Ribavirin inhalation powder atomizing agent and its preparing process and anti-virus infection use
A technology for inhaling powder aerosols and anti-virus, which is applied in anti-viral agents, respiratory diseases, powder delivery, etc. It can solve the problems of expanding clinical application of ribavirin and achieve the effect of reducing adverse reactions and improving curative effect
Inactive Publication Date: 2003-11-26
HONGYI SCI & TECH CO LTD NANCHANG
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AI Technical Summary
Problems solved by technology
However, due to unfavorable factors such as propellants contained in the aerosol, the listing of ribavirin inhalation aerosol has not further expanded the clinical application of ribavirin
Method used
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Experimental program
Comparison scheme
Effect test
example 3
[0074] Ribavirin 5g
[0075] Lactose 30g
[0076] Filled into 1000 capsules No. 3
[0077] The preparation method of inhaling powder mist in above-mentioned example
[0078] Take ribavirin and pulverize it in a fluidized bed supersonic airflow mill to obtain an ultrafine dry powder with a particle size of 1 μm to 5 μm and mix it with a lactose carrier with a maximum particle size of less than 200 μm obtained through high-speed grinding and pulverization. , fill No. 3 capsules, and you get it.
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The Ribavirin inhalation is a kind of respiratory tract mucous membrane absorbed preparation comprising superfine Ribavirin powder and fine medicinal carrier powder and is administrated with special administrating device. It has high and fast target effect, safe antiviral function, no stimulation to mucous membrane and other advantages. The present invention further expands the clinical application range of Ribavirin.
Description
technical field [0001] The present invention relates to a kind of medicine preparation and preparation method, specifically, it is a kind of medicine for treating virus infection, and its chemical name is 1-β-D-ribofuranosyl-1H-1,2,4-tri Azole-3-carboxamide, Molecular formula is C 8 h 12 N 4 o 5 , the molecular weight is 244.21, the general name is ribavirin powder spray and preparation method thereof. technical background [0002] Respiratory syncytial virus (RSV) is the main pathogen of respiratory tract infection in premature infants and infants under 6 months, and it is widely circulated in the northern hemisphere every winter. Almost all children have been infected by age 2. RSV infection is also prevalent in adults and the elderly and immunocompromised patients, usually mild infection but sufficient to cause bronchiolitis and pneumonia; an estimated 3 million children under 4 years of age are infected each year, of whom about 1 million Hospitalization is requir...
Claims
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IPC IPC(8): A61K9/14A61K9/48A61K9/72A61K31/7056A61P11/00A61P31/12
Inventor 许军钱进李平彭红刘智刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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