Stable ambroxol theophylline acetate solution for inhalation

A technology of ambroxol acetate and theophylline acetic acid, which is applied in the field of chemical medicine, can solve the problems of poor stability of theophylline ambroxol acetate, serious decomposition of active ingredients, and failure to meet sustainable development, so as to avoid treatment time and cost Fast-acting, fast-acting effect

Inactive Publication Date: 2017-05-31
SHIJIAZHUANG UNIVERSITY
View PDF5 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of preparation in the prior art uses chemical solvents, which directly leads to high production costs, and the use of a large amount of ethyl acetate and dimethylformamide leads to environmental pollution, which does not conform to the concept of sustainable development
Simultaneously, the theophylline ambroxol acetate prepared by the prior art has a poor stabilizing effect, is easily decomposed, has a short storage time, and the active ingredient decomposes seriously, and the use effect is greatly reduced

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Stable ambroxol theophylline acetate solution for inhalation
  • Stable ambroxol theophylline acetate solution for inhalation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A stable theophylline acetate ambroxol solution for inhalation, comprising theophylline acetate, ambroxol hydrochloride, surfactants, antioxidants and preservatives; Broxol 0.1g, the quality of surfactant is 3% of theophylline acetic acid, the quality of antioxidant is 0.03% of theophylline acetic acid, the amount of preservative added is 0, and the pH of the detection solution is 2.1.

[0023] The surfactant is lecithin and soybean lecithin, and the antioxidant is citric acid.

Embodiment 2

[0025] A stable theophylline acetate ambroxol solution for inhalation comprises theophylline acetate, ambroxol hydrochloride, surfactants, antioxidants and preservatives; Broxol 0.2g, surfactant quality is 4% of theophylline acetic acid, antioxidant quality is 0.02% of theophylline acetic acid, preservative addition is 0.01%, and the pH of the solution is 3.2.

[0026] The surfactant is polyethylene glycol, the antioxidant is lactic acid and sodium sulfite, and the preservative is benzoic acid.

Embodiment 3

[0028] A stable theophylline acetate ambroxol solution for inhalation, comprising theophylline acetate, ambroxol hydrochloride, surfactant, antioxidant and preservative; and containing theophylline acetate in every 100ml isotonic glucose solution is 0.1g, Ambroxol hydrochloride 0.3g, surfactant quality are 5% of theophylline acetic acid, antioxidant quality is 0.01% of theophylline acetic acid, the addition of antiseptic is 0, and the pH of solution is 4.1.

[0029] The surfactant is oleic acid alcohol, and the antioxidant is sodium sulfite.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a stable ambroxol theophylline acetate solution for inhalation and belongs to the field of chemical pharmaceuticals. The stable ambroxol theophylline acetate solution comprises theophylline acetic acid, ambroxol hydrochloride, a surfactant, an antioxidant, and a preservative. Furthermore, 100 ml of solvent contains 0.1-0.3 g of theophylline acetic acid, 0.1-0.3 g of ambroxol hydrochloride, and the surfactant accounting for 3-6% of the theophylline acetic acid by weight, and pH of the solution is 2.0-5.8. The stable ambroxol theophylline acetate solution for inhalation in the invention is good in stability and long in storage time. This solution may have no significant change in active ingredients after being stored at room temperature for one year.

Description

technical field [0001] The invention belongs to the field of chemical medicine and relates to a theophylline ambroxol acetate solution, in particular to a stable theophylline ambroxol acetate solution for inhalation. Background technique [0002] As we all know, theophylline ambroxol acetate, also known as theophylline acetate bromide, is theophylline derivatives, molecular formula: C 22 h 28 Br 2 N 6 o 5 , is a double salt formed by equimolar ambroxol and theophylline acetic acid, so it has the pharmacological and clinical effects of both ambroxol and theophylline acetic acid, and is a kind of product that promotes expectoration, improves respiratory conditions, and has obvious anti-inflammatory effects. Novel drug with anti-inflammatory ability; the existing theophylline ambroxol acetate has poor stabilizing effect and short storage time. [0003] The prior art mostly uses dimethylformamide as a solvent, theophylline acetic acid and ambroxol base react in this solvent...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K9/72A61K47/24A61K47/10A61K47/12A61K47/32A61K47/26A61P11/14A61P11/10A61K31/137
CPCA61K9/007A61K9/0073A61K9/08A61K31/137A61K31/522A61K47/10A61K47/12A61K47/24A61K47/26A61K47/32A61K2300/00
Inventor 周冉常明郧海丽王飞胡瑞省于宏伟
Owner SHIJIAZHUANG UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap