method thereof. The lornoxicam freeze-dried orally disintegrating tablet consists of lornoxicam and a matrix, wherein the single dosage effective component lornoxicam is 4-10mg; and the matrix comprises 0.8-10mg of an adhesive, 10-200mg of a framework support agent, 0-10mg of a flavoring agent and 0-10mg of an essence. The preparation method of the lornoxicam freeze-dried orally disintegrating tablet provided by the invention comprises steps of dissolution, mold injection, quick freezing, freeze-drying and product packaging. The lornoxicam freeze-dried orally disintegrating tablet provided by the invention is simple and convenient to take and rapid to disintegrate, can be dissolved immediately after being orally taken, can be directly taken without water and is rapid to absorb, and a first pass effect can be avoided.

The invention discloses a non-steroidal anti-inflammatory drug orally disintegrating tablet and a producing method thereof, and relates to the non-steroidal anti-inflammatory drug orally disintegrating tablet and a prescription and a process utilizing the freeze-drying method to produce the non-steroidal anti-inflammatory drug orally disintegrating tablet. The non-steroidal anti-inflammatory drug orally disintegrating tablet is produced by main drug and pharmaceutic adjuvant, no water is needed while users take the tablet, and the tablet disintegrates rapidly after being delivered to the mouth, thereby the tablet is suitable for dysphagia patients such as the old, children and the like; the tablet is suitable for traveling under the condition that water is not easy to get; the non-steroidal anti-inflammatory drug orally disintegrating tablet has the advantages of convenience in taking, rapid absorption, small first pass effect, small irritation to digestive tract mucosa and the like, the tablet has a broad application prospect in the market, and the non-steroidal anti-inflammatory drug orally disintegrating tablet is capable of effectively reducing side effects of non-steroidal anti-inflammatory drugs. In addition, the invention further relates to the non-steroidal anti-inflammatory drug orally disintegrating tablet producing method.

The invention relates to a spray for treating asthma which contains active ingredients of Chinese medicinal herbs including 5-500g/L of beta-asaricin and pharmaceutically acceptable solvent. The invention has the advantages of less dosage, uniform medicament distribution, quick medicament adsorption speed, prevention of irritation to stomach and intestine, high biological availability, and ease in use.