Asarone dry powder inhalant and method for preparing same

A technology of brain-dry powder and inhalant, which is applied in the field of medicine, can solve the problems of inability to be directly freeze-dried, the safety impact of inhalation preparations, and the inability to evaporate solvents, etc., and achieve the effects of fast onset, easy portability, and high stability

Inactive Publication Date: 2012-08-01
广州万泽医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The melting point of asarone is only about 60°C, so it is not suitable for spray drying, because the melting point is too low, the

Method used

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  • Asarone dry powder inhalant and method for preparing same
  • Asarone dry powder inhalant and method for preparing same
  • Asarone dry powder inhalant and method for preparing same

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preparation example Construction

[0031] The preparation method of Asarum dry powder inhalation comprises the steps:

[0032] (1) After asarone is mixed with auxiliary materials, it is contacted and crushed with a high-speed airflow with a crushing pressure of 0.4 to 0.7Mpa to obtain micropowder; the auxiliary materials are one or more of magnesium stearate, lactose, and mannitol; The mass percentage of the asarone is 50% to 100%, and the mass percentage of the auxiliary material is 0% to 50%;

[0033] (2) Mix the micropowder obtained in step (1) with a medically acceptable carrier, collect it in capsules or aluminum-plastic blisters, or directly pack it into an inhalation device to obtain the product.

[0034] Asarone in the present invention is a natural extract, an artificial compound or a mixture of the two.

Embodiment 1

[0035] The preparation method of embodiment 1 Asarum dry powder inhalation

[0036] Including the following steps:

[0037] (1) after asarone and lactose (adjuvant) are mixed uniformly, be that the high-speed air flow of crushing pressure is 0.7Mpa in jet mill and pulverize, obtain micropowder; The mass percentage composition of described asarone is 50%, The mass percentage of the lactose is 50%; the micropowder yield is 21.79%; the micropowder content below 5 μm is 37.90%;

[0038] (2) Mix the micropowder obtained in step (1) with lactose (carrier) evenly, and pack them in 3# HPMC plant capsules to obtain dry asarum powder inhalation.

Embodiment 2

[0039] The preparation method of embodiment 2 Asarum dry powder inhalation

[0040] Including the following steps:

[0041] (1) After asarone and magnesium stearate (adjuvant) are mixed homogeneously, be the high-speed air flow contact pulverization of 0.4Mpa with crushing pressure in jet mill, obtain micropowder; The mass percentage composition of described asarone is: 99.5%, the mass percentage of the magnesium stearate is 0.5%; the micropowder yield is 12.42%; the micropowder content below 5 μm is 35.97%;

[0042] (2) Mix the micropowder obtained in step (1) with lactose (carrier) evenly, and pack them in 3# HPMC plant capsules to obtain dry asarum powder inhalation.

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Abstract

The invention discloses an asarone dry powder inhalant and a method for preparing the same. The method for preparing the asarone dry powder inhalant includes steps: mixing asarone with auxiliary materials, and allowing the mixture to contact with high-speed air flow with crushing pressure being 0.4-0.7Mpa to be crushed to obtain micro powder, wherein the mass percentage content of the asarone ranges from 50% to 100%, and the mass percentage content of the auxiliary materials ranges from 0% to 50%; and mixing the micro powder with a medically acceptable carrier to obtain the asarone dry powder inhalant. The asarone dry powder inhalant is a novel agent and simple in preparation process, asarone medicine can be micronized, and lung deposition rate is increased. Further, the asarone dry powder inhalant has the advantages of quickness in effect, convenience in use and carrying, high stability and the like and is clinically widely applicable to treatment of asthma, chronic obstructive pulmonary disease and the like.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an α-asarum brain stem powder inhaler and a preparation method thereof. Background technique [0002] Asthma is a worldwide disease. According to the 2007 guidelines of the Global Strategy for the Prevention and Treatment of Asthma, there are about 300 million asthmatic patients in the world. The incidence of asthma in various countries varies from 1% to 18%, and the incidence is still increasing. Every year, an estimated 250,000 people die from asthma worldwide. According to the survey, there are more than 20 million asthma patients in China, and the incidence rate of asthma in China is about 2.0%, and it is increasing year by year; the mortality rate is about 4 / 10,000, ranking first in the global mortality rate. [0003] Chronic obstructive pulmonary disease (COPD) is a disease characterized by airflow limitation that is not fully reversible. Airflow limitation is usually p...

Claims

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Application Information

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IPC IPC(8): A61K9/72A61K31/09A61P11/00
Inventor 吴传斌杜鹏阳李姝瑾潘昕
Owner 广州万泽医药科技有限公司
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