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Curcumin compound dry powder inhaler as well as preparation method and application thereof

A dry powder inhaler and dry powder inhaler technology, applied in the field of medicine, can solve the problems of allergic reactions, unreported research, etc., and achieve the effects of high drug concentration, good fluidity, and good lung deposition.

Inactive Publication Date: 2011-06-01
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the research of dry powder inhalation of curcuminoids
[0004] In addition, the currently marketed dry powder inhalers generally use lactose as the excipient carrier. However, the impurities in lactose may cause severe allergic reactions. Therefore, it is urgent to develop dry powder inhalation preparations without lactose carriers.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The curcumin was jet milled to D 90 = 3.5 µm, with D 50 The lactose of =130 microns is mixed at a mass ratio of 1:8, and after mixing evenly, the powder is packed into capsules or blisters or dry powder inhalers to obtain dry powder inhalers.

Embodiment 2

[0027] Mix demethoxycurcumin and micropowder silica gel at a mass ratio of 1:1, and use jet milling to D 90 = 4.8 microns, the powder is packed into capsules or blisters or dry powder inhalers to obtain dry powder inhalers.

Embodiment 3

[0029] Dedimethoxy curcumin was jet milled to D 90 = 4.1 µm, with D 90 = 4.6 microns of lactose, D 50 The lactose of =150 microns is mixed at a mass ratio of 1:1:8, and after mixing evenly, the powder is packed into capsules or blisters or dry powder inhalers to obtain dry powder inhalers.

[0030] Study on Pulmonary Deposition Rate of Dry Powder Inhalation

[0031] According to the method specified in the Pharmacopoeia of the People's Republic of China in 2010, the lung deposition rate of the preparation reached 27.16%. After being placed at room temperature for 24 months, the lung deposition rate of the preparation did not change significantly.

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PUM

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Abstract

The invention relates to a curcumin compound dry powder inhaler as well as a preparation method and application thereof. The curcumin compound dry powder inhaler is a medicinal composition prepared by mixing a curcumin compound as an active constituent, and pharmaceutically acceptable auxiliary materials. Compared with orally drug administration, the effect of the curcumin compound dry powder inhaler developed according to the technical scheme provided by the invention on treating pulmonary fibrosis and lung tumors is greatly improved.

Description

technical field [0001] The invention relates to a curcuminoid compound dry powder inhaler, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] In recent years, the research work of curcuminoids has attracted much attention at home and abroad, mainly including curcumin, demethoxycurcumin, demethoxycurcumin, dihydrocurcumin, tetrahydrocurcumin and other curcuminoids. prime derivatives. Curcumin compounds have shown good therapeutic value and application prospects in the prevention and treatment of lung diseases such as pulmonary fibrosis and lung cancer. However, due to the poor oral absorption and low bioavailability of curcuminoids, curcuminoids have limited the efficacy of curcuminoids, so far there is still no curcuminoid preparations on the market. [0003] Inhalants administered through the mouth have many advantages: drugs can quickly settle in the lungs after inhalation, can avoid or reduce toxic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K9/14A61K9/48A61K31/12A61K47/18A61P11/00A61P35/00
Inventor 吕慧侠张振海周建平
Owner CHINA PHARM UNIV
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