Intravenous injection liquid of coenzyme Q10, and its prepn. method

Abstract

An intravenous injection of coenzyme Q10 is prepared from coenzyme Q10, solubilizer, solvent for injection,and osmotic pressure regulator through proportional mixing and sterilizing.

Description

technical field [0001] The present invention relates to coenzyme Q 10 Dosage form and preparation method thereof, especially related to coenzyme Q 10 An intravenous infusion and a preparation method thereof belong to the field of biochemical medicine. Background technique [0002] coenzyme Q 10 It is a fat-soluble quinone compound, which has the common characteristics of vitamins, and its chemical structure is similar to vitamin K. It has a variety of biological functions, especially the use of it has the advantages of small dose, low toxicity, and can assist in the treatment of various diseases. been widely applied. coenzyme Q 10 It is a good biochemical drug, which has the functions of natural anti-oxidation and cell metabolism activation, and can significantly improve human immunity. The drug is mainly used clinically for cardiovascular diseases, scurvy, aplastic anemia, duodenal ulcer , Acute and chronic viral hepatitis, subacute hepatic necrosis, congestive heart d...

AI Technical Summary

Problems solved by technology

[0003] coenzyme Q 10 It has the physical and chemical properties of being easily soluble in chloroform and benzene, easily soluble in acetone and ether, hardly soluble in ethanol, insoluble in water and methanol, and due to coenzyme Q 10 There is a quinone group in its molecular structure, which is easily decomposed when exposed to light and oxygen, making it difficult to process it into an injection for direct intravenous infusion

In the prior art, coenzyme Q 10 The dosage forms of the drug are usually tablets, capsules and injections for intramuscular injection, etc., because the tablets and capsules all have a first-pass effect after oral administration, so their bioavailability is not high. In order to solve this technical problem, the Chinese patent CN1226823 discloses " containing coenzyme Q 10 The pharmaceutical composition "provides a coenzyme Q-containing 10 A pharmaceutical composition as an active ingredient that promotes coenzyme Q after oral administration 10 Absorption; Japanese Patent JP59148718 disclosed "coenzyme Q 10 "Ingredient" In order to obtain good oral absorption and effect, it is made into microparticles by freeze-drying method for intramuscular or intravenous injection, but the existing coenzyme Q for intramuscular or intravenous injection 10 Injection, it needs to be diluted with glucose injection or other injection solvents for intravenous injection. Since it needs to be mixed according to the prescription before intravenous infusion, it is easy to be polluted by the environment and equipment during the preparation of the liquid, which leads to the use of In mild cases, nausea, fever, chills, bradycardia or tachycardia may occur, and in severe cases, it may be life-threatening. Therefore, coenzyme Q that can be directly used for intravenous infusion 10 Injection just seems extremely important in clinical application, but prior art has not yet solved the problems such as its bioavailability and stability from dosage form, has not seen coenzyme Q 10 Coenzyme Q prepared directly for intravenous infusion 10 Injections and related reports

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