The invention provides an air vibratory sputum excretion machine, belonging to the technical field of medical apparatus and instruments. The machine comprises a shell, an air chamber, a first tympanic membrane tray, a second tympanic membrane tray, a power machine, an air induction mechanism, a tympanic membrane actuating mechanism, a breather pipe and a wearing device, wherein the shell is provided with a rack; the air chamber is defined by a first side plate, a second side plate, a third side plate, a fourth side plate, a top plate and a bottom plate, and provided with an air cavity; the first side plate is provided with a first tympanic membrane tray cavity; the second side plate is provided with a second tympanic membrane tray cavity; a first tympanic membrane tray is arranged on the first tympanic membrane tray cavity; a second tympanic membrane tray is arranged on the second tympanic membrane tray cavity; the power machine is fixed on the bottom plate or the rack; a power shaft of the power machine is stretched into the air cavity by the bottom plate; the air induction mechanism is fixed on the rack and communicated with the air cavity; the tympanic membrane actuating mechanism is arranged in the air cavity and connected with the power shaft as well as the first and second tympanic membrane trays; the wearing device is to be worn by a patient; and one end of the breather pipe is communicated with the air cavity, and the other end of the breather pipe is connected with the wearing device. The air vibratory sputum excretion machine is applicable to any occasion, has simple overall structure, can relieve labor intensity of therapists, has good effect in patting chests and backs of the patients, and is beneficial to excreting sputum.