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Banlangen buccal tablet and preparation method thereof

A technology of Radix Radix and its production method, which is applied in the direction of medical preparations containing active ingredients, medical formulas, and medical preparations without active ingredients, etc., which can solve the inconvenience of carrying and taking granules, the low content of active ingredients in medicines, and the disadvantages of Eliminate oral pathogens and other problems, and achieve the effects that are beneficial to quality control, prevention and treatment of viral influenza, and no liver first-pass effect

Active Publication Date: 2012-04-18
洛阳新春都生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Banlangen has the functions of preventing influenza, anti-virus, clearing away heat and detoxification, cooling blood and relieving throat, but the existing dosage forms are mostly granules, tablets, oral liquid, etc., and granules are inconvenient to carry and take. The local residence time of the pharynx and throat is short, which is not conducive to the elimination of pathogens in the oral cavity and pharynx, and it is difficult to relieve local inflammation, and the curative effect is not obvious
[0003] The patent document with the announcement number CN1233399C and the patent number 200310119261.7 discloses a effervescent tablet of Radix isatidis and its preparation method. The method adopts microwave extraction and alcohol precipitation to obtain the effective part of Radix Radix Radix, uses ethylene glycol to wrap the carbon dioxide source, and requires microwave Extraction, the process is more complicated, and the content of active ingredients in the prepared medicine is not high, which needs to be improved

Method used

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  • Banlangen buccal tablet and preparation method thereof
  • Banlangen buccal tablet and preparation method thereof
  • Banlangen buccal tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1: See Table 1 below for raw materials of Radix isatidis buccal tablets, expressed in parts by weight.

[0059] Preparation method: Weigh Radix Radix, add water to decoct twice, add 8 times the amount of water to decoct for 2.5 hours for the first time, add 6 times the amount of water to decoct for 1.5 hours for the second time, combine the two decoction liquids, and filter , the filtrate was concentrated to a density of 1.15g / cm 3 , add ethanol to make the ethanol mass content reach 55%, let it stand for precipitation, take the supernatant to recover ethanol, concentrate to a density of 1.30g / cm 3 19 parts of clear ointment; add remaining raw material medicine in described clear ointment, mix uniformly, dry, pulverize, cross 90 mesh sieves, add ethanol to granulate, the weight ratio of the amount of adding ethanol and the drug amount after sieving is 8% Then perform secondary drying at a drying temperature of 50° C. until the moisture content is below 5%, and ...

Embodiment 2

[0060] Example 2: See Table 1 for the composition of Radix Radix Radix buccal tablet.

[0061] Preparation method: Weigh Banlangen, add water to decoct twice, first add 7 times the amount of water to decoct for 2 hours, second time add 5 times the amount of water to decoct for 1 hour, combine the two decoctions, filter, and filtrate Concentrate to a density of 1.05g / cm 3 , add ethanol to make the ethanol mass content reach 50%, let it stand for precipitation, take the supernatant to recover ethanol, concentrate to a density of 1.30g / cm 3 17 parts of clear ointment; Add all the other raw materials in the clear ointment, mix uniformly, dry, pulverize, cross 80-100 mesh sieve, add ethanol to granulate, the weight ratio of the amount of adding ethanol and the drug amount after sieving is 6%; then carry out secondary drying, drying temperature is 60 ℃, to moisture mass content 1.5%, tabletting, the weight of each tablet and the amount of containing raw materials are the same as Ex...

Embodiment 3

[0062] Example 3: See Table 1 for the components of Radix isatidis buccal tablets.

[0063] Preparation method: Weigh Banlangen, add water to decoct twice, add 9 times the amount of water for the first time and decoct for 3 hours, add 7 times the amount of water for the second time and decoct for 2 hours, combine the two decoctions, filter, and filtrate Concentrate to a density of 1.25g / cm 3 , add ethanol to make the ethanol mass content reach 60%, let it stand for precipitation, take the supernatant to recover ethanol, concentrate to a density of 1.33g / cm 3 21 parts of clear ointment; Add all the other raw materials in the clear ointment, mix uniformly, dry, pulverize, cross 80-100 mesh sieve, add ethanol to granulate, the weight ratio of the amount of adding ethanol and the drug amount after sieving is 12%; then carry out secondary drying, the drying temperature is 60 ℃, to the moisture content of 1.5%, tabletting, the weight of each tablet and the amount of raw material me...

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Abstract

The invention relates to a Banlangen buccal tablet and a preparation method thereof. The Banlangen buccal tablet contains the following components: 80-120 parts of Banlangen, 10-45 parts of flavouring agent, 0.1-1 part of lubricating agent and 120-170 parts of golden buckwheat rhizome. The preparation method comprises the following steps of: during production, weighing the banlangen firstly, decocting twice by adding water, merging decoction, filtering, concentrating the filtrate until the density is 1.05-1.25g / cm<3>, adding ethanol to ensure that the content of the ethanol reaches 50-60 percent, standing, taking supernate, recycling the ethanol and concentrating to form an extract with the density of 1.30-1.33g / cm<3>; adding the flavouring agent and the lubricating agent, uniformly mixing, drying, crushing, adding ethanol granulations, drying for the second time until the water content ranges from 1.5 to 5 percent, and finally tabletting. The buccal tablet can be used for preventing and treating viral influenza, reaches the cure rate of 64.6 percent when used for treating acpuei pharyngitis, chronic pharyngitis, acute tonsillitis and other diseases, achieves the total effective rate of 97.6 percent, has good durative effect which is obviously better than that of like products, is convenient to take and is suitable for various crowds.

Description

1. Technical field: [0001] The invention relates to a traditional Chinese medicine composition, in particular to a Radix isatidis buccal tablet and a preparation method thereof. 2. Background technology: [0002] Banlangen has the functions of preventing influenza, anti-virus, clearing away heat and detoxification, cooling blood and relieving throat, but the existing dosage forms are mostly granules, tablets, oral liquid, etc., and granules are inconvenient to carry and take. The local residence time of pharynx and throat is short, which is not conducive to the elimination of pathogens in the oral cavity and pharynx, and it is difficult to relieve local inflammation, and the curative effect is not obvious. [0003] The patent document with the announcement number CN1233399C and the patent number 200310119261.7 discloses a effervescent tablet of Radix isatidis and its preparation method. The method adopts microwave extraction and alcohol precipitation to obtain the effective ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/19A61K36/315A61K36/70A61K9/20A61K47/46A61P11/04A61P31/14A61P31/16
Inventor 柴战欣关润红辛俊苗卫丽军常虹王娓娓
Owner 洛阳新春都生物制药有限公司
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