Hydrophillia Babu agent for treating depression

A technology of hydrophilic cataplasms, applied in the field of hydrophilic cataplasms, which can solve the problems of human skin irritation and poor production safety, and achieve the effects of comfortable use, safe production and good air permeability

Inactive Publication Date: 2007-07-18
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional transdermal preparations require the use of organic solvents, which are irritating to human skin and have poor production safety

Method used

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  • Hydrophillia Babu agent for treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 (making 500 tablets of cataplasm altogether)

[0030] Prescription: Fluoxetine Hydrochloride 100g

[0031] NP-600 300g

[0032] Carbomer 100g

[0033] Aluminum glycylate 6g

[0034] Citric acid 4.5g

[0035] Glycerin 550g

[0036] Azone 35g

[0037] Distilled water 2250g

[0038] Using the preparation method of cataplasm, first crush each base material to a certain fineness, weigh it precisely according to the prescription ratio, and carry out the ingredients. NP-600, aluminum glycolate, glycerin are used as a phase, citric acid, fluoxetine hydrochloride, Carbomer and distilled water are used as two phases to fully disperse, and then the two phases are quickly added to the first phase to mix evenly, coated according to a certain thickness, aged, cut, and packaged.

Embodiment 2

[0039] Embodiment 2 (making 500 tablets of cataplasm altogether)

[0040] Prescription: Fluoxetine Hydrochloride 100g

[0041] Sodium polyacrylate 250g

[0042] Methylcellulose 75g

[0043] Aluminum Chloride 3.5g

[0044] Calcium hydroxide 3.2g

[0045] Tartaric acid 5g

[0046] Glycerin 300g

[0047] Polyethylene glycol 140g

[0048] Azone 18g

[0049] Propylene glycol 80g

[0050] Distilled water 2300g

[0051] The preparation method is the same as in Example 1.

Embodiment 3

[0052] Embodiment 3 (making 500 tablets of cataplasm altogether)

[0053] Prescription: Fluoxetine Hydrochloride 100g

[0054] NP-700 250g

[0055] Aluminum citrate 8g

[0056] EDTA 2g

[0057] Gluconic Acid 3.5g

[0058] Sorbitol 450g

[0059] Nisote 40g

[0060] Distilled water 2300g

[0061] The preparation method is the same as in Example 1.

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PUM

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Abstract

A hydrophilic percutaneous medicine for treating depression is proportionally prepared from fluoxetine hydrochloride, hydrophilic high-molecular material, cross-linking agent, cross-linking regulator, humectant, percutaneous promoter, and distilled water.

Description

technical field [0001] The invention relates to a hydrophilic cataplasm, in particular to a hydrophilic cataplasm specially developed for the treatment of depression. Background technique [0002] Fluoxetine hydrochloride is a specific serotonin reuptake inhibitor, which improves depression and autonomic symptoms by selectively inhibiting the reuptake of central 5-hydroxytryptamine neurotransmitter (5-HT). It is widely used clinically in the maintenance treatment of severe depression and depression. At present, there are only oral administration methods such as solutions, common tablets, and sustained-release tablets that are clinically used. Because the maintenance treatment period for depression lasts for several years or even life, the administration of ordinary solutions and tablets is cumbersome, and the patient's medication compliance is not ideal. Although the sustained-release tablet prolongs the administration period to a certain extent, it still has general gastr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/138A61K9/70A61K47/10A61K47/14A61K47/22A61K47/32A61K47/34A61K47/38A61P25/24
Inventor 高申杨鹏丁雪鹰高静储藏郭文勇尹东锋
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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