The invention discloses health maintenance wine and a preparation method thereof. The health maintenance wine is prepared from the following raw materials in parts by weight: 250-280 parts of grapes, 25-35 parts of chickpeas, 20-30 parts of honeylocus seeds, 15-20 parts of pumpkin flowers, 30-40 parts of hawthorn fruits, 4-6 parts of rhizoma polygonati, 2-4 parts of mango stones, 2-3 parts of flores aurantii, 2-3 parts of rehmannia flowers, 1-2 parts of the root of red-rooted salvia, 1-2 parts of silverweed cinquefoil root, 2-3 parts of eucommia male flowers, 2-3 parts of flower buds of panax notoginseng, 58-65 parts of black tea juice, 20-40 parts of grape pulp, 6-9 parts of yeasts and 8-10 parts of nutrition additives. The health maintenance wine disclosed by the invention is pure, mellow and sweet in taste, is added with the nutritional ingredients such as the hawthorn fruits, pumpkin flowers and black tea juice, has the effects of regulating the taste, promoting the gastrointestinal metabolic functions and eliminating fatigue and is beneficial to human health. Meanwhile, multiple traditional Chinese medicine beneficial components are added into the wine, and the wine has the effects of clearing away heart-fire, relieving restlessness, calming heart, soothing nerves, strengthening spleen, promoting appetite, maintaining health, resisting senility and the like and is health maintenance wine capable of being eaten with rice for patients suffering from multiple diseases such as long-standing weakness, poor appetite, dyspepsia and hypoimmunity.