Nimodipine gel for nasal cavity

Abstract

A gel of nimodipine for nasal cavity is prepared from nimodipine, hydrophilic gel and pharmacologically acceptable additive (pH regulator, humectant, anticeptic, etc). Its advantages are high biological utilization and no toxin to vibrissae.

Description

technical field [0001] The invention belongs to the field of chemical pharmacy, and in particular relates to a nasal gel of nimodipine. Background technique [0002] Nimodipine is a second-generation dihydropyridine calcium channel antagonist with the chemical name isopropyl-2-methoxyethyl-1,4-dihydro-2,6-dimethyl-4-(3- Nitrophenyl)-3,5-pyridine dibasic acid ester. It has the functions of selectively expanding cerebral blood vessels, increasing cerebral blood flow, protecting brain cells, and promoting the recovery of neuron functions. Clinically, it is mainly used to treat ischemic cerebrovascular diseases, improve the memory loss of the elderly and prevent Alzheimer's disease. There are two routes of administration of nimodipine, oral and parenteral. Injection is used for intravenous infusion and cisternal infusion. Although the onset of effect is fast and the effect is definite, it needs to be operated by professional medical personnel, and the latter still has certain...

AI Technical Summary

Problems solved by technology

Have research to adopt O / W type microemulsion to solubilize nimodipine, its maximum solubility can reach 6.4mg / ml, and there is no nose cilia toxicity, but the consumption of surfactant and co-surfactant in the microemulsion preparation is bigger (up to 30%), its potential central toxicity needs further study (Int J Pharm 2004, 275, 85-96)