Hydrophilic plaster for treating dysmenorrhea

Abstract

The hydrophilic plaster for treating dysmenorrheal consists of indometacin 0.15-6 wt%, salbutamol 0.01-3 wt%, transdermal promoter 0.5- 10 wt%, humectant 5-40 wt%, hydrophilic polymer material 4-20 wt%, cross-linking agent 0.1-3 wt%, and cross-linking regulator 0.01-2 wt%, and is prepared through common plaster preparing process. Compared with traditional preparation, the present invention contains no organic solvent, and has high safety, reduced toxic side effect and other advantages.

Description

technical field [0001] The invention relates to a cataplasm, in particular to a hydrophilic cataplasm specially developed for female dysmenorrhea. Background technique [0002] Indomethacin (indomethacin) is a non-steroidal anti-inflammatory analgesic drug with strong anti-inflammatory and analgesic effects. It is often used clinically for the treatment of female dysmenorrhea. Its tablets, capsules, granules, etc. are widely used in clinical , but inevitably cause gastrointestinal damage and severe adverse reactions of the central nervous system such as headache and dizziness, so that the majority of patients have to interrupt treatment. In order to reduce the toxic and side effects caused by oral absorption of indomethacin, pharmacists have tried suppository rectal administration. Although rectal administration avoids hepatic first-pass effects and gastrointestinal adverse reactions, it is inconvenient to use, and the rectal absorption of drugs is very irregular, with larg...

AI Technical Summary

Problems solved by technology

Although rectal administration avoids hepatic first-pass effect and gastrointestinal adverse reactions, it is inconvenient to use, and the rectal absorption of drugs is very irregular, with large individual differences and poor acceptability, so it is subject to certain restrictions in use.

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