32 results about "Lung deposition" patented technology

The invention discloses an alkaline phosphatase micro- / nano-particle which comprises alkaline phosphatase as drug and adjuvants at weight ratio of 1:100-100:1. The adjuvants comprise stabilizer and dispersant at weight ratio of 1:100-100:1. The micro- / nano-particle has yield of 20-98%, average particle size of 0.1-10 micrometer, bio-active drug activity retention rate of 50-100%, and in-vitro lung deposition efficiency of 10-98%. The micro- / nano-particle with small and uniform particle size and good dispersivity can be delivered into lung in multiple lung inhalation preparation forms, can effectively maintain drug bioactivity, and has excellent lung inhalation efficiency, no gastrointestinal tract degradation effect and no liver first pass effect during application course, and good patient compliance due to non-invasive treatment manner.

The invention discloses an oral lung inhalation aerosol powder, which can improve the lung deposition rate of active ingredients of the aerosol powder, avoid the deposition of carrier micropowder in the lung, and increase the stability of the composition. The oral lung inhalation aerosol powder consists of the active ingredients and the carrier micropowder. The oral lung inhalation aerosol powderis characterized in that: the mean grain size of the micropowder of the active ingredients is between 0.5 and 10 mu m, and the mean grain size of the carrier micropowder is between 20 and 45 mu m.

The present invention relates to CO 2 The preparation method and application of the responsive micro-nano drug delivery system can effectively solve the problems of lung deposition ability, reduce the systemic distribution of drugs, reduce systemic toxic and side effects, perform responsive slow release in the lungs, and improve drug utilization and curative effect. The method Yes, to prepare polylactic acid-polylysine polymer, dissolve polylactic acid-polylysine polymer with dimethyl sulfoxide, then add N,N dimethylacetamide dimethyl acetal, react under nitrogen protection, and dialyze , freeze-dried, dissolved in dimethyl sulfoxide with budesonide, added ultrapure water, dialyzed, and freeze-dried to obtain PLA-mPLL / BUD nanoparticles; to prepare yeast microcapsules, dissolve PLA-mPLL / BUD nanoparticles in Add yeast microcapsules to ultrapure water, vortex to mix, incubate at room temperature, centrifuge, freeze-dry to obtain CO 2 Responsive micro-nano drug delivery system YGM / PLA‑mPLL / BUD. The preparation method of the invention is simple, the raw materials are abundant, and the production and preparation are easy, and it is a great innovation in medicines for treating asthma, pulmonary fibrosis, chronic obstructive pulmonary disease, pneumonia and lung injury.

The invention discloses a preparing method of medicine-additive mode composite micro powder. The composite micro powder is structurally characterized in that medicine particles with the geometric particle size of 1-10 microns are located in the centers, additive modified gas-phase white carbon black with the geometric particle size of 10-65 nm are adsorbed to the surfaces of the medicine particles, and the aerodynamics particle size of particles of the composite micro powder is smaller than 10 microns. The preparing method with pentoxyverine as representative medicine includes the following steps that a modifying agent for the modified gas-phase white carbon black is prepared from one or more of hexamethyldisilazane, cyclo-silazane and octyltriethoxysilane, and the geometric particle size of the modified gas-phase white carbon black is 10-65 nm; pentoxyverine turbid liquid is prepared, wherein the geometric particle size of turbid particles is 1-10 microns; the modified gas-phase white carbon black is added into the turbid liquid, wherein the mass percent of the additive to the medicine is 10-70%:30-90%; the mixed turbid liquid is subjected to spray drying, and the composite micro powder is obtained. The preparing method is simple in technology, low in cost and short in period. Compared with carrier-free-mode micro powder, the composite micro powder has the more excellent aerodynamics performance, the more excellent lung deposition performance, the more excellent fluidity and the more excellent dispersion degree.

The invention of the present application relates to an apparatus to aid in administering inhaled pharmaceutical aerosol to a patient. The apparatus is used in conjunction with an aerosol delivery device. The apparatus comprises steps on the top and bottom of the apparatus, which when used aid the patient causes mandibular advancement, and opening of the mouth, causing opening of patient's airway, resulting in improved aerosol lung deposition. The invention also relates to a method of using such apparatus in a combination with an aerosol delivery device or a system, and to the mouthpiece of said apparatus.