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Sumatriptan pharmaceutical composition used in nasal cavity and preparation method thereof

A composition and drug technology, applied in the field of new formulations of sumatriptan, can solve problems such as inconvenient use of injections, easy to cause gastrointestinal adverse reactions, pain, etc.

Inactive Publication Date: 2012-07-04
HUNAN JIUDIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are ordinary oral preparations and injections of sumatriptan on the market, because the injections are inconvenient to use and cause pain when used locally, while the oral preparations have a first-pass effect, which can easily cause gastrointestinal adverse reactions when taken

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Raw materials g

[0023] Sumatriptan succinate 700 (equivalent to sumatriptan 500)

[0024] Sodium chloride 21.0

[0025] Methylparaben 5.0

[0026] Ethylparaben 5.0

[0027] Weigh the raw and auxiliary materials according to the prescription amount. First mix the excipients methylparaben and ethylparaben, then add about 8000ml of water, heat to 40°C, stir and dissolve, then add the weighed sumatriptan succinate and sodium chloride , stir and make it dissolve, cool to room temperature, add water to 10000ml, filter with a microporous membrane, pack in 10ml plastic bottles with quantitative valve caps, and prepare 1000 bottles of the medicine of the present invention.

Embodiment 2

[0036] Raw materials g

[0037] Sumatriptan 1000

[0038] Sodium chloride 25.0

[0039] Methylparaben 7.0

[0040] Ethylparaben 7.0

[0041] Weigh the raw and auxiliary materials according to the prescription amount; first mix the auxiliary materials methylparaben and ethylparaben, then add about 7500ml of water, heat to 45°C and stir to dissolve, then add the weighed succinic acid Sumatriptan and sodium chloride are stirred and dissolved, cooled to room temperature, added with water to 10000ml, filtered with a microporous membrane, and packed in 10ml plastic bottles with quantitative valve caps to prepare the medicine of the present invention 1000 bottles.

Embodiment 3

[0043] Raw materials g

[0044] Sumatriptan 500

[0045] Sodium chloride 18.0

[0046] Methylparaben 20.0

[0047] Ethylparaben 20.0

[0048] Weigh the raw and auxiliary materials according to the prescription amount; first mix the auxiliary materials methylparaben and ethylparaben, then add about 8500ml of water, heat to 50°C and stir to dissolve, then add the weighed succinic acid Sumatriptan and sodium chloride are stirred and dissolved, cooled to room temperature, added with water to 10000ml, filtered with a microporous membrane, and packed in 10ml plastic bottles with quantitative valve caps to prepare the medicine of the present invention 1000 bottles.

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PUM

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Abstract

The invention provides a sumatriptan pharmaceutical composition used in the nasal cavity, which comprises sumatriptan and corresponding excipients. The sumatriptan pharmaceutical composition disclosed by the invention has the advantages of simple formula, low cost, great efficacy for treating migraine and effects of saving cost and improving the efficacy.

Description

field of invention [0001] The invention belongs to the field of chemical medicine invention, and relates to a pharmaceutical composition whose main component is sumatriptan, in particular to a new dosage form of sumatriptan used in nasal cavity. Background technique [0002] Migraine is one of the common diseases in neurology. With the acceleration of modern life rhythm, its incidence is on the rise. The headache is severe and recurrent, and severe cases are accompanied by nausea and vomiting. The incidence rate is generally above 5%, and most patients are women. There has been no ideal treatment for migraine, and analgesics and ergotamines are mainly used for treatment, while ergotamine, caffeine, etc. cause nausea and vomiting in some patients during treatment, and the curative effects are not ideal. , Learning and life have a greater impact. [0003] Because migraine is a recurring and even lifelong disease, drug therapy must be highly effective and tolerable over the l...

Claims

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Application Information

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IPC IPC(8): A61K31/4045A61K47/14A61P25/06
Inventor 朱志宏卜振军杨静
Owner HUNAN JIUDIAN PHARMA
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