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Curcumin powder mist inhalation preparation and preparation method thereof

A technology of inhalation preparation and curcumin, applied in the field of medicine, can solve problems such as no report on research on curcumin powder mist inhalation preparation, etc., and achieve the effects of improving bioavailability, reducing systemic effects, and reducing absorption into blood

Active Publication Date: 2020-10-13
天津市医药科学研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But, the research about curcumin powder mist inhalation preparation has not been reported at present

Method used

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  • Curcumin powder mist inhalation preparation and preparation method thereof
  • Curcumin powder mist inhalation preparation and preparation method thereof
  • Curcumin powder mist inhalation preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Curcumin powder mist inhalation preparations include the following raw materials: curcumin 1g, glyceryl monostearate 10g, PEG-25 stearate 20g, poloxamer 18810g, Tween-8020g, trehalose 40g, 400 inhalation of lactose 70g and water 2000g.

[0052] The preparation method specifically comprises the following steps:

[0053] (1) take each raw material by the weight of above-mentioned curcumin powder mist inhalation preparation;

[0054] (2) Curcumin, glyceryl monostearate and PEG-25 stearate are added in 500g of absolute ethanol, placed on a constant temperature magnetic stirrer, at a temperature of 78 ° C and a speed of 900 rpm. Stir for 2 minutes until dissolved to obtain an organic phase, which is set aside;

[0055] (3) Poloxamer 188 and Tween-80 were added to water, placed on a constant temperature magnetic stirrer, and stirred at a temperature of 75°C and a speed of 900 rpm for 5 minutes until dissolved to obtain an aqueous phase;

[0056] (4) Slowly add the organic...

Embodiment 2

[0061] Curcumin powder mist inhalation preparations include the following raw materials: curcumin 1g, glyceryl behenate 9g, PEG-36 stearate 19g, poloxamer 1889g, Tween-8019g, trehalose 36g, 40064g and 1800g of water.

[0062] The preparation method specifically comprises the following steps:

[0063] (1) take each raw material by the weight of above-mentioned curcumin powder mist inhalation preparation;

[0064] (2) Add curcumin, glyceryl behenate and PEG-36 stearate into 440g of absolute ethanol, place it on a constant temperature magnetic stirrer, and stir it under constant temperature magnetic force at a temperature of 75°C and a speed of 420rpm 1min until dissolved, the organic phase was obtained and set aside;

[0065] (3) Poloxamer 188 and Tween-80 were added to water, placed on a constant temperature magnetic stirrer, and stirred at a temperature of 70°C and a speed of 420 rpm for 3 minutes until dissolved to obtain an aqueous phase;

[0066] (4) Slowly add the orga...

Embodiment 3

[0071] Curcumin powder mist inhalation preparations include the following raw materials: curcumin 1.25g, glyceryl distearate 11g, PEG-40 stearate 22g, poloxamer 18811g, Tween-8022g, mannitol 44g , 40079g and 2200g of water.

[0072] The preparation method specifically comprises the following steps:

[0073] (1) take each raw material by the weight of above-mentioned curcumin powder mist inhalation preparation;

[0074] (2) Curcumin, glyceryl distearate and PEG-40 stearate are added in 610g of absolute ethanol, placed on a constant temperature magnetic stirrer, at a temperature of 80°C and a speed of 900rpm. Stir for 3 minutes until dissolved to obtain an organic phase, which is set aside;

[0075] (3) Poloxamer 188 and Tween-80 were added to water, placed on a constant temperature magnetic stirrer, and stirred at a temperature of 78°C and a speed of 900 rpm for 5 minutes until dissolved to obtain an aqueous phase;

[0076] (4) Slowly add the organic phase to the water pha...

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Abstract

The present invention discloses a curcumin powder mist inhalation preparation. The curcumin powder mist inhalation preparation comprises the following raw materials: curcumin, a lipid material, polyoxyethylene stearate, poloxamer 188, Tween-80, a freeze-drying protective agent, lactose and water. A preparation method is as follows: (1) respectively weighing the raw materials; (2) adding the curcumin, lipid material and polyoxyethylene stearate into absolute ethanol to dissolve to obtain an organic phase; (3) adding the poloxamer 188 and Tween-80 into water to be dissolved to obtain a water phase; (4) adding the organic phase to the water phase to remove the absolute ethanol; (5) adding into cold water, keeping stirring in a cold water bath and conducting filtering; (6) adding the freeze-drying protective agent to conduct freeze-drying; and (7) adding the lactose and conducting sieving to obtain a finished product. Propellants and solvents are not used, airflow is relied to enable medicinal powder to be atomized, thus the medicinal powder is transferred to the lungs, and the curcumin powder mist inhalation preparation has characteristics of convenient application, rapid absorption and targeted positioning.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a powder mist inhalation preparation, more specifically to a curcumin powder mist inhalation preparation and a preparation method thereof. Background technique [0002] Curcumin is a chemical component extracted from the rhizomes of some plants in Zingiberaceae and Araceae. Among them, turmeric contains about 3%-6%. It is a rare pigment with diketones in the plant kingdom, which is diketones compound. Its main bioactive components are curcuminoids and volatile oils. The former has the effects of lowering blood fat, anticoagulation, anti-oxidation, choleretic, and anti-cancer, and the latter mainly has anti-inflammatory, antibacterial, and antitussive effects. Curcumin exerts its anti-cancer effect by inducing the differentiation of malignant tumor cells, inducing tumor cell apoptosis and inhibiting the various stages of tumor growth. (COPD) and asthma, etc. have significant th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K9/14A61K47/14A61K47/12A61K47/26A61K47/36A61K47/10A61K31/12A61P11/00
CPCA61K9/0075A61K9/145A61K9/146A61K31/12A61P11/00
Inventor 李楠李旭
Owner 天津市医药科学研究所
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