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Nimesulide injection for livestock and preparation method thereof

A nimesulide and injection technology, applied in the field of injections, can solve the problems of slow onset of action and achieve rapid onset of action, high bioavailability, and broad market prospects

Active Publication Date: 2011-07-13
泰州骏道立同生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the content of nimesulide in the composition reaches 25-100 mg / mL, the excipient base used is oily base and organic solvent, and the excipient base accounts for 90%-97.5% of the total composition , causing nimesulide to not be released and absorbed quickly in muscle tissue, and the onset of action is slow

Method used

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  • Nimesulide injection for livestock and preparation method thereof
  • Nimesulide injection for livestock and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Prescription: 2g of nimesulide, 2mL of ethanolamine, 0.2g of sodium sulfite, 0.01g of disodium edetate, appropriate amount of lactic acid, and add water for injection to 100mL.

[0018] Preparation method: includes the following steps:

[0019] a. Dosing: take 20mL of water for injection, add 2mL of ethanolamine, stir and mix at a slow speed, then add 2g of nimesulide, and stir until completely dissolved to obtain solution A; take another 20mL of water for injection, add 0.2g of sodium sulfite and ethylene disulfide Disodium amine tetraacetate 0.01g, stirred until completely dissolved to obtain solution B; slowly add solution A to solution B under slow stirring (no vortex to reduce contact with air), add water for injection to 90mL, and use lactic acid Adjust the pH to 7.5, and then dilute to 100mL with water for injection to obtain solution C;

[0020] b. Filtration and sterilization: filter solution C successively with microporous membranes with a pore size of 0.45 μ...

Embodiment 2

[0023] Prescription: 4g of nimesulide, 4mL of ethanolamine, 0.3g of sodium sulfite, 0.01g of disodium edetate, appropriate amount of lactic acid, and add water for injection to 100mL.

[0024] Preparation method: includes the following steps:

[0025] a. Dosing: take 20mL of water for injection, add 4mL of ethanolamine, stir and mix at a slow speed, then add 4g of nimesulide, stir until completely dissolved to obtain solution A; take another 20mL of water for injection, add 0.23g of sodium sulfite and Disodium amine tetraacetate 0.01g, stirred until completely dissolved to obtain solution B; slowly add solution A to solution B under slow stirring (no vortex to reduce contact with air), add water for injection to 90mL, and use lactic acid Adjust the pH to 7.5, and then dilute to 100mL with water for injection to obtain solution C;

[0026] b. Filtration and sterilization: filter solution C successively with microporous membranes with a pore size of 0.45 μm and 0.22 μm, fill th...

Embodiment 3

[0029] Prescription: 6g of nimesulide, 6mL of ethanolamine, 0.3g of sodium sulfite, 0.015g of disodium edetate, appropriate amount of lactic acid, and add water for injection to 100mL.

[0030] Preparation method: includes the following steps:

[0031] a. Dosing: take 20mL of water for injection, add 6mL of ethanolamine, stir and mix at a slow speed, then add 6g of nimesulide, and stir until completely dissolved to obtain solution A; take another 20mL of water for injection, add 0.3g of sodium sulfite and ethylene disulfide Disodium amine tetraacetate 0.015g, stirred until completely dissolved to obtain solution B; slowly add solution A to solution B under slow stirring (no vortex to reduce contact with air), add water for injection to 90mL, and use lactic acid Adjust the pH to 8.0, then dilute to 100mL with water for injection to obtain solution C;

[0032] b. Filtration and sterilization: filter solution C successively with microporous membranes with a pore size of 0.45 μm ...

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Abstract

The invention discloses a Nimesulide injection for livestock and a preparation method thereof. Each 100mL of injection comprises the following components: 2-10g of Nimesulide, 2-10mL of ethanolamine, 0.2-0.4g of sodium sulfite, 0.01-0.02g of disodium ethylene diamine tetraacetate and balance of water for injection, wherein the pH value is regulated to 7-9 with lactic acid. The preparation method of the Nimesulide injection for livestock mainly comprises the steps of liquid preparing, filtering, sterilizing and the like. The injection can be used through intramuscular, subcutaneous or intravenous administration, has obvious effect, no first pass effect of the liver, high bioavailability, simple preparation processes, stable, safe and effective products and low cost, is suitable for industrial mass production, and has wide market prospects.

Description

technical field [0001] The invention relates to an injection, in particular to a nimesulide injection for veterinary use, and also relates to a preparation method of the injection. Background technique [0002] Nimesulide, whose chemical name is 4-nitro-2-phenoxymethanesulfonanilide, is easily soluble in acetone, slightly soluble in ethanol, and almost insoluble in water. Nimesulide has antipyretic, analgesic, anti-inflammatory, anti-rheumatic effects, and is mainly used for fever symptoms caused by upper respiratory tract infection, pain after surgery and acute trauma, and pain caused by inflammation of the ear, nasopharynx, etc. , Dysmenorrhea, rheumatoid arthritis and osteoarthritis, etc.; in veterinary clinics, it is mainly used for common cold, influenza, fever caused by bacteria, viruses or protozoa, dull pain, rheumatism, etc. [0003] At present, the nimesulide preparations sold in the market are mainly oral preparations such as tablets, capsules, and granules, and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/18A61K47/18A61P29/00A61P31/04A61P31/12A61P31/16A61P33/02
Inventor 罗永煌陈君雷曙光罗雷田朋鑫刘艳玲聂延君乔彦茹
Owner 泰州骏道立同生物科技有限公司
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