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Compound orally disintegrating tablet containing loratadine and ambroxol and preparation process thereof

A technology of oral disintegrating tablets and loratadine, which is applied in the directions of pill delivery, respiratory system diseases, inactive components of polymer compounds, etc. and patent reporting

Inactive Publication Date: 2007-07-11
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Through the search, there are no relevant literature and patent reports about compound loratadine ambroxol orally disintegrating tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] prescription:

[0024]

[0025] Loratadine 5g

[0026]

[0027] Ambroxol Hydrochloride 30g

[0028] Crospovidone 55g

[0029] Mannitol 45g

[0030] Eudragit L30D 15g

[0031] Aspartame 2.5g

[0032] A total of 1000 pieces were made

[0033]

[0034] Preparation:

[0035] Add loratadine and ambroxol hydrochloride to Eudragit L30D suspension, add appropriate amount of water, stir well, then add crospovidone, mannitol, aspartame, and stir while adding to form a suspension Finally, pour it into a suitable mold, freeze it quickly, dry it under reduced pressure, take the mold, press seal it, and pack it.

Embodiment 2

[0037] prescription:

[0038]

[0039] Loratadine 10g

[0040]

[0041] Ambroxol Hydrochloride 60g

[0042] Sucrose 70g

[0043] Xanthan gum 16g

[0044] Guar Gum 24g

[0045] Xylitol 80g

[0046] Stevioside 5g

[0047] A total of 1000 pieces were made

[0048]

[0049] Preparation:

[0050] Add loratadine and ambroxol hydrochloride to the mixture of guar gum and xanthan gum, stir evenly, add sucrose, xylitol, stevioside, stir while adding to form a uniform suspension, and pour Quickly freeze in a suitable mold, dry under reduced pressure, take the mold, press seal, and pack.

Embodiment 3

[0052] prescription:

[0053]

[0054] Loratadine 5g

[0055]

[0056] Ambroxol Hydrochloride 30g

[0057] L-HPC 4g

[0058] PPVP 8g

[0059] Sorbitol 120g

[0060] Peach essence 8g

[0061]

[0062]

[0063] Magnesium Stearate 5g

[0064] A total of 1000 pieces were made

[0065]

[0066] Preparation:

[0067] Mix the loratadine, ambroxol hydrochloride, L-HPC, PPVP, and sorbitol all passed through the 80-mesh sieve evenly according to the equal volume addition method, and mix the peach flavor with the above mixture, add magnesium stearate and mix Uniform, the powder can be directly compressed into tablets.

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PUM

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Abstract

The invention relates to a luleitadingmione oral calving tablet which can treat allergic rhinitis, etc. wherein, it has quick adsorption, high biological utilization, and simple intake method without water. It uses Loratadine and bromamine acid as materials, with some findings.

Description

technical field [0001] The invention relates to a compound loratadine ambroxol orally disintegrating tablet for relieving cough with abnormal secretions and related symptoms of allergic rhinitis, such as sneezing, runny nose, nasal itching, tearing, etc., and its preparation method. Background technique [0002] Ambroxol hydrochloride is a new generation of respiratory mucus regulator, and it is also the most effective expectorant in clinical practice. It has excellent expectorant effect and can significantly promote the synthesis and secretion of alveolar surfactant. Ambroxol hydrochloride can stimulate bronchial mucus glands to secrete more flowable mucus, dilute sputum, reduce viscosity, and increase the production and secretion of pulmonary surfactant, thereby reducing airway resistance, reducing mucus adhesion, and activating Mucociliary blanket functions to facilitate mucociliary transport. Compared with the first-generation and second-generation expectorant drugs, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4545A61K9/20A61K47/10A61K47/26A61K47/36A61K47/38A61K47/40A61P11/02A61P37/08A61K31/137
Inventor 路洪书
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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