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Ginseng oral disintegration tablet and its preparing process

A technology of ginseng and disintegrant, which is applied in the field of ginseng orally disintegrating tablets, can solve undiscovered problems and achieve the effects of accurate dosage, stable quality and low production cost

Inactive Publication Date: 2005-03-02
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No orally disintegrating tablet preparations of ginseng or relevant literature have been found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment one direct flavoring method

[0034] 1. Prescription

[0035] 1. Raw materials - ginseng 320.0g;

[0036] 2. Adhesive - polyvinylpyrrolidone K-30 3.0g;

[0037] 3. Filling agent - mannitol 189.0g;

[0038] Microcrystalline cellulose 60.0g;

[0039] 4. Flavoring agent - aspartame 6.0g;

[0040] 5. Disintegrant—cross-linked polyvinylpyrrolidone 40.0g;

[0041] Croscarmellose sodium 20.0g;

[0042] 6. Glidant—micronized silica gel 6.0g;

[0043] 7. Lubricant—sodium stearyl fumarate 6.0 g.

[0044] The total weight is 650g, and a total of 1000 pieces are made.

[0045] 2. Preparation method

[0046] 1) Ginseng is crushed, granulated with polyvinylpyrrolidone K-30, water or ethanol is used as a wetting agent, passed through a 26-mesh sieve, dried, and set aside;

[0047] 2) Pass the cross-linked polyvinylpyrrolidone, cross-linked sodium carboxymethyl cellulose, micropowder silica gel, sodium stearyl fumarate and aspartame through a 40-mesh sieve, mix wel...

Embodiment 2

[0050] Example 2 Powder coating taste masking method

[0051] 1. Prescription

[0052] 1. Raw materials - ginseng 320.0g;

[0053] 2. Coating material - Eudragit  E100 64.0g;

[0054] 3. Filling agent - mannitol 163.0g;

[0055] Microcrystalline cellulose 60.0g;

[0056] 4. Flavoring agent - aspartame 6.0g;

[0057] Ginseng essence 6.0g;

[0058] 5. Disintegrant—cross-linked polyvinylpyrrolidone 40.0g;

[0059] Croscarmellose sodium 20.0g;

[0060] 6. Glidant—micronized silica gel 15.0g;

[0061] 7. Lubricant—sodium stearyl fumarate 6.0 g.

[0062] The total weight is 700g, and a total of 1000 pieces are made.

[0063] 2. Preparation method

[0064] 1) Take Eudragit  E100 is dissolved with more than 95% pharmaceutical industrial ethanol and diluted to a certain concentration for later use;

[0065] 2) Take ginseng and place it in a fluidized bed to boil, spray the above solution at a certain speed for powder coating to obtain ginseng powder coated granules, and d...

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PUM

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Abstract

The present invention relates to oral disintegrated tablet of ginseng for nourishing primordial Qi, invigorating spleen, benefiting lung, promoting the secretion of saliva and tranquilizing. Ginseng as main material as well as stuffing, disintegrating agent, corrective, flow assistant, lubricant and other supplementary material are prepared into the oral disintegrated tablet. Into the supplementary material, adhesive, coating material and / or effervescent agent may be added, if necessary. The oral disintegrated tablet of the present invention has excellent crushing degree, fast disintegration, good taste and low cost, and may be taken with no water and high curative effect.

Description

[technical field] [0001] The invention relates to a kind of medicine which has the functions of invigorating vital energy, recovering the pulse, nourishing the spleen and benefiting the lungs, promoting body fluid and calming the nerves, and can be used for body deficiency, cold extremities, slight pulse, spleen deficiency, lack of food, lung deficiency, panting and coughing, chronic illness deficiency Ginseng orally disintegrating tablet and its preparation process for diseases such as win, palpitation, insomnia, impotence and uterine cold, heart failure and cardiogenic shock. [Background technique] [0002] Ginseng (Panax ginseng C.A.Mey.) belongs to Araliaceae and belongs to the perennial dicotyledonous plant with persistent roots. The main root is fleshy, spindle-shaped or cylindrical. It is the first of the "Three Treasures of Northeast China". It is a famous and precious medicinal material at home and abroad. [0003] The reason why ginseng is very rare and expensive...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P1/14A61P9/02A61P9/04A61P11/14A61P15/08A61P25/20
Inventor 蒋海松王红喜王锦刚
Owner COSCI MED TECH CO LTD
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