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Edaravone and (+)-2-camphol sublingual medicine composition

A technology of edaravone and its composition, applied in the field of sublingual pharmaceutical composition of edaravone and -2-borneol and its preparation, can solve the problems of discomfort, pain and stimulation of patients suffering from out-of-hospital diseases

Inactive Publication Date: 2018-03-09
YANTAI YENEPHARMA BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Some acute diseases need to be relieved quickly. Generally speaking, intramuscular or intravenous administration is the first choice for first aid, but intramuscular or intravenous injection can cause pain and irritation at the injection site, requiring medical staff to operate, and injection supplies, etc. The application is subject to certain medical restrictions, and it is not suitable for patients with out-of-hospital disease

Method used

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  • Edaravone and (+)-2-camphol sublingual medicine composition
  • Edaravone and (+)-2-camphol sublingual medicine composition
  • Edaravone and (+)-2-camphol sublingual medicine composition

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Material name

[0026] Preparation method: Mix (+)-2-camphor, edaravone, lactose, hypromellose, croscarmellose sodium and magnesium stearate evenly, and press into tablets.

Embodiment 2

[0028]

[0029]

[0030] Preparation method: Mix (+)-2-camphor, edaravone, lactose, hypromellose, croscarmellose sodium and magnesium stearate evenly, and press into tablets.

Embodiment 3

[0032] Material name

[0033] Preparation method: Mix (+)-2-camphor, edaravone, lactose, hypromellose, croscarmellose sodium and magnesium stearate evenly, and press into tablets.

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PUM

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Abstract

The invention discloses an edaravone and (+)-2-camphol composition sublingual medication preparation and a preparation method thereof, wherein the sublingual medication preparation is prepared from edaravone, (+)-2-camphol, excipients, filling agents, bonding agents, disintegrating agents, lubricating agents and the like. The sublingual medication preparation has the advantages that the first passeffect of the liver can be avoided; the sample stability is high; the transportation is convenient; the use is convenient, and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a sublingual pharmaceutical composition of edaravone and (+)-2-camphorol and a preparation method thereof. technical background [0002] Some acute diseases need to be relieved quickly. Generally speaking, intramuscular or intravenous administration is the first choice for first aid, but intramuscular or intravenous injection can cause pain and irritation at the injection site, requiring medical staff to operate, and injection supplies, etc. The application is subject to certain medical restrictions, and it is not suitable for patients with out-of-hospital disease. Sublingual preparations are directly absorbed by the sublingual mucosa, which has a large surface area and strong penetration ability, and there are a large number of capillaries in the submucosal pool to the internal jugular vein, and directly enter the blood circulation through the superior vena cava, and the drug is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/26A61K31/4152A61K31/045A61P9/10
CPCA61K9/0056A61K9/2018A61K31/045A61K31/4152A61K2300/00A61K9/006A61K9/2027A61P9/10A61K9/205A61K9/20A61K31/45A61K47/12A61K47/26A61K47/34A61K47/40A61K47/32
Inventor 王毅军
Owner YANTAI YENEPHARMA BIOMEDICAL
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